7 research outputs found
ΠΠΎΠ·ΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠ°Ρ ΡΡΡΡΠΊΡΡΡΠ° ΠΈ ΠΎΡΠΎΠ±Π΅Π½Π½ΠΎΡΡΠΈ ΠΈΠ½ΡΠ΅ΡΡΡΠΈΡΠΈΠ°Π»ΡΠ½ΡΡ Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΠΉ Π»Π΅Π³ΠΊΠΈΡ Ρ Π΄Π΅ΡΠ΅ΠΉ ΠΏΠ΅ΡΠ²ΡΡ 2 Π»Π΅Ρ ΠΆΠΈΠ·Π½ΠΈ: ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΡ ΠΌΠ½ΠΎΠ³ΠΎΡΠ΅Π½ΡΡΠΎΠ²ΠΎΠ³ΠΎ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ
The article presents data about study included 76 children of the first two years of life with interstitial lung diseases (ILD). According to symptoms of chILD-syndrome, all patients had respiratory signs and interstitial changes on X-ray. 93.4% of patients had respiratory symptoms, hypoxemia was revealed in 68.4% of patients by pulsoximetry. The presence of those symptoms allowed to establish chILD-syndrome in all patients, and, on the basis of clinical and laboratory-instrumental studies, nosological form was refined. Children of our study have forms of IlD such as congenital alveolar-capillary dysplasia (1.3%), pulmonary hypoplasia (17%), Wilson-Mikity syndrome (21.1%), subpleural cysts in patients with Down syndrome (6.6%), neuroendocrine cell hyperplasia of infancy (23.7%), congenital deficiency of surfactant protein B (1.3%), brain-lung-thyroid syndrome (2.6%), bronchiolitis obliterans with organizing pneumonia (10.5%), disorders related to systemic disease processes (Langerhans cell histiocytosis - 14.6%, Niemann-Pick disease - 1.3%). The features of clinical picture, data of laboratory-instrumental methods of investigation, severity of the disease's course, prognosis, predictors of the death outcome in patients with these rare diseases, have been analyzed in all patients including preterm infants.Π ΡΡΠ°ΡΡΠ΅ ΠΏΡΠΈΠ²Π΅Π΄Π΅Π½Ρ Π΄Π°Π½Π½ΡΠ΅ ΠΎΠ± ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠΈ, Π² ΠΊΠΎΡΠΎΡΠΎΠ΅ Π²ΠΎΡΠ»ΠΈ 76 Π΄Π΅ΡΠ΅ΠΉ ΠΏΠ΅ΡΠ²ΡΡ
2 Π»Π΅Ρ ΠΆΠΈΠ·Π½ΠΈ Ρ ΠΈΠ½ΡΠ΅ΡΡΡΠΈΡΠΈΠ°Π»ΡΠ½ΡΠΌΠΈ Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΡΠΌΠΈ Π»Π΅Π³ΠΊΠΈΡ
(ΠΠΠ). ΠΡΠΈ ΠΎΡΠ΅Π½ΠΊΠ΅ ΡΠΈΠΌΠΏΡΠΎΠΌΠΎΠ², Π²Ρ
ΠΎΠ΄ΡΡΠΈΡ
Π² Π΄Π΅ΡΡΠΊΠΈΠΉ ΠΠΠ-ΡΠΈΠ½Π΄ΡΠΎΠΌ, Ρ Π²ΡΠ΅Ρ
ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² Π½Π°Π±Π»ΡΠ΄Π°Π»ΠΈΡΡ ΠΎΠ±ΡΠ΅ΠΊΡΠΈΠ²Π½ΡΠ΅ ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΡΠΈΠΌΠΏΡΠΎΠΌΡ ΠΈ ΠΈΠ½ΡΠ΅ΡΡΡΠΈΡΠΈΠ°Π»ΡΠ½ΡΠ΅ ΠΈΠ·ΠΌΠ΅Π½Π΅Π½ΠΈΡ ΠΏΠΎ Π΄Π°Π½Π½ΡΠΌ ΡΠ΅Π½ΡΠ³Π΅Π½ΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠΉ. Π£ 93,4% ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² ΠΎΡΠΌΠ΅ΡΠ°Π»ΠΈΡΡ ΡΠ΅ΡΠΏΠΈΡΠ°ΡΠΎΡΠ½ΡΠ΅ ΡΠΈΠΌΠΏΡΠΎΠΌΡ, Ρ 68,4% ΠΏΠΎ Π΄Π°Π½Π½ΡΠΌ ΠΏΡΠ»ΡΡΠΎΠΊΡΠΈΠΌΠ΅ΡΡΠΈΠΈ Π±ΡΠ»Π° Π²ΡΡΠ²Π»Π΅Π½Π° Π³ΠΈΠΏΠΎΠΊΡΠ΅ΠΌΠΈΡ, ΡΡΠΎ ΠΏΠΎΠ·Π²ΠΎΠ»ΠΈΠ»ΠΎ ΡΡΡΠ°Π½ΠΎΠ²ΠΈΡΡ Π΄Π΅ΡΡΠΊΠΈΠΉ ΠΠΠ-ΡΠΈΠ½Π΄ΡΠΎΠΌ Ρ Π²ΡΠ΅Ρ
ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ², Π° Π½Π° ΠΎΡΠ½ΠΎΠ²Π°Π½ΠΈΠΈ ΠΏΡΠΎΠ²Π΅Π΄Π΅Π½Π½ΡΡ
ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΈ Π»Π°Π±ΠΎΡΠ°ΡΠΎΡΠ½ΠΎ-ΠΈΠ½ΡΡΡΡΠΌΠ΅Π½ΡΠ°Π»ΡΠ½ΡΡ
ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠΉ Π±ΡΠ»Π° ΡΡΠΎΡΠ½Π΅Π½Π° Π½ΠΎΠ·ΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠ°Ρ ΡΠΎΡΠΌΠ°. ΠΠΠ Ρ Π½Π°Π±Π»ΡΠ΄Π°Π²ΡΠΈΡ
ΡΡ Π΄Π΅ΡΠ΅ΠΉ Π²ΠΊΠ»ΡΡΠ°Π»ΠΈ Π²ΡΠΎΠΆΠ΄Π΅Π½Π½ΡΡ Π°Π»ΡΠ²Π΅ΠΎΠ»ΡΡΠ½ΠΎ-ΠΊΠ°ΠΏΠΈΠ»Π»ΡΡΠ½ΡΡ Π΄ΠΈΡΠΏΠ»Π°Π·ΠΈΡ (1,3%), Π»Π΅Π³ΠΎΡΠ½ΡΡ Π³ΠΈΠΏΠΎΠΏΠ»Π°Π·ΠΈΡ (17%), ΡΠΈΠ½Π΄ΡΠΎΠΌ ΠΠΈΠ»ΡΡΠΎΠ½Π°-ΠΠΈΠΊΠΈΡΠΈ (21,1%), ΡΡΠ±ΠΏΠ»Π΅Π²ΡΠ°Π»ΡΠ½ΡΠ΅ ΠΊΠΈΡΡΡ Ρ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² Ρ ΡΠΈΠ½Π΄ΡΠΎΠΌΠΎΠΌ ΠΠ°ΡΠ½Π° (6,6%), Π½Π΅ΠΉΡΠΎΡΠ½Π΄ΠΎΠΊΡΠΈΠ½Π½ΡΡ Π³ΠΈΠΏΠ΅ΡΠΏΠ»Π°Π·ΠΈΡ ΠΌΠ»Π°Π΄Π΅Π½ΡΠ΅Π² (23,7%), Π²ΡΠΎΠΆΠ΄Π΅Π½Π½ΡΠΉ Π΄Π΅ΡΠΈΡΠΈΡ ΡΡΡΡΠ°ΠΊΡΠ°Π½ΡΠ½ΠΎΠ³ΠΎ ΠΏΡΠΎΡΠ΅ΠΈΠ½Π° Π (1,3%), ΡΠΈΠ½Π΄ΡΠΎΠΌ Β«ΠΌΠΎΠ·Π³-Π»Π΅Π³ΠΊΠΈΠ΅-ΡΠΈΡΠΎΠ²ΠΈΠ΄Π½Π°Ρ ΠΆΠ΅Π»Π΅Π·Π°Β» (2,6%), ΠΎΠ±Π»ΠΈΡΠ΅ΡΠΈΡΡΡΡΠΈΠΉ Π±ΡΠΎΠ½Ρ
ΠΈΠΎΠ»ΠΈΡ Ρ ΠΎΡΠ³Π°Π½ΠΈΠ·ΡΡΡΠ΅ΠΉΡΡ ΠΏΠ½Π΅Π²ΠΌΠΎΠ½ΠΈΠ΅ΠΉ (10,5%), ΠΈΠ½ΡΠ΅ΡΡΡΠΈΡΠΈΠ°Π»ΡΠ½ΡΠ΅ ΠΏΠΎΡΠ°ΠΆΠ΅Π½ΠΈΡ Π»Π΅Π³ΠΊΠΈΡ
ΠΏΡΠΈ ΡΠΈΡΡΠ΅ΠΌΠ½ΡΡ
Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΡΡ
(Π³ΠΈΡΡΠΈΠΎΡΠΈΡΠΎΠ· ΠΈΠ· ΠΊΠ»Π΅ΡΠΎΠΊ ΠΠ°Π½Π³Π΅ΡΠ³Π°Π½ΡΠ° - 14,6%, Π±ΠΎΠ»Π΅Π·Π½Ρ ΠΠΈΠΌΠ°Π½Π½Π°-ΠΠΈΠΊΠ° - 1,3%). ΠΡΠΎΠ°Π½Π°Π»ΠΈΠ·ΠΈΡΠΎΠ²Π°Π½Ρ ΠΎΡΠΎΠ±Π΅Π½Π½ΠΎΡΡΠΈ ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΎΠΉ ΠΊΠ°ΡΡΠΈΠ½Ρ, Π΄Π°Π½Π½ΡΠ΅ Π»Π°Π±ΠΎΡΠ°ΡΠΎΡΠ½ΠΎΠΈΠ½ΡΡΡΡΠΌΠ΅Π½ΡΠ°Π»ΡΠ½ΡΡ
ΠΌΠ΅ΡΠΎΠ΄ΠΎΠ² ΠΎΠ±ΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ, ΡΡΠΆΠ΅ΡΡΡ ΡΠ΅ΡΠ΅Π½ΠΈΡ Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΠΉ, ΠΏΡΠΎΠ³Π½ΠΎΠ·, Π²ΡΡΠ²Π»Π΅Π½Ρ ΠΏΡΠ΅Π΄ΠΈΠΊΡΠΎΡΡ Π»Π΅ΡΠ°Π»ΡΠ½ΠΎΠ³ΠΎ ΠΈΡΡ
ΠΎΠ΄Π° Ρ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² Ρ Π΄Π°Π½Π½ΡΠΌΠΈ ΡΠ΅Π΄ΠΊΠΈΠΌΠΈ Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΡΠΌΠΈ, Π² ΡΠΎΠΌ ΡΠΈΡΠ»Π΅ Ρ Π½Π΅Π΄ΠΎΠ½ΠΎΡΠ΅Π½Π½ΡΡ
Π΄Π΅ΡΠ΅ΠΉ
ΠΠΎΠ·ΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠ°Ρ ΡΡΡΡΠΊΡΡΡΠ° ΠΈ ΠΎΡΠΎΠ±Π΅Π½Π½ΠΎΡΡΠΈ ΠΈΠ½ΡΠ΅ΡΡΡΠΈΡΠΈΠ°Π»ΡΠ½ΡΡ Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΠΉ Π»Π΅Π³ΠΊΠΈΡ Ρ Π΄Π΅ΡΠ΅ΠΉ ΠΏΠ΅ΡΠ²ΡΡ 2 Π»Π΅Ρ ΠΆΠΈΠ·Π½ΠΈ: ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΡ ΠΌΠ½ΠΎΠ³ΠΎΡΠ΅Π½ΡΡΠΎΠ²ΠΎΠ³ΠΎ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ
The article presents data about study included 76 children of the first two years of life with interstitial lung diseases (ILD). According to symptoms of chILD-syndrome, all patients had respiratory signs and interstitial changes on X-ray. 93.4% of patients had respiratory symptoms, hypoxemia was revealed in 68.4% of patients by pulsoximetry. The presence of those symptoms allowed to establish chILD-syndrome in all patients, and, on the basis of clinical and laboratory-instrumental studies, nosological form was refined. Children of our study have forms of IlD such as congenital alveolar-capillary dysplasia (1.3%), pulmonary hypoplasia (17%), Wilson-Mikity syndrome (21.1%), subpleural cysts in patients with Down syndrome (6.6%), neuroendocrine cell hyperplasia of infancy (23.7%), congenital deficiency of surfactant protein B (1.3%), brain-lung-thyroid syndrome (2.6%), bronchiolitis obliterans with organizing pneumonia (10.5%), disorders related to systemic disease processes (Langerhans cell histiocytosis - 14.6%, Niemann-Pick disease - 1.3%). The features of clinical picture, data of laboratory-instrumental methods of investigation, severity of the disease's course, prognosis, predictors of the death outcome in patients with these rare diseases, have been analyzed in all patients including preterm infants.Π ΡΡΠ°ΡΡΠ΅ ΠΏΡΠΈΠ²Π΅Π΄Π΅Π½Ρ Π΄Π°Π½Π½ΡΠ΅ ΠΎΠ± ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠΈ, Π² ΠΊΠΎΡΠΎΡΠΎΠ΅ Π²ΠΎΡΠ»ΠΈ 76 Π΄Π΅ΡΠ΅ΠΉ ΠΏΠ΅ΡΠ²ΡΡ
2 Π»Π΅Ρ ΠΆΠΈΠ·Π½ΠΈ Ρ ΠΈΠ½ΡΠ΅ΡΡΡΠΈΡΠΈΠ°Π»ΡΠ½ΡΠΌΠΈ Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΡΠΌΠΈ Π»Π΅Π³ΠΊΠΈΡ
(ΠΠΠ). ΠΡΠΈ ΠΎΡΠ΅Π½ΠΊΠ΅ ΡΠΈΠΌΠΏΡΠΎΠΌΠΎΠ², Π²Ρ
ΠΎΠ΄ΡΡΠΈΡ
Π² Π΄Π΅ΡΡΠΊΠΈΠΉ ΠΠΠ-ΡΠΈΠ½Π΄ΡΠΎΠΌ, Ρ Π²ΡΠ΅Ρ
ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² Π½Π°Π±Π»ΡΠ΄Π°Π»ΠΈΡΡ ΠΎΠ±ΡΠ΅ΠΊΡΠΈΠ²Π½ΡΠ΅ ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΡΠΈΠΌΠΏΡΠΎΠΌΡ ΠΈ ΠΈΠ½ΡΠ΅ΡΡΡΠΈΡΠΈΠ°Π»ΡΠ½ΡΠ΅ ΠΈΠ·ΠΌΠ΅Π½Π΅Π½ΠΈΡ ΠΏΠΎ Π΄Π°Π½Π½ΡΠΌ ΡΠ΅Π½ΡΠ³Π΅Π½ΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠΉ. Π£ 93,4% ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² ΠΎΡΠΌΠ΅ΡΠ°Π»ΠΈΡΡ ΡΠ΅ΡΠΏΠΈΡΠ°ΡΠΎΡΠ½ΡΠ΅ ΡΠΈΠΌΠΏΡΠΎΠΌΡ, Ρ 68,4% ΠΏΠΎ Π΄Π°Π½Π½ΡΠΌ ΠΏΡΠ»ΡΡΠΎΠΊΡΠΈΠΌΠ΅ΡΡΠΈΠΈ Π±ΡΠ»Π° Π²ΡΡΠ²Π»Π΅Π½Π° Π³ΠΈΠΏΠΎΠΊΡΠ΅ΠΌΠΈΡ, ΡΡΠΎ ΠΏΠΎΠ·Π²ΠΎΠ»ΠΈΠ»ΠΎ ΡΡΡΠ°Π½ΠΎΠ²ΠΈΡΡ Π΄Π΅ΡΡΠΊΠΈΠΉ ΠΠΠ-ΡΠΈΠ½Π΄ΡΠΎΠΌ Ρ Π²ΡΠ΅Ρ
ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ², Π° Π½Π° ΠΎΡΠ½ΠΎΠ²Π°Π½ΠΈΠΈ ΠΏΡΠΎΠ²Π΅Π΄Π΅Π½Π½ΡΡ
ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΈ Π»Π°Π±ΠΎΡΠ°ΡΠΎΡΠ½ΠΎ-ΠΈΠ½ΡΡΡΡΠΌΠ΅Π½ΡΠ°Π»ΡΠ½ΡΡ
ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠΉ Π±ΡΠ»Π° ΡΡΠΎΡΠ½Π΅Π½Π° Π½ΠΎΠ·ΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠ°Ρ ΡΠΎΡΠΌΠ°. ΠΠΠ Ρ Π½Π°Π±Π»ΡΠ΄Π°Π²ΡΠΈΡ
ΡΡ Π΄Π΅ΡΠ΅ΠΉ Π²ΠΊΠ»ΡΡΠ°Π»ΠΈ Π²ΡΠΎΠΆΠ΄Π΅Π½Π½ΡΡ Π°Π»ΡΠ²Π΅ΠΎΠ»ΡΡΠ½ΠΎ-ΠΊΠ°ΠΏΠΈΠ»Π»ΡΡΠ½ΡΡ Π΄ΠΈΡΠΏΠ»Π°Π·ΠΈΡ (1,3%), Π»Π΅Π³ΠΎΡΠ½ΡΡ Π³ΠΈΠΏΠΎΠΏΠ»Π°Π·ΠΈΡ (17%), ΡΠΈΠ½Π΄ΡΠΎΠΌ ΠΠΈΠ»ΡΡΠΎΠ½Π°-ΠΠΈΠΊΠΈΡΠΈ (21,1%), ΡΡΠ±ΠΏΠ»Π΅Π²ΡΠ°Π»ΡΠ½ΡΠ΅ ΠΊΠΈΡΡΡ Ρ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² Ρ ΡΠΈΠ½Π΄ΡΠΎΠΌΠΎΠΌ ΠΠ°ΡΠ½Π° (6,6%), Π½Π΅ΠΉΡΠΎΡΠ½Π΄ΠΎΠΊΡΠΈΠ½Π½ΡΡ Π³ΠΈΠΏΠ΅ΡΠΏΠ»Π°Π·ΠΈΡ ΠΌΠ»Π°Π΄Π΅Π½ΡΠ΅Π² (23,7%), Π²ΡΠΎΠΆΠ΄Π΅Π½Π½ΡΠΉ Π΄Π΅ΡΠΈΡΠΈΡ ΡΡΡΡΠ°ΠΊΡΠ°Π½ΡΠ½ΠΎΠ³ΠΎ ΠΏΡΠΎΡΠ΅ΠΈΠ½Π° Π (1,3%), ΡΠΈΠ½Π΄ΡΠΎΠΌ Β«ΠΌΠΎΠ·Π³-Π»Π΅Π³ΠΊΠΈΠ΅-ΡΠΈΡΠΎΠ²ΠΈΠ΄Π½Π°Ρ ΠΆΠ΅Π»Π΅Π·Π°Β» (2,6%), ΠΎΠ±Π»ΠΈΡΠ΅ΡΠΈΡΡΡΡΠΈΠΉ Π±ΡΠΎΠ½Ρ
ΠΈΠΎΠ»ΠΈΡ Ρ ΠΎΡΠ³Π°Π½ΠΈΠ·ΡΡΡΠ΅ΠΉΡΡ ΠΏΠ½Π΅Π²ΠΌΠΎΠ½ΠΈΠ΅ΠΉ (10,5%), ΠΈΠ½ΡΠ΅ΡΡΡΠΈΡΠΈΠ°Π»ΡΠ½ΡΠ΅ ΠΏΠΎΡΠ°ΠΆΠ΅Π½ΠΈΡ Π»Π΅Π³ΠΊΠΈΡ
ΠΏΡΠΈ ΡΠΈΡΡΠ΅ΠΌΠ½ΡΡ
Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΡΡ
(Π³ΠΈΡΡΠΈΠΎΡΠΈΡΠΎΠ· ΠΈΠ· ΠΊΠ»Π΅ΡΠΎΠΊ ΠΠ°Π½Π³Π΅ΡΠ³Π°Π½ΡΠ° - 14,6%, Π±ΠΎΠ»Π΅Π·Π½Ρ ΠΠΈΠΌΠ°Π½Π½Π°-ΠΠΈΠΊΠ° - 1,3%). ΠΡΠΎΠ°Π½Π°Π»ΠΈΠ·ΠΈΡΠΎΠ²Π°Π½Ρ ΠΎΡΠΎΠ±Π΅Π½Π½ΠΎΡΡΠΈ ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΎΠΉ ΠΊΠ°ΡΡΠΈΠ½Ρ, Π΄Π°Π½Π½ΡΠ΅ Π»Π°Π±ΠΎΡΠ°ΡΠΎΡΠ½ΠΎΠΈΠ½ΡΡΡΡΠΌΠ΅Π½ΡΠ°Π»ΡΠ½ΡΡ
ΠΌΠ΅ΡΠΎΠ΄ΠΎΠ² ΠΎΠ±ΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ, ΡΡΠΆΠ΅ΡΡΡ ΡΠ΅ΡΠ΅Π½ΠΈΡ Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΠΉ, ΠΏΡΠΎΠ³Π½ΠΎΠ·, Π²ΡΡΠ²Π»Π΅Π½Ρ ΠΏΡΠ΅Π΄ΠΈΠΊΡΠΎΡΡ Π»Π΅ΡΠ°Π»ΡΠ½ΠΎΠ³ΠΎ ΠΈΡΡ
ΠΎΠ΄Π° Ρ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² Ρ Π΄Π°Π½Π½ΡΠΌΠΈ ΡΠ΅Π΄ΠΊΠΈΠΌΠΈ Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΡΠΌΠΈ, Π² ΡΠΎΠΌ ΡΠΈΡΠ»Π΅ Ρ Π½Π΅Π΄ΠΎΠ½ΠΎΡΠ΅Π½Π½ΡΡ
Π΄Π΅ΡΠ΅ΠΉ
Π§Π°ΡΡΠΎΡΠ°, ΡΠ°ΠΊΡΠΎΡΡ ΡΠΈΡΠΊΠ°, ΠΎΡΠΎΠ±Π΅Π½Π½ΠΎΡΡΠΈ Π±ΡΠΎΠ½Ρ ΠΈΠ°Π»ΡΠ½ΠΎΠΉ Π°ΡΡΠΌΡ Ρ Π΄Π΅ΡΠ΅ΠΉ Ρ Π±ΡΠΎΠ½Ρ ΠΎΠ»Π΅Π³ΠΎΡΠ½ΠΎΠΉ Π΄ΠΈΡΠΏΠ»Π°Π·ΠΈΠ΅ΠΉ ΠΈ Π²Π΅Π΄Π΅Π½ΠΈΠ΅ ΠΊΠΎΠΌΠΎΡΠ±ΠΈΠ΄Π½ΡΡ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ²
Bronchopulmonary dysplasia (BPD) and bronchial asthma (BA) are the most common chronic lung diseases in children, but the relationship between these diseases has not been fully defined. The incidence of atopic diseases (atopic dermatitis, allergic rhinitis, and BA) in children with BPD are significantly different according to national and international studies. There is not enough data on risk factors for the development, clinical and laboratory features of the course and treatment of BA in children with BPD. Material and methods. The case histories of 1104 patients (2004-2017) with BPD criteria were analyzed at the Department of Pediatrics at the RUDN University. On the basis of clinical and anamnestic data, allergological examination, and study of respiratory function, the frequency of asthma was determined. The comparative study was conducted in patients with isolated diseases - BPD (without BA) and BA (without BPD) - to determine the risk factors and characteristics of BA in children with BPD. Results and discussion. The frequency of BA was 7%, atopic dermatitis - 3.8% and allergic rhinitis - 3.6%. The risk factors for the development of BA in children with BPD were determined for low birth weight (LBW) (p=0.0037), late prematurity (p=0.0007), family history of allergy through asthma (p=0.0334), concomitant atopic dermatitis (p=0.0018) and allergic rhinitis (p=0.0022). Severe BPD (p=0.0002), episodes of bronchial obstruction in the first 3 years of life (p=0.0272). It was found that BA in children with BPD, compared with children without BPD is statistically significant. It characterized by an earlier onset (p=0.0168), a mild intermittent course (p=0.0003), a rarer need for inhaled bronchodilators (p=0.0034) and more frequent administration of inhaled corticosteroids as basic therapy (p=0.0399). Conclusion. We suggested that BA in children could be a respiratory consequence of BPD and a comorbid disease with a separate phenotype. The management of children suffering from BA and BPD should include the registration and evaluation of epidemiology, risk factors, clinical and laboratory features. It would be necessary to implement the clinical and allergological examination and the development of an individualized management program for patients.ΠΡΠΎΠ½Ρ
ΠΎΠ»Π΅Π³ΠΎΡΠ½Π°Ρ Π΄ΠΈΡΠΏΠ»Π°Π·ΠΈΡ (ΠΠΠ) ΠΈ Π±ΡΠΎΠ½Ρ
ΠΈΠ°Π»ΡΠ½Π°Ρ Π°ΡΡΠΌΠ° (ΠΠ) ΡΠ²Π»ΡΡΡΡΡ ΡΠ°ΠΌΡΠΌΠΈ ΡΠ°ΡΡΡΠΌΠΈ Ρ
ΡΠΎΠ½ΠΈΡΠ΅ΡΠΊΠΈΠΌΠΈ Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΡΠΌΠΈ Π»Π΅Π³ΠΊΠΈΡ
Ρ Π΄Π΅ΡΠ΅ΠΉ, ΠΎΠ΄Π½Π°ΠΊΠΎ ΡΠ²ΡΠ·Ρ ΠΌΠ΅ΠΆΠ΄Ρ Π΄Π°Π½Π½ΡΠΌΠΈ Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΡΠΌΠΈ Π΄ΠΎ ΠΊΠΎΠ½ΡΠ° Π½Π΅ ΠΎΠΏΡΠ΅Π΄Π΅Π»Π΅Π½Π°. Π§Π°ΡΡΠΎΡΠ° ΡΠ°Π·Π²ΠΈΡΠΈΡ Π°ΡΠΎΠΏΠΈΡΠ΅ΡΠΊΠΈΡ
Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΠΉ (Π°ΡΠΎΠΏΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ Π΄Π΅ΡΠΌΠ°ΡΠΈΡΠ°, Π°Π»Π»Π΅ΡΠ³ΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΡΠΈΠ½ΠΈΡΠ° ΠΈ ΠΠ) Ρ Π΄Π΅ΡΠ΅ΠΉ Ρ ΠΠΠ ΡΡΡΠ΅ΡΡΠ²Π΅Π½Π½ΠΎ ΠΎΡΠ»ΠΈΡΠ°Π΅ΡΡΡ; ΠΏΠΎ Π΄Π°Π½Π½ΡΠΌ ΠΎΡΠ΅ΡΠ΅ΡΡΠ²Π΅Π½Π½ΡΡ
ΠΈ Π·Π°ΡΡΠ±Π΅ΠΆΠ½ΡΡ
ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠΉ, Π½Π΅ΠΌΠ½ΠΎΠ³ΠΎΡΠΈΡΠ»Π΅Π½Ρ Π΄Π°Π½Π½ΡΠ΅ ΠΎ ΡΠ°ΠΊΡΠΎΡΠ°Ρ
ΡΠΈΡΠΊΠ° ΡΠ°Π·Π²ΠΈΡΠΈΡ, ΠΊΠ»ΠΈΠ½ΠΈΠΊΠΎ-Π»Π°Π±ΠΎΡΠ°ΡΠΎΡΠ½ΡΡ
ΠΎΡΠΎΠ±Π΅Π½Π½ΠΎΡΡΡΡ
ΡΠ΅ΡΠ΅Π½ΠΈΡ ΠΈ ΡΠ΅ΡΠ°ΠΏΠΈΠΈ ΠΠ Ρ Π΄Π΅ΡΠ΅ΠΉ Ρ ΠΠΠ. ΠΠ°ΡΠ΅ΡΠΈΠ°Π» ΠΈ ΠΌΠ΅ΡΠΎΠ΄Ρ. ΠΡΠ»ΠΈ ΠΈΠ·ΡΡΠ΅Π½Ρ ΠΈΡΡΠΎΡΠΈΠΈ Π±ΠΎΠ»Π΅Π·Π½Π΅ΠΉ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² Ρ ΠΠΠ ΠΈ ΠΠΠ Π² Π°Π½Π°ΠΌΠ½Π΅Π·Π΅, Π½Π°Π±Π»ΡΠ΄Π°Π²ΡΠΈΡ
ΡΡ Π½Π° ΠΊΠ°ΡΠ΅Π΄ΡΠ΅ ΠΏΠ΅Π΄ΠΈΠ°ΡΡΠΈΠΈ Π€ΠΠΠΠ£ ΠΠ Β«Π ΠΎΡΡΠΈΠΉΡΠΊΠΈΠΉ ΡΠ½ΠΈΠ²Π΅ΡΡΠΈΡΠ΅Ρ Π΄ΡΡΠΆΠ±Ρ Π½Π°ΡΠΎΠ΄ΠΎΠ²Β» (ΠΠΎΡΠΊΠ²Π°) Π½Π° Π±Π°Π·Π΅ ΠΊΠΎΠ½ΡΡΠ»ΡΡΠ°ΡΠΈΠ²Π½ΠΎ-Π΄ΠΈΠ°Π³Π½ΠΎΡΡΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΠΎΡΠ΄Π΅Π»Π΅Π½ΠΈΡ Ρ Π΄Π½Π΅Π²Π½ΡΠΌ ΡΡΠ°ΡΠΈΠΎΠ½Π°ΡΠΎΠΌ ΠΠΠ£Π Β«ΠΠ΅ΡΡΠΊΠ°Ρ ΠΈΠ½ΡΠ΅ΠΊΡΠΈΠΎΠ½Π½Π°Ρ ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠ°Ρ Π±ΠΎΠ»ΡΠ½ΠΈΡΠ° β 6Β» ΠΠ΅ΠΏΠ°ΡΡΠ°ΠΌΠ΅Π½ΡΠ° Π·Π΄ΡΠ°Π²ΠΎΠΎΡ
ΡΠ°Π½Π΅Π½ΠΈΡ Π³. ΠΠΎΡΠΊΠ²Ρ Ρ 2004 ΠΏΠΎ 2017 Π³. Π‘ΡΠ΅Π΄ΠΈ ΡΡΠΈΡ
Π±ΠΎΠ»ΡΠ½ΡΡ
Π½Π° ΠΎΡΠ½ΠΎΠ²Π°Π½ΠΈΠΈ ΠΊΠ»ΠΈΠ½ΠΈΠΊΠΎ-Π°Π½Π°ΠΌΠ½Π΅ΡΡΠΈΡΠ΅ΡΠΊΠΈΡ
Π΄Π°Π½Π½ΡΡ
, Π°Π»Π»Π΅ΡΠ³ΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΠΎΠ±ΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ ΠΈ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ ΡΡΠ½ΠΊΡΠΈΠΈ Π²Π½Π΅ΡΠ½Π΅Π³ΠΎ Π΄ΡΡ
Π°Π½ΠΈΡ ΠΎΠΏΡΠ΅Π΄Π΅Π»Π΅Π½Π° ΡΠ°ΡΡΠΎΡΠ° ΠΠ, ΠΏΡΠΎΠ²Π΅Π΄Π΅Π½ΠΎ ΡΡΠ°Π²Π½ΠΈΡΠ΅Π»ΡΠ½ΠΎΠ΅ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠ΅ Ρ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠ°ΠΌΠΈ Ρ ΠΈΠ·ΠΎΠ»ΠΈΡΠΎΠ²Π°Π½Π½ΡΠΌΠΈ Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΡΠΌΠΈ: ΠΠΠ (Π±Π΅Π· ΠΠ) ΠΈ ΠΠ (Π±Π΅Π· ΠΠΠ) Π΄Π»Ρ ΠΎΠΏΡΠ΅Π΄Π΅Π»Π΅Π½ΠΈΡ ΡΠ°ΠΊΡΠΎΡΠΎΠ² ΡΠΈΡΠΊΠ° ΠΈ ΠΎΡΠΎΠ±Π΅Π½Π½ΠΎΡΡΠ΅ΠΉ ΠΠ Ρ Π΄Π΅ΡΠ΅ΠΉ Ρ ΠΠΠ. Π Π΅Π·ΡΠ»ΡΡΠ°ΡΡ ΠΈ ΠΎΠ±ΡΡΠΆΠ΄Π΅Π½ΠΈΠ΅. ΠΡΠΎΠ°Π½Π°Π»ΠΈΠ·ΠΈΡΠΎΠ²Π°Π½ΠΎ 1104 ΠΌΠ΅Π΄ΠΈΡΠΈΠ½ΡΠΊΠΈΡ
ΠΊΠ°ΡΡ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ², ΡΠ΄ΠΎΠ²Π»Π΅ΡΠ²ΠΎΡΡΡΡΠΈΡ
ΠΊΡΠΈΡΠ΅ΡΠΈΡΠΌ Π΄ΠΈΠ°Π³Π½ΠΎΠ·Π° ΠΠΠ, ΠΎΠΏΡΠ΅Π΄Π΅Π»Π΅Π½Π° ΡΠ°ΡΡΠΎΡΠ° ΡΠ°Π·Π²ΠΈΡΠΈΡ Ρ Π½ΠΈΡ
Π°ΡΠΎΠΏΠΈΡΠ΅ΡΠΊΠΈΡ
Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΠΉ. Π§Π°ΡΡΠΎΡΠ° ΠΠ ΡΠΎΡΡΠ°Π²ΠΈΠ»Π° 7%, Π°ΡΠΎΠΏΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ Π΄Π΅ΡΠΌΠ°ΡΠΈΡΠ° - 3,8%, Π°Π»Π»Π΅ΡΠ³ΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΡΠΈΠ½ΠΈΡΠ° - 3,6%. ΠΠΏΡΠ΅Π΄Π΅Π»Π΅Π½Ρ ΡΠ°ΠΊΡΠΎΡΡ ΡΠΈΡΠΊΠ° ΡΠ°Π·Π²ΠΈΡΠΈΡ ΠΠ Ρ Π΄Π΅ΡΠ΅ΠΉ Ρ ΠΠΠ: Π½ΠΈΠ·ΠΊΠ°Ρ ΠΌΠ°ΡΡΠ° ΡΠ΅Π»Π° ΠΏΡΠΈ ΡΠΎΠΆΠ΄Π΅Π½ΠΈΠΈ (Ρ=0,0037), ΠΏΠΎΠ·Π΄Π½ΡΡ Π½Π΅Π΄ΠΎΠ½ΠΎΡΠ΅Π½Π½ΠΎΡΡΡ (Ρ=0,0007), ΠΎΡΡΠ³ΠΎΡΠ΅Π½Π½ΡΠΉ ΡΠ΅ΠΌΠ΅ΠΉΠ½ΡΠΉ Π°Π»Π»Π΅ΡΠ³ΠΎΠ°Π½Π°ΠΌΠ½Π΅Π· ΠΏΠΎ ΠΠ (Ρ=0,0334), ΡΠΎΠΏΡΡΡΡΠ²ΡΡΡΠΈΠ΅ Π°ΡΠΎΠΏΠΈΡΠ΅ΡΠΊΠΈΠΉ Π΄Π΅ΡΠΌΠ°ΡΠΈΡ (Ρ=0,0018) ΠΈ Π°Π»Π»Π΅ΡΠ³ΠΈΡΠ΅ΡΠΊΠΈΠΉ ΡΠΈΠ½ΠΈΡ (Ρ=0,0022), ΡΡΠΆΠ΅Π»Π°Ρ ΠΠΠ (Ρ=0,0002), ΡΠΏΠΈΠ·ΠΎΠ΄Ρ Π±ΡΠΎΠ½Ρ
ΠΈΠ°Π»ΡΠ½ΠΎΠΉ ΠΎΠ±ΡΡΡΡΠΊΡΠΈΠΈ Π² ΠΏΠ΅ΡΠ²ΡΠ΅ 3 Π³ΠΎΠ΄Π° ΠΆΠΈΠ·Π½ΠΈ (Ρ=0,0272). Π£ΡΡΠ°Π½ΠΎΠ²Π»Π΅Π½ΠΎ, ΡΡΠΎ ΠΠ Ρ Π΄Π΅ΡΠ΅ΠΉ Ρ ΠΠΠ ΠΏΠΎ ΡΡΠ°Π²Π½Π΅Π½ΠΈΡ Ρ Π΄Π΅ΡΡΠΌΠΈ Π±Π΅Π· Π΄Π°Π½Π½ΠΎΠ³ΠΎ Ρ
ΡΠΎΠ½ΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΡ Π»Π΅Π³ΠΊΠΈΡ
Π½ΠΎΠ²ΠΎΡΠΎΠΆΠ΄Π΅Π½Π½ΡΡ
ΡΡΠ°ΡΠΈΡΡΠΈΡΠ΅ΡΠΊΠΈ Π·Π½Π°ΡΠΈΠΌΠΎ ΡΠ°ΡΠ΅ Ρ
Π°ΡΠ°ΠΊΡΠ΅ΡΠΈΠ·ΡΠ΅ΡΡΡ Π±ΠΎΠ»Π΅Π΅ ΡΠ°Π½Π½ΠΈΠΌ Π½Π°ΡΠ°Π»ΠΎΠΌ (Ρ=0,0168), Π»Π΅Π³ΠΊΠΈΠΌ ΠΈΠ½ΡΠ΅ΡΠΌΠΈΡΡΠΈΡΡΡΡΠΈΠΌ ΡΠ΅ΡΠ΅Π½ΠΈΠ΅ΠΌ (Ρ=0,0003), Π±ΠΎΠ»Π΅Π΅ ΡΠ΅Π΄ΠΊΠΎΠΉ ΠΏΠΎΡΡΠ΅Π±Π½ΠΎΡΡΡΡ Π² ΠΈΠ½Π³Π°Π»ΡΡΠΈΠΎΠ½Π½ΡΡ
Π±ΡΠΎΠ½Ρ
ΠΎΠ»ΠΈΡΠΈΠΊΠ°Ρ
(Ρ=0,0034) ΠΈ Π±ΠΎΠ»Π΅Π΅ ΡΠ°ΡΡΡΠΌ Π½Π°Π·Π½Π°ΡΠ΅Π½ΠΈΠ΅ΠΌ ΠΈΠ½Π³Π°Π»ΡΡΠΈΠΎΠ½Π½ΡΡ
Π³Π»ΡΠΊΠΎΠΊΠΎΡΡΠΈΠΊΠΎΠΈΠ΄ΠΎΠ² Π² ΠΊΠ°ΡΠ΅ΡΡΠ²Π΅ Π±Π°Π·ΠΈΡΠ½ΠΎΠΉ ΡΠ΅ΡΠ°ΠΏΠΈΠΈ (Ρ=0,0399). ΠΠ°ΠΊΠ»ΡΡΠ΅Π½ΠΈΠ΅. ΠΠ Ρ Π΄Π΅ΡΠ΅ΠΉ ΡΠ²Π»ΡΠ΅ΡΡΡ ΡΠ΅ΡΠΏΠΈΡΠ°ΡΠΎΡΠ½ΡΠΌ ΠΏΠΎΡΠ»Π΅Π΄ΡΡΠ²ΠΈΠ΅ΠΌ ΠΠΠ, ΠΊΠΎΠΌΠΎΡΠ±ΠΈΠ΄Π½ΡΠΌ Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΠ΅ΠΌ Ρ ΠΎΡΠ΄Π΅Π»ΡΠ½ΡΠΌ ΡΠ΅Π½ΠΎΡΠΈΠΏΠΎΠΌ. ΠΠΊΠ°Π·Π°Π½ΠΈΠ΅ ΠΌΠ΅Π΄ΠΈΡΠΈΠ½ΡΠΊΠΎΠΉ ΠΏΠΎΠΌΠΎΡΠΈ Π΄Π΅ΡΡΠΌ, ΡΡΡΠ°Π΄Π°ΡΡΠΈΠΌ ΠΠ ΠΈ ΠΠΠ, Π΄ΠΎΠ»ΠΆΠ½ΠΎ ΠΏΡΠ΅Π΄ΡΡΠΌΠ°ΡΡΠΈΠ²Π°ΡΡ ΡΡΠ΅Ρ ΠΈ ΠΎΡΠ΅Π½ΠΊΡ ΡΠΏΠΈΠ΄Π΅ΠΌΠΈΠΎΠ»ΠΎΠ³ΠΈΠΈ, ΡΠ°ΠΊΡΠΎΡΠΎΠ² ΡΠΈΡΠΊΠ° ΡΠ°Π·Π²ΠΈΡΠΈΡ, ΠΊΠ»ΠΈΠ½ΠΈΠΊΠΎ-Π»Π°Π±ΠΎΡΠ°ΡΠΎΡΠ½ΡΡ
ΠΎΡΠΎΠ±Π΅Π½Π½ΠΎΡΡΠ΅ΠΉ Ρ ΡΠ΅Π°Π»ΠΈΠ·Π°ΡΠΈΠ΅ΠΉ ΡΡΠ°ΠΏΠ½ΠΎΠ³ΠΎ ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΠΈ Π°Π»Π»Π΅ΡΠ³ΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΠΎΠ±ΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ ΠΈ Π²ΡΡΠ°Π±ΠΎΡΠΊΠΎΠΉ ΠΏΡΠΎΠ³ΡΠ°ΠΌΠΌΡ ΠΈΠ½Π΄ΠΈΠ²ΠΈΠ΄ΡΠ°Π»ΠΈΠ·ΠΈΡΠΎΠ²Π°Π½Π½ΠΎΠ³ΠΎ Π²Π΅Π΄Π΅Π½ΠΈΡ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ²
The structure of interstitial lung diseases in children of the first two years of life
For the first time in Russia, the article provides data on interstitial lung diseases structure in children of the first two years of life, based on a series of observations of 68 patients with these rare diseases, as a part of multi-center ambispective study. Interstitial lung diseases in observed children included: Wilson-Mikity syndrome (23,4%), neuroendocrine hyperplasia of infancy (22%), bronchiolitis obliterans with organizing pneumonia (7,4%), primary pulmonary hypoplasia (1,5%), secondary pulmonary hypoplasia with Jeune syndrome (10,3%), secondary pulmonary hypoplasia with Edwards syndrome (2,9%), secondary pulmonary hypoplasia with other associated pathology (omphalocele - 1,5%, non-immune fetal hydrops - 1,5%), subpleural cysts in patients with Down syndrome (5,9%), congenital deficiency of surfactant protein B (1,5%), brain-lung- thyroid syndrome (2,9%), congenital alveolar-capillary dysplasia (1,5%), interstitial lung diseases with systemic diseases (Langerhans cell histiocytosis - 16,2%, Niemann-Pick disease - 1,5%). The article summarizes clinical features, the results of image diagnosis and disease outcomes. Β© 2015, Pediatria Ltd. All rights reserved
In children with bronchial asthma: Causal, complicated, unspecified, reverse
The review, based on modern literature data and the results of many years of research conducted by the authors, highlights the problem of comorbidity (multimorbidity) in children with bronchial asthma (BA). There is a grouping of concomitant diseases in children with asthma depending on the type of comorbidity (causal, complicated, unspecified, reverse). Based on epidemiological data, observational and cohort studies, systematic reviews and meta-analyses, information on the frequency of BA in children with various comorbid diseases and comorbid diseases in children with BA was summarized. Scientific, theoretical and practical significance of comorbidity in BA, diagnostic and treatment programs in pediatric patients suffering from BA and comorbid diseases are substantiated. Β© 2021, Pediatria Ltd.. All rights reserved
The structure of interstitial lung diseases in children of the first two years of life
For the first time in Russia, the article provides data on interstitial lung diseases structure in children of the first two years of life, based on a series of observations of 68 patients with these rare diseases, as a part of multi-center ambispective study. Interstitial lung diseases in observed children included: Wilson-Mikity syndrome (23,4%), neuroendocrine hyperplasia of infancy (22%), bronchiolitis obliterans with organizing pneumonia (7,4%), primary pulmonary hypoplasia (1,5%), secondary pulmonary hypoplasia with Jeune syndrome (10,3%), secondary pulmonary hypoplasia with Edwards syndrome (2,9%), secondary pulmonary hypoplasia with other associated pathology (omphalocele - 1,5%, non-immune fetal hydrops - 1,5%), subpleural cysts in patients with Down syndrome (5,9%), congenital deficiency of surfactant protein B (1,5%), brain-lung- thyroid syndrome (2,9%), congenital alveolar-capillary dysplasia (1,5%), interstitial lung diseases with systemic diseases (Langerhans cell histiocytosis - 16,2%, Niemann-Pick disease - 1,5%). The article summarizes clinical features, the results of image diagnosis and disease outcomes. Β© 2015, Pediatria Ltd. All rights reserved
2021 Taxonomic update of phylum Negarnaviricota (Riboviria: Orthornavirae), including the large orders Bunyavirales and Mononegavirales
In March 2021, following the annual International Committee on Taxonomy of Viruses (ICTV) ratification vote on newly proposed taxa, the phylum Negarnaviricota was amended and emended. The phylum was expanded by four families (Aliusviridae, Crepuscuviridae, Myriaviridae, and Natareviridae), three subfamilies (Alpharhabdovirinae, Betarhabdovirinae, and Gammarhabdovirinae), 42 genera, and 200 species. Thirty-nine species were renamed and/or moved and seven species were abolished. This article presents the updated taxonomy of Negarnaviricota as now accepted by the ICTV