Higher Education Society Preparedness to Emergencies and Disasters Activities and Responsibilities in Gümü?hane University

Yükseköğretim kurumlarında afet ve acil durum yönetiminin tüm evrelerinin uygulanabilmesi ve geliştirilebilmesi için, kapsamlı bir afet ve acil durum eylem planının oluşturulması gerekmektedir. Aynı zamanda kurumdaki tüm bireylerin afet ve acil durumlardaki görev ve sorumlulukları ile hazırlık ve bilgi düzeylerinin belirlenmesi amaçlanmıştır. Araştırmanın evrenini, Gümüşhane Üniversitesi Sağlık Bilimleri Fakültesinin personeli ve öğrencileri oluşturmaktadır. Afet ve acil durumlara yönelik hazırlıklı olma konusundaki algılarının değerlendirilmesi ve fakültenin afetlere hazırlık düzeyinin belirlenebilmesi amacıyla bir anket formu geliştirilmiş ve veriler bu anket formu aracılığıyla toplanmıştır. Çalışmamızda hazırlık ortalamasının 3,55±2,22 olduğu bulunmuştur. Personel katılımcıların hazırlık tutum ortalamaları ile, okul hazırlık puan ortalamaları arasında doğrusal bir ilişki bulunmuştur. Bilgi puan ortalamalarının diğer ortalamalar arasında istatistiksel olarak bir ilişkiye rastlanmamıştır.A comprehensive disaster and emergency action plan needs to be developed to be able to apply and develop all phases of disaster and emergency management in higher education institutions. At the same time, it was aimed to determine the level of preparation and knowledge of disaster and emergency situations and responsibilities and duties of all individuals in the institution. A questionnaire was developed to assess the perceptions of the administrative staff, academic staff and students of the Faculty of Health Sciences of Gümü?hane University, which constitute the researcher's universe, regarding the preparedness for disaster and emergency situations and to determine whether the faculty is ready for disasters. In our study, it was found that the average of the school preparations is 3.55 ± 2.22. As the average attitudes of the preparatory attitudes of the staff participants increase, the average of the school preparation scores increases. The relationship between participants' averages of 'Probability, Trust, Anxiety, Knowledge' scores was examined

Hepatocellular carcinoma: targeting of oncogenic signaling networks in TRAIL resistant cancer cells

Apoptotic response in hepatocellular carcinoma (HCC) cells is impaired because of interconnectivity of proteins into complexes and signaling networks that are highly divergent in time and space. TNF-related apoptosis-inducing ligand (TRAIL) has emerged as an attractive anticancer agent reported to selectively induce apoptosis in cancer cells. Although diametrically opposed roles of TRAIL are reported both as an inducer of apoptosis and regulator of metastasis, overwhelmingly accumulating experimental evidence highlighting apoptosis inducing activity of TRAIL is directing TRAIL into clinical trials. Insights from TRAIL mediated signaling in HCC research are catalyzing new lines of study that should not only explain molecular mechanisms of disease but also highlight emerging paradigms in restoration of TRAIL mediated apoptosis in resistant cancer cells. It is becoming progressively more understandable that phytochemicals derived from edible plants have shown potential in modelling their interactions with their target proteins. Rapidly accumulating in vitro and in-vivo evidence indicates that phytonutrients have anticancer activity in rodent models of hepatocellular carcinoma. In this review we bring to limelight how phytonutrients restore apoptosis in hepatocellular carcinoma cells by rebalancing pro-apoptotic and anti-apoptotic proteins. Evidence has started to emerge, that reveals how phytonutrients target pharmacologically intractable proteins to suppress cancer. Target-based small-molecule discovery has entered into the mainstream research in the pharmaceutical industry and a better comprehension of the genetics of patients will be essential for identification of responders and non-responders

The influence of CASP8 D302H gene variant in colorectal cancer risk and prognosis

Apoptosis is defined as programmed cell death, which regulates cellular functions and various physiological responses. Several studies reported that Caspase genes play important roles in the apoptosis and inflammation process. Caspase-8 (CASP8) is a member of the cysteine protease family and a key regulator gene in the induction of apoptosis. In present study, we aimed to investigate the possible associations between the CASP8; D302H (G>C) gene polymorphism and colorectal cancer risk and prognosis