113 research outputs found

    A unified first-principles study of Gilbert damping, spin-flip diffusion and resistivity in transition metal alloys

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    Using a formulation of first-principles scattering theory that includes disorder and spin-orbit coupling on an equal footing, we calculate the resistivity ρ\rho, spin flip diffusion length lsfl_{sf} and the Gilbert damping parameter α\alpha for Ni1x_{1-x}Fex_x substitutional alloys as a function of xx. For the technologically important Ni80_{80}Fe20_{20} alloy, permalloy, we calculate values of ρ=3.5±0.15\rho = 3.5 \pm 0.15 μ\muOhm-cm, lsf=5.5±0.3l_{sf}=5.5 \pm 0.3 nm, and α=0.0046±0.0001\alpha= 0.0046 \pm 0.0001 compared to experimental low-temperature values in the range 4.24.84.2-4.8 μ\muOhm-cm for ρ\rho, 5.06.05.0-6.0 nm for lsfl_{sf}, and 0.0040.0130.004-0.013 for α\alpha indicating that the theoretical formalism captures the most important contributions to these parameters.Comment: Published in Physical Review Letter

    First-principles calculations of magnetization relaxation in pure Fe, Co, and Ni with frozen thermal lattice disorder

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    The effect of the electron-phonon interaction on magnetization relaxation is studied within the framework of first-principles scattering theory for Fe, Co, and Ni by displacing atoms in the scattering region randomly with a thermal distribution. This "frozen thermal lattice disorder" approach reproduces the non-monotonic damping behaviour observed in ferromagnetic resonance measurements and yields reasonable quantitative agreement between calculated and experimental values. It can be readily applied to alloys and easily extended by determining the atomic displacements from ab initio phonon spectra

    Fate of iPSCs Derived from Azoospermic and Fertile Men following Xenotransplantation to Murine Seminiferous Tubules

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    SummaryHistorically, spontaneous deletions and insertions have provided means to probe germline developmental genetics in Drosophila, mouse and other species. Here, induced pluripotent stem cell (iPSC) lines were derived from infertile men with deletions that encompass three Y chromosome azoospermia factor (AZF) regions and are associated with production of few or no sperm but normal somatic development. AZF-deleted iPSC lines were compromised in germ cell development in vitro. Undifferentiated iPSCs transplanted directly into murine seminiferous tubules differentiated extensively to germ-cell-like cells (GCLCs) that localized near the basement membrane, demonstrated morphology indistinguishable from fetal germ cells, and expressed germ-cell-specific proteins diagnostic of primordial germ cells. Alternatively, all iPSCs that exited tubules formed primitive tumors. iPSCs with AZF deletions produced significantly fewer GCLCs in vivo with distinct defects in gene expression. Findings indicate that xenotransplantation of human iPSCs directs germ cell differentiation in a manner dependent on donor genetic status

    Thermoelectric Effects in Magnetic Nanostructures

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    We model and evaluate the Peltier and Seebeck effects in magnetic multilayer nanostructures by a finite-element theory of thermoelectric properties. We present analytical expressions for the thermopower and the current-induced temperature changes due to Peltier cooling/heating. The thermopower of a magnetic element is in general spin-polarized, leading to spin-heat coupling effects. Thermoelectric effects in spin valves depend on the relative alignment of the magnetization directions and are sensitive to spin-flip scattering as well as inelastic collisions in the normal metal spacer.Comment: 14 pages, 7 figures, 1 table. Publishe

    Scattering theory of interface resistance in magnetic multilayers

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    The scattering theory of transport has to be applied with care in a diffuse environment. Here we discuss how the scattering matrices of heterointerfaces can be used to compute interface resistances of dirty magnetic multilayers. First principles calculations of these interface resistances agree well with experiments in the CPP (current perpendicular to the interface plane) configuration.Comment: submitted to J. Phys. D (special issue at the occasion of Prof. T. Shinjo's 60th birthday

    Reagent and laboratory contamination can critically impact sequence-based microbiome analyses.

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    BACKGROUND: The study of microbial communities has been revolutionised in recent years by the widespread adoption of culture independent analytical techniques such as 16S rRNA gene sequencing and metagenomics. One potential confounder of these sequence-based approaches is the presence of contamination in DNA extraction kits and other laboratory reagents. RESULTS: In this study we demonstrate that contaminating DNA is ubiquitous in commonly used DNA extraction kits and other laboratory reagents, varies greatly in composition between different kits and kit batches, and that this contamination critically impacts results obtained from samples containing a low microbial biomass. Contamination impacts both PCR-based 16S rRNA gene surveys and shotgun metagenomics. We provide an extensive list of potential contaminating genera, and guidelines on how to mitigate the effects of contamination. CONCLUSIONS: These results suggest that caution should be advised when applying sequence-based techniques to the study of microbiota present in low biomass environments. Concurrent sequencing of negative control samples is strongly advised

    Novel missense mutations of the Deleted-in-AZoospermia-Like (DAZL) gene in infertile women and men

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    BACKGROUND: The Deleted-in-AZoospermia-Like (DAZL) gene has homologs required for germ cell development in many organisms. Recently, we showed that there are several common polymorphisms within the DAZL gene that are associated with age at ovarian failure/menopause and sperm count. METHODS: Here we sought to identify rare mutations in DAZL and examine their phenotypes in men and women. We sequenced the DAZL gene in 519 individuals; sequences spanned the entire coding region of the gene. RESULTS: We report the identification of four putative missense mutations in DAZL. Three individuals that were heterozygous for a DAZL mutation reported having children, while two individuals that were homozygous reported no children. These mutations were found only in infertile men and women. CONCLUSION: Given the strong data associating DAZL polymorphisms and deletions with fertility in humans and model organisms, we suggest that these mutations may be associated with age at menopause and/or sperm count and warrant further biochemical and genetic investigation

    Sustainable human resource management and job satisfaction— unlocking the power of organizational identification: A cross-cultural perspective from 54 countries

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    Sustainable human resource management is gaining importance in organizations due to its role in developing a sustainable work environment and well-being. This paper discusses the relationship between employee perceptions of sustainable human resource management and job satisfaction in 54 countries. We propose that sustainable HRM is positively associated with job satisfaction but that this relationship is moderated by employees’ identification with the organization and country-level individualism-collectivism. Thus, we suggest national culture functions as a second-level moderator of the relationship of sustainable HRM with organizational identification on job satisfaction. Findings from the multi-level analyses using data from 14,502 employees nested within 54 countries provided support for our hypotheses, namely that employee perceptions of sustainable HRM were positively associated with job satisfaction and that this relationship was more pronounced for employees with lower levels compared to higher levels of organizational identification in individualistic rather than collectivistic countries. These findings bear important implications for both theory and practice
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