Fine-needle aspiration accuracy in the diagnosis of primary epithelioid angiosarcoma of the adrenal gland: a case report and review of the literature

Primary epithelioid angiosarcoma of the adrenal gland is extremely rare. Only 37 cases have been reported in the scientific literature.Here we describe the case of a 55-year-old woman affected by metastatic angiosarcoma in the right adrenal gland, who died few days after the histological diagnosis made by fine-needle aspiration (FNA). This is the second case of primary epithelioid angiosarcoma diagnosed by FNA among scientific articles published in English in PubMed. Microscopically, the tumor showed a predominant epithelioid differentiation, thus making the diagnostic process more difficult than usual. Immunohistochemical examination revealed positive reactivity for cytokeratin, CD31, and CD34. The literature shows that epithelioid adrenal angiosarcoma has poor clinical outcome, especially when metastatic at presentation

The Role of Carbon Dioxide Laser Therapy in Penile Kaposi’s Sarcoma: A Case Series of Three HIV-Negative HHV-8-Positive Patients

Kaposi’s sarcoma (KS) is a rare tumor of vascular origin. It is quite common in HIV patients. It is rarely located on the glans penis, especially in HIV-negative patients (just some tens in the literature). Owing to the rarity of the disease, both the real impact on survival and the most suitable therapy are not known. However, in this 3-patient case series, carbon dioxide laser therapy was effective both for local control and survival. In fact, two late relapses but no disease-related death were recorded. Probably, KS in HIV-negative patients is a slowly progressive disease, not so aggressive as in HIV-positive patients. Laser therapy is easy, fast, and cheap, and may treat the disease radically. If these data are confirmed by further studies, in the foreseeable future, laser therapy may become the gold standard for treating HIV-negative patients affected by penile KS

Sindrome mediastinica da mieloblastoma quale manifestazione d'esordio di leucemia mieloide acuta

The authors report a case of acute myeloblastic leukemia which at the onset was characterized by a granuloblastic mediastinal tumor, without the appearance of a blastic population in the peripheral blood. The diagnosis was allowed by the cytological and cytochemical study of the pleural effusion. The autopsy confirmed the invasion of several organs by the myeloid malignant cells.The authors describe the clinical and histopathological characteristics of the disease. They point out that the histogenesis of this case and other similar ones reported in the literature remains obscure. The possibility is suggested that microenvironmental factors may have a critical role in facilitating the in situ proliferation of circulating blast cells with formation of solid tumor masses

Sinus histiocytosis with massive lymphadenopathy.

To date, the morphological aspects of sinus histiocytosis with massive lymphadenopathy (SHML) have been fully described. The disease is characterized by an enlargement of lymph nodes in which the sinuses are dilated and infiltrated by histiocytes, often phagocytosing lymphocytes. Even if the prognosis is usually benign and not requiring therapy, several fatal cases have been reported. The etiology is still obscure and the biology is not yet completely clear. Recent immunophenotypical studies suggest that histiocytes may belong to the T-zone associated histiocyte lineage. They may be cytologically homogeneous, but can express different antigenic patterns according to their stage of differentiation. Cytogenetic and molecular aspects of the disease have only been sporadically investigated. In order to better understand the pathogenesis of SHML, which seems to be a disorder lying in between the fields of infections, immunological disease and neoplasia, it is considered very useful to systematically employ a variety of immunophenotypical, cytogenetic and molecular techniques to study the disease, particularly in cases which are clinically atypical or with a more aggressive evolution

Immunoglobulin and T cell receptor beta chain gene rearrangements as lineage markers in human leukemias: a study of 78 cases. HAEMATOLOGICA 72, 391 397, 1987

In most cases, an excellent correlation was observed with diagnosis performed according to conventional criteria. Some cases of aberrant gene rearrangement, however, were found in acute myeloid leukemia, chronic lymphocytic leukemia and biphenotipic leukemia

I linfomi del centro germinativo: clinica, terapia e prognosi del linfoma maligno centroblastico-centrocitico.

Vengono riferiti i risultati di uno studio retrospettivo su 71 casi di linfoma maligno centroblastico-centrocitico osservati nei dipartimenti di Medicina interna e di Ematologia dell'Universit\ue0 di Modena nel periodo 1968-1979. 42 casi presentavano una architettura nodulare e 29 diffusa o nodulare-diffusa.L'et\ue0 d'esordio \ue8 risultata pi\uf9 elevata nelle forme diffuse (52,4 anni) rispetto a quelle nodulari (44,7 anni). Nella quasi totalit\ue0 dei pazienti erano presenti alla diagnosi linfoadenomegalie superficiali, in circa 1/3 localizzazioni extralinfatiche e in 27 pazienti sintomi B. L'87% dei LMcb/cc diffusi e il 63% dei nodulari gi\ue0 all'esordio erano in stadio III o IV.Sono riferiti i risultati delle principali indagini ematochimiche e strumentali. La terapia di induzione (mono o polichemioterapia e/o terapia radiante) ha determinato RC nel 67% delle forme nodulari e nel 37% delle forme diffuse.La sopravvivenza mediana attuariale di tutta la casistica \ue8 risultata di 91 mesi (103 mesi per le forme nodulari e 43 mesi per quelle diffuse). Al follow-up (31-12-81) dei 71 pazienti presi in esame 39 erano viventi (24 in RC e 15 in RP) e 32 deceduti (range 2-128)

Inflammatory myofibroblastic tumor of the bone marrow.

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Fine-needle aspiration accuracy in the diagnosis of primary epithelioid angiosarcoma of the adrenal gland: a case report and review of the literature

Primary epithelioid angiosarcoma of the adrenal gland is extremely rare. Only 37 cases have been reported in the scientific literature. Here we describe the case of a 55-year-old woman affected by metastatic angiosarcoma in the right adrenal gland, who died few days after the histological diagnosis made by fine-needle aspiration (FNA). This is the second case of primary epithelioid angiosarcoma diagnosed by FNA among scientific articles published in English in PubMed. Microscopically, the tumor showed a predominant epithelioid differentiation, thus making the diagnostic process more difficult than usual. Immunohistochemical examination revealed positive reactivity for cytokeratin, CD31, and CD34. The literature shows that epithelioid adrenal angiosarcoma has poor clinical outcome, especially when metastatic at presentation