Analysis of the dynamics and structure of morbidity of athletes of the national teams of Moscow based on the results of medical examination

Objective: The aim of the study was to analyze the structure and dynamics of morbidity of athletes, members of sports teams of the city of Moscow based on the results of an in-depth medical examination in the period 2017–2021.Materials and methods: The data of the medical examination of athletes, which took place at the Moscow scientific and Practical Center for Medical Rehabilitation, restorative and sports medicine, including instrumental, functional and laboratory studies from 2017 to 2021, were analyzed. In 2017, 15176 athletes were examined, in 2018 and 2019, 11200, in 2020, 10080 people and in 2021–11922 athletes.Results: The results of the study showed an increase in the proportion of amenorrhea within the triad of athletes, an increase in general therapeutic morbidity, diseases of the gastrointestinal tract, among which the proportion of secondary hyperbilirubinemia in 2021 increased 3 times compared to 2020, which, in our opinion, is also due to the impact of the pandemic and quarantine restrictions.The high prevalence of ophthalmological morbidity of athletes and changes in the cardiovascular system is shown. During 2017–2021, a change in the structure of cardiac morbidity was revealed in the form of an increase in the proportion of cardiac arrhythmias and hypertensive response to stress.An increase in the endocrine morbidity of athletes in 2021 was revealed due to an increase in the proportion of hypothyroidism and more frequent detection of hyperthyroidism, possibly related to the COVID-19 pandemic, which requires further research.There was also an increase in diseases of the skin and genitourinary system in athletes. Psychological problems of athletes increased during the observation period from 2017 to 2021. There was no significant dynamics of surgical and traumatological diseases, otolaryngological pathologу.Conclusion: The results of the study indicate the importance of regular full-fledged examination of athletes, identification of various functional disorders and diseases for their timely prevention and treatment in order to preserve the health of athletes and improve athletic performance

Применение нового нутрицевтика для улучшения переносимости адъювантной химиотерапии

Introduction. Treatment of malignant neoplasms often requires adjuvant chemotherapy (ACT). In real-life clinical practice, a high proportion of patients develop serious toxicities of anticancer therapy. Thus, the need to reduce treatment toxicity while maintaining the same dose levels of chemotherapeutic agents is a pressing challenge in oncology. This article presents the results of the study assessing the effects of the complex nutraceutical Oncoxin on ACT tolerability.Materials and methods. The study included 133 patients aged 50 to 70 years with stage IIB — IIIC gastric cancer or stage IIB — IIIA non-small-cell lung cancer; 84 patients received Oncoxin, and 49 were in the control group.Results. The study revealed that after two weeks, patients receiving Oncocoxin had a twice higher chance of significant (obvious) improvement in their quality of life (ESAS questionnaire) compared to the control group: OR 2.07 [95% CI 1.00-4.29]. By the end of the follow-up period (3 weeks), patients receiving Oncoxin had a significantly higher albumin level compared to the control group (38.1 [95% CI 37.1-39.1] g/L and 35.5 [95% CI 33.9-37.0], р =0.03, respectively). Moreover, the use of Oncoxin allowed significant reducing ACT-related liver toxicity.Conclusions. This study conducted within our current clinical practice showed for the first time a high efficacy of Oncoxin in improving the quality of life of patients and reducing ACT toxicity.Введение. Лечение злокачественных новообразований часто требует применения адъювантной химиотерапии (АХТ). В реальной клинической практике доля пациентов, имеющих серьёзные проявления токсичности противоопухолевого лечения, достаточно высока. Таким образом, необходимость снижения токсичности терапии и сохранение интенсивности дозы химиопрепаратов являются актуальной задачей онкологии. Данная статья посвящена результатам исследования влияния многокомпонентного нутрицевтика Онкоксин на переносимость АХТ.Материалы и методы. В исследование было включено 133 больных раком желудка МВ-ШС или немелкоклеточным раком лёгких ПВ-ША в возрасте 50- 70 лет; 84 получали Онкоксин, 49 составили контрольную группу.Результаты. Было установлено, что через две недели шансы больных, получавших Онкоксин, на значимое (безусловное) улучшение качества жизни (вопросник ESAS) были в два раза выше в сравнении с группой контроля: ОШ = 2,07 [95% ДИ 1,00- 4,29]. К окончанию периода наблюдения (3 недели) в группе пациентов, использовавших Онкоксин, уровень альбумина был значительно выше в сравнении с контрольной группой (38,1 [95% ДИ 37,1- 39,1] г /л и 35,5 [95% ДИ 33,9-37,0], р = 0,03, соответственно). Кроме этого, применение Онкоксина позволило существенно снизить печёночную токсичность АХТ.Выводы. Данное исследование, проведённое в рамках существующей клинической практики, впервые показало высокую эффективность Онкоксина в улучшении качества жизни пациентов и снижении токсичности АХТ

Nonstationary Model of Oxygen Transport in Brain Tissue

The paper addresses the mathematical study of a nonstationary continuum model describing oxygen propagation in cerebral substance. The model allows to estimate the rate of oxygen saturation and stabilization of oxygen concentration in relatively large parts of cerebral tissue. A theoretical and numerical analysis of the model is performed. The unique solvability of the underlying initial-boundary value problem for a system of coupled nonlinear parabolic equations is proved. In the numerical experiment, the tissue oxygen saturation after hypoxia is analyzed for the case when a sufficient amount of oxygen begins to flow into the capillary network. A fast stabilization of the tissue oxygen concentration is demonstrated. The reliability of the results of the numerical simulation is discussed