Non-equilibrium raft-like membrane domains under continuous recycling

We present a model for the kinetics of spontaneous membrane domain (raft) assembly that includes the effect of membrane recycling ubiquitous in living cells. We show that the domains have a broad power-law distribution with an average radius that scales with the 1/4 power of the domain lifetime when the line tension at the domain edges is large. For biologically reasonable recycling and diffusion rates the average domain radius is in the tens of nm range, consistent with observations. This represents one possible link between signaling (involving rafts) and traffic (recycling) in cells. Finally, we present evidence that suggests that the average raft size may be the same for all scale-free recycling schemes.Comment: 8 pages, 5 figure

X-ray variability analysis of a large series of XMM-Newton + NuSTAR observations of NGC 3227

We present a series of X-ray variability results from a long XMM-Newton + NuSTAR campaign on the bright, variable AGN NGC 3227. We present an analysis of the lightcurves, showing that the source displays typically softer-when-brighter behaviour, although also undergoes significant spectral hardening during one observation which we interpret as due to an occultation event by a cloud of absorbing gas. We spectrally decompose the data and show that the bulk of the variability is continuum-driven and, through rms variability analysis, strongly enhanced in the soft band. We show that the source largely conforms to linear rms-flux behaviour and we compute X-ray power spectra, detecting moderate evidence for a bend in the power spectrum, consistent with existing scaling relations. Additionally, we compute X-ray Fourier time lags using both the XMM-Newton and - through maximum-likelihood methods - NuSTAR data, revealing a strong low-frequency hard lag and evidence for a soft lag at higher frequencies, which we discuss in terms of reverberation models.Comment: Accepted for publication in MNRAS; 19 pages, 13 figures, 4 tables; minor typographical errors corrected and reference list update

Scalar Field as Dark Matter in the Universe

We investigate the hypothesis that the scalar field is the dark matter and the dark energy in the Cosmos, wich comprises about 95% of the matter of the Universe. We show that this hypothesis explains quite well the recent observations on type Ia supernovae.Comment: 4 pages REVTeX, 1 eps figure. Minor changes. To appear in Classical and Quantum Gravit

Spinor Dynamics in an Antiferromagnetic Spin-1 Condensate

We observe coherent spin oscillations in an antiferromagnetic spin-1 Bose-Einstein condensate of sodium. The variation of the spin oscillations with magnetic field shows a clear signature of nonlinearity, in agreement with theory, which also predicts anharmonic oscillations near a critical magnetic field. Measurements of the magnetic phase diagram agree with predictions made in the approximation of a single spatial mode. The oscillation period yields the best measurement to date of the sodium spin-dependent interaction coefficient, determining that the difference between the sodium spin-dependent s-wave scattering lengths $a_{f=2}-a_{f=0}$ is $2.47\pm0.27$ Bohr radii.Comment: 5 pages, 2 figures. Changes: added reference, minor correction

Strength and power training in rehabilitation: underpinning principles and practical strategies to return athletes to high performance

Injuries have a detrimental impact on team and individual athletic performance. Deficits in maximal strength, rate of force development (RFD), and reactive strength are commonly reported following several musculoskeletal injuries. This article first examines the available literature to identify common deficits in fundamental physical qualities following injury, specifically strength, rate of force development and reactive strength. Secondly, evidence-based strategies to target a resolution of these residual deficits will be discussed to reduce the risk of future injury. Examples to enhance practical application and training programmes have also been provided to show how these can be addressed

The use of Multiple Displacement Amplification to increase the detection and genotyping of <i>Trypanosoma</i> samples immobilised on FTA filters.

Whole genome amplification methods are a recently developed tool for amplifying DNA from limited template. We report its application in trypanosome infections, characterized by low parasitemias. Multiple displacement amplification (MDA) amplifies DNA with a simple in vitro step and was evaluated on mouse blood samples on FTA filter cards with known numbers of Trypanosoma brucei parasites. The data showed a 20-fold increase in the number of PCRs possible per sample, using primers diagnostic for the multicopy ribosomal ITS region or 177-bp repeats, and a 20-fold increase in sensitivity over nested PCR against a single-copy microsatellite. Using MDA for microsatellite genotyping caused allele dropout at low DNA concentrations, which was overcome by pooling multiple MDA reactions. The validity of using MDA was established with samples from Human African Trypanosomiasis patients. The use of MDA allows maximal use of finite DNA samples and may prove a valuable tool in studies where multiple reactions are necessary, such as population genetic analyses

Evidence for a Truncated Accretion Disc in the Low Luminosity Seyfert Galaxy, NGC 7213?

We present the broad-band 0.6-150 keV Suzaku and Swift BAT spectra of the low luminosity Seyfert galaxy, NGC 7213. The time-averaged continuum emission is well fitted by a single powerlaw of photon index Gamma = 1.75 and from consideration of the Fermi flux limit we constrain the high energy cutoff to be 350 keV < E < 25 MeV. Line emission from both near-neutral iron K_alpha at 6.39 keV and highly ionised iron, from Fe_(xxv) and Fe_(xxvi), is strongly detected in the Suzaku spectrum, further confirming the results of previous observations with Chandra and XMM-Newton. We find the centroid energies for the Fe_(xxv) and Fe_(xxvi) emission to be 6.60 keV and 6.95 keV respectively, with the latter appearing to be resolved in the Suzaku spectrum. We show that the Fe_(xxv) and Fe_(xxvi) emission can result from a highly photo-ionised plasma of column density N_(H) ~ 3 x 10^(23) cm^(-2). A Compton reflection component, e.g., originating from an optically-thick accretion disc or a Compton-thick torus, appears either very weak or absent in this AGN, subtending < 1 sr to the X-ray source, consistent with previous findings. Indeed the absence of either neutral or ionised Compton reflection coupled with the lack of any relativistic Fe K signatures in the spectrum suggests that an inner, optically-thick accretion disc is absent in this source. Instead, the accretion disc could be truncated with the inner regions perhaps replaced by a Compton-thin Radiatively Inefficient Accretion Flow. Thus, the Fe_(xxv) and Fe_(xxvi) emission could both originate in ionised material perhaps at the transition region between the hot, inner flow and the cold, truncated accretion disc on the order of 10^(3) - 10^(4) gravitational radii from the black hole. The origin for the unresolved neutral Fe K_alpha emission is then likely to be further out, perhaps originating in the optical BLR or a Compton-thin pc-scale torus.Comment: 15 pages, 11 figures, accepted for publication by MNRA