19 research outputs found
Stroke-Work Loss Underestimates Hemodynamic Significance of Aortic Stenosis in Patients with Hypertension
No full textEffect of negative intrathoracic pressure on left ventricular pressure dynamics and relaxation
No full textA novel inexpensive murine model of oral chronic digitalization
No full text1. A novel inexpensive murine model of oral administration of digitoxin (100 mug/kg per day) added to routine chow is described.2. Serum digitoxin levels achieved after oral (n = 5; 116 +/- 14 ng/mL) and subcutaneous (n = 5; 124 +/- 11 ng/mL) administration were similar.3. A significant increase in the maximal left ventricular pressure rise of treated (it = 9) compared with control (n = 6) rats (dP,dt: 8956 +/- 233 vs 7980 +/- 234 mmHg/s, respectively; P = 0.01) characterized the positive inotropic action of digitoxin. in addition, no differences were observed in treated compared with control rats with regard to the electrocardiogram and systolic and diastolic left ventricular pressures.Universidade Federal de São Paulo, Dept Physiol, Cardiac Physiol Lab, São Paulo, BrazilUniversidade Federal de São Paulo, Dept Physiol, Cardiac Physiol Lab, São Paulo, BrazilWeb of Scienc
Collagen remodeling of the pressure-overloaded, hypertrophied nonhuman primate myocardium.
No full textIncreased activities of prolyl 4-hydroxylase and galactosylhydroxylysyl glucosyltransferase, enzymes of collagen biosynthesis, in skeletal muscle of endurance-trained mice
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