2 research outputs found
Sintesis, uji aktivitas analgesik dan anti- inflamasi senyawa benzoiltiourea tersubstitusi = Synthesis, analgesic .and anti-inflammatory activities of Substituted benzoylthioureas
Penelitian Ini bertujuan menentukan pengaruh. penambahan substituen pada benzoiltiourea. terhadap aktivitas farmakologis.Tiga senyawa yaitu benzoiltiourea, 4-nitrobenzoiltiourea, dan 4-klorobenzoiltiourea telah berhasil disintesis dari bahan awal amonium tlosianat, benzoil klorida tersubstitusi, dan amonia. Identifikasi struktur senyawa hasil sintesis dengan UV, IR, MS dan ¹H_ NMR. Terhadap ketiga senyawa hasil sintesis diuji aktivitas analgesik terhadap mencit, dan aktivitas anti-inflamasl terhadap tikus putih galur Wistar. Terbukti bahwa penambahan substituen p-CI dan p-N0₂meningkatkan aktivitas analgesik dan anti-inflamasi, dimana pengaruh substituen p-CI lebih besar darlpada substituen. p-N0₂. Kedua senyawa, yaitu 4-nitrobenzoiltiourea dan 4- klorobenzoiltiourea, menunjukkan aktivitas analgesik yang lebih poten tetapi efek anti-inflamasinya lebih lemah dibandingkan Na-diklofena
Synthesis, analgesic and anti-inflammatory activities of substituted benzoylthioureas
Three compounds (i.e. benzoylthiourea, 4-nitrobenzoylthiourea, and 4-chlorobenzoylthiourea) have been synthesized from ammonium thiocyanate, substituted benzoyl chlorides, and ammonia as starting materials. The structures of sythesized compounds were confirmed by means of ultra-violet, infrared, magnetic resonance, and mass spectroscopy. All compounds were evaluated for their analgesic and anti-inflamatory activities by tail-flick technique and carragenan-induced paw oedema test respectively. Substitution of p-NO2 and p-Cl group to benzoylthiourea increased the analgesic and anti-inflamatory activities. The two compounds, 4-nitrobenzoylthiourea and 4-chlorobenzoylthiourea, were significantly more potent as analgesic but their antiinflamatory actvity was weaker than Na-diclofenac.Keywords: benzoylthioureas, p-Cl dan p-NO2substituents, analgesic and anti-inflamator activitie