387 research outputs found
Topological susceptibility in finite temperature QCD with physical domain-wall quarks
We perform hybrid Monte-Carlo (HMC) simulation of lattice QCD with
domain-wall quarks at the physical point, on the lattices, each with three lattice spacings. The lattice
spacings and the bare quark masses are determined on the lattices. The
resulting gauge ensembles provide a basis for studying finite temperature QCD
with domain-wall quarks at the physical point. In this paper, we
determine the topological susceptibility of the QCD vacuum for MeV. The topological charge of each gauge configuration is measured by
the clover charge in the Wilson flow at the same flow time in physical units,
and the topological susceptibility is determined for each
ensemble with lattice spacing and temperature . Using the topological
susceptibility of 15 gauge ensembles with three lattice spacings
and different temperatures in the range MeV, we extract the
topological susceptibility in the continuum limit. Moreover, a
detailed discussion on the reweighting method for domain-wall fermion is
presented.Comment: 36 pages, 5 figure
Decay Constants of Pseudoscalar -mesons in Lattice QCD with Domain-Wall Fermion
We present the first study of the masses and decay constants of the
pseudoscalar mesons in two flavors lattice QCD with domain-wall fermion.
The gauge ensembles are generated on the lattice with the
extent in the fifth dimension, and the plaquette gauge action at , for three sea-quark masses with corresponding pion masses in
the range MeV. We compute the point-to-point quark propagators, and
measure the time-correlation functions of the pseudoscalar and vector mesons.
The inverse lattice spacing is determined by the Wilson flow, while the strange
and the charm quark masses by the masses of the vector mesons
and respectively. Using heavy meson chiral perturbation theory
(HMChPT) to extrapolate to the physical pion mass, we obtain MeV and MeV.Comment: 15 pages, 3 figures. v2: the statistics of ensemble (A) with m_sea =
0.005 has been increased, more details on the systematic error, to appear in
Phys. Lett.
Paeonol Protects Memory after Ischemic Stroke via Inhibiting β-Secretase and Apoptosis
Poststroke dementia commonly occurs following stroke, with its pathogenesis related to β-amyloid production and apoptosis. The present study evaluate the effects of paeonol, one of the phenolic phytochemicals isolated from the Chinese herb Paeonia suffruticosa Andrews (MC), on protection from memory loss after ischemic stroke in the subacute stage. Rats were subjected to transient middle cerebral artery occlusion (tMCAo) with 10 min of ischemia. The data revealed that paeonol recovered the step-through latency in the retrieval test seven days after tMCAo, but did not improve the neurological deficit induced by tMCAo. Levels of Amyloid precursor protein (APP)- and beta-site APP cleaving enzyme (BACE; β-secretase)-immunoreactive
cells, and terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick end labeling (TUNEL)-positive cells decreased in the paeonol-administered group. Western blotting revealed decreased levels of Bax protein in mitochondria and apoptosis-inducing factor (AIF) in cytosol following paeonol treatment. In conclusion, we speculate that paeonol protected memory after ischemic stroke via reducing APP, BACE, and apoptosis. Supression the level of Bax and blocking the release of AIF into cytosol might participate in the anti-apoptosis provided by paeonol
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GenEpi: gene-based epistasis discovery using machine learning.
BackgroundGenome-wide association studies (GWAS) provide a powerful means to identify associations between genetic variants and phenotypes. However, GWAS techniques for detecting epistasis, the interactions between genetic variants associated with phenotypes, are still limited. We believe that developing an efficient and effective GWAS method to detect epistasis will be a key for discovering sophisticated pathogenesis, which is especially important for complex diseases such as Alzheimer's disease (AD).ResultsIn this regard, this study presents GenEpi, a computational package to uncover epistasis associated with phenotypes by the proposed machine learning approach. GenEpi identifies both within-gene and cross-gene epistasis through a two-stage modeling workflow. In both stages, GenEpi adopts two-element combinatorial encoding when producing features and constructs the prediction models by L1-regularized regression with stability selection. The simulated data showed that GenEpi outperforms other widely-used methods on detecting the ground-truth epistasis. As real data is concerned, this study uses AD as an example to reveal the capability of GenEpi in finding disease-related variants and variant interactions that show both biological meanings and predictive power.ConclusionsThe results on simulation data and AD demonstrated that GenEpi has the ability to detect the epistasis associated with phenotypes effectively and efficiently. The released package can be generalized to largely facilitate the studies of many complex diseases in the near future
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