Nephrocutaneous Fistula: An Unusual Nephrectomy Indication in Percutaneous Nephrolithotomy

Percutaneous nephrolithotomy (PNL) is recognized as the gold standard treatment method for stones larger than 2 cm due to its high success and acceptably low complication rates. The complications of PNL are well defined. Prolonged urinary leakage is one of them. In this study, a case of post-PNL urine leakage that was eventually treated with nephrectomy is discussed

Pulslu elektromanyetik alanın rejenere olan sıçan siyatik sinir demetinde potasyum kanallarına etkisinin sukroz - gap yöntemi ile incelenmesi

TEZ5074Tez (Doktora) -- Çukurova Üniversitesi, Adana, 2004.Kaynakça (s. 55-58) var.xvi, 58 s. ; 30 cm.

Lokal anesteziklerin tonik ve fazik etkilerinin sukroz-gap tekniği ile incelenmesi

TEZ2362Tez (Yüksek Lisans) -- Çukurova Üniversitesi, Adana, 1997.Kaynakça (s. 53-55) var.ix, 55 s. ; res. ; 30 cm.

Pulslu manyetik alanın ?-carrageenan’ın indüklediği akut pençe ödeminde antioksidan sistem üzerine etkisi

Purpose: ?-Carrageenan-induced (?-Carr) paw edema is a commonly used test for determining the acute phase of inflammation. In the present study, our aim was to investigate whether efficacy of pulsed magnetic field (PMF) on antioxidant enzymes levels is ?-Carr-induced rat paw edema. Material and Methods: The rats were whole-body exposed to PMF (1.5 mT intensity and 1, 10, 20, 40 Hz consecutive frequencies between Helmholtz coils) at the same hour in an hour in a day throughout 4 days at 3 hour later from injection of ?-Carr. Paw edema was determined at the end of fourth day by killing the rats, removed the paws at the ankle joint and paw mass (g) and paw thickness (mm) were was determined the right and left paw of rats. Then, the paw tissues were collected for the measurement of lipid peroxidation (Malondialdehyde; MDA) and antioxidant enzymatic activity levels (Catalase; CAT). Results: Carrageenan-induced right paw masses and paw thicknesses increased in compare to left paw of rats. While CAT levels were significantly decreased, MDA levels were increased in the carrageenan-induced rat right hind paw compare to control rat left paw.After exposed PMF to ?-Carr-induced right paw, while the CAT enzyme level decreased, the MDA enzyme level increased and there was no significant change in the weight and thickness of the right paw compare to unexposed groups. Conclusion: PMF increased edema in the rat paw and negatively affected antioxidant enzyme levels.Amaç: ?-Carrageenan ile indüklenen (?-Carr) pençe ödemi, inflamasyonun akut evresinin belirlenmesinde yaygın olarak kullanılan bir testtir. Bu çalışmanın amacı, ?-Carr'ın indüklediği sıçan pençe ödeminde pulslu manyetik alanın (PMF) antioksidan enzim düzeylerine etkinlğinin olup olmadığını araştırmaktı. Gereç ve Yöntem: Sıçanlar, ?-Carr injeksiyonundan 3 saat sonra 4 gün boyunca her gün günde 1 saat 1.5 mT şiddetinde ardışık 1, 10, 20, 40 Hz frekansları veren Helmholtz bobinlerinden oluşan pulslu manyetik alan etkisine maruz bırakıldılar. Dördüncü gün sıçanlar dekapite edildi ve pençelerindeki ödem değerlendirildi; Önce ayak bileği kesilerek pençe çıkarıldı, sağ ve sol pençe kütleleri (g) ve pençe kalınlıkları (mm) ölçüldü. Sonra pençelerde bulunan dokular lipit peroksidasyon (katalaz (CAT)) ve antioksidan enzim (malondialdehid (MDA)) aktivitelerini belirlemek için ayrıldı. Bulgular: Çalışmamızda sıçanların sol pençeleri , ?-Carr ile indüklenen sağ pençeler ile karşılaştırıldığında ?-Carr ile indüklenen sağ pençelerde kütlelerinin, pençe kalınlıklarının, CAT ve MDA enzim seviyelerinin arttığı görüldü. PMA uygulamasından sonra sağ pençelerin ağırlığı ve kalınlıklarında anlamlı değişiklik olmazken CAT enzimi azaldı, MDA enzim seviyesi ise arttı. Sonuç: PMF sıçan pençesinde ödemi arttırdı, antioksidan enzim seviyelerini de negatif olarak etkiledi

Pulsed magnetic field action on antioxidant system in ?-carrageenan induced acute paw edema

Amaç: ?-Carrageenan ile indüklenen (?-Carr) pençe ödemi, inflamasyonun akut evresinin belirlenmesinde yaygın olarak kullanılan bir testtir. Bu çalışmanın amacı, ?Carr'ın indüklediği sıçan pençe ödeminde pulslu manyetik alanın (PMF) antioksidan enzim düzeylerine etkinlğinin olup olmadığını araştırmaktı. Gereç ve Yöntem: Sıçanlar, ?-Carr injeksiyonundan 3 saat sonra 4 gün boyunca her gün günde 1 saat 1.5 mT şiddetinde ardışık 1, 10, 20, 40 Hz frekansları veren Helmholtz bobinlerinden oluşan pulslu manyetik alan etkisine maruz bırakıldılar. Dördüncü gün sıçanlar dekapite edildi ve pençelerindeki ödem değerlendirildi; Önce ayak bileği kesilerek pençe çıkarıldı, sağ ve sol pençe kütleleri (g) ve pençe kalınlıkları (mm) ölçüldü. Sonra pençelerde bulunan dokular lipit peroksidasyon (katalaz (CAT)) ve antioksidan enzim (malondialdehid (MDA)) aktivitelerini belirlemek için ayrıldı. Bulgular: Çalışmamızda sıçanların sol pençeleri , ?-Carr ile indüklenen sağ pençeler ile karşılaştırıldığında ?-Carr ile indüklenen kalınlıklarının, CAT ve MDA enzim seviyelerinin arttığı görüldü. PMA uygulamasından sonra sağ pençelerin ağırlığı ve kalınlıklarında anlamlı değişiklik olmazken CAT enzimi azaldı, MDA enzim seviyesi ise arttı. Sonuç: PMF sıçan pençesinde ödemi arttırdı, antioksidan enzim seviyelerini de negatif olarak etkiledi.Purpose: ?-Carrageenan-induced (?-Carr) paw edema is a commonly used test for determining the acute phase of inflammation. In the present study, our aim was to investigate whether efficacy of pulsed magnetic field (PMF) on antioxidant enzymes levels is ?-Carr-induced rat paw edema. Material and Methods: The rats were whole-body exposed to PMF (1.5 mT intensity and 1, 10, 20, 40 Hz consecutive frequencies between Helmholtz coils) at the same hour in an hour in a day throughout 4 days at 3 hour later from injection of ?-Carr. Paw edema was determined at the end of fourth day by killing the rats, removed the paws at the ankle joint and paw mass (g) and paw thickness (mm) were was determined the right and left paw of rats. Then, the paw tissues were collected for the measurement of lipid peroxidation (Malondialdehyde; MDA) and antioxidant enzymatic activity levels (Catalase; CAT). Results: Carrageenan-induced right paw masses and paw thicknesses increased in compare to left paw of rats. While CAT levels were significantly decreased, MDA levels were increased in the carrageenan-induced rat right hind paw compare to control rat left paw.After exposed PMF to ?Carr-induced right paw, while the CAT enzyme level decreased, the MDA enzyme level increased and there was no significant change in the weight and thickness of the right paw compare to unexposed groups. Conclusion: PMF increased edema in the rat paw and negatively affected antioxidant enzyme levels

Pulsed magnetic field action on antioxidant system in lambda-carrageenan induced acute paw edema

WOS: 000414861000004Purpose: lambda-Carrageenan-induced (lambda-Carr) paw edema is a commonly used test for determining the acute phase of inflammation. In the present study, our aim was to investigate whether efficacy of pulsed magnetic field (PMF) on antioxidant enzymes levels is lambda-Carr-induced rat paw edema. Material and Methods: The rats were whole-body exposed to PMF (1.5 mT intensity and 1, 10, 20, 40 Hz consecutive frequencies between Helmholtz coils) at the same hour in an hour in a day throughout 4 days at 3 hour later from injection of lambda-Carr. Paw edema was determined at the end of fourth day by killing the rats, removed the paws at the ankle joint and paw mass (g) and paw thickness (mm) were was determined the right and left paw of rats. Then, the paw tissues were collected for the measurement of lipid peroxidation (Malondialdehyde; MDA) and antioxidant enzymatic activity levels (Catalase; CAT). Results: Carrageenan-induced right paw masses and paw thicknesses increased in compare to left paw of rats. While CAT levels were significantly decreased, MDA levels were increased in the carrageenan-induced rat right hind paw compare to control rat left paw. After exposed PMF to lambda-Carr- induced right paw, while the CAT enzyme level decreased, the MDA enzyme level increased and there was no significant change in the weight and thickness of the right paw compare to unexposed groups. Conclusion: PMF increased edema in the rat paw and negatively affected antioxidant enzyme levels

The role of N-methyl D-aspartate receptors on pain transmission

Amaç : Yapılan deneysel çalışmalar, NMDA (N-methyl-D-aspartate) reseptörlerinin ağrı tedavilerine yönelik kullanılan ilaçların etki mekanizmalarında en önemli etken mekanizmalardan biri olabileceğini gösterilmiştir. Spinal kord dorsal boynuzda yer alan NMDA reseptörleri santral sensitizasyon için esastır, periferik yaralanmada santral sensitizasyon ağrının iletilmesinde rol oynar. Bu çalışmada NMDA reseptör agonisti ve antagonisti kullanarak periferal NMDA reseptörlerinin ağrı bilgisinin iletilmesindeki katkılarına yönelik yeni bilgilere ulaşmak amaçlandı. Gereç-Yöntem : Çalışmada, sıçanlara intraplantar olarak uygulanan N metil aspartik asit (NMDA) ve antagonisti olan MK-801’nin doz ve zamana bağlı olarak sıçanların geri çekme latansına etkileri termal plantar test yöntemi kullanılarak araştırıldı. Bulgular : MK-801 doza bağlı olarak termal anti-nosiseptif etkiler oluştururken, NMDA termal latansta azalma meydana getirerek hiperaljezinin ortaya çıkmasına neden oldu. Sonuç : Periferal NMDA reseptörlerinin ağrı bilgisinin iletilmesinde dominant bir rol oynayabileceğini göstermektedir.Aim : In the experimental studies, NMDA (N-methyl-D-aspartate) receptors play important role in the mechanism of action among the drugs used for the treatment of pain. The NMDA receptors in the dorsal horn of spinal cord is essential for central sensitization and the central facilitation of pain transmission produced by peripheral injury. The aim of this study was to evaluate the contributions of peripheral NMDA receptor agonist and antagonists in peripheral pain transmission. Material-Method : In the present study, N methyl aspartic acid (NMDA) and antagonist ( MK-801) were administered intraplantarily to investigate withdrawal effects, the dose and time dependent latency using thermal plantar test method in rats. Results : MK-801 caused dose-dependent thermal anti-nociceptive effects, whereas NMDA led to reduction in the thermal nociceptive latency and hyperalgesia. Conclusion : Peripheral NMDA receptors may play a dominant role in the transmission of pain information

The Role of N-Methyl D-Aspartate Receptors on Pain Transmission

Aim : In the experimental studies, NMDA (N-methyl-D-aspartate) receptors play important role in the mechanism of action among the drugs used for the treatment of pain. The NMDA receptors in the dorsal horn of spinal cord is essential for central sensitization and the central facilitation of pain transmission produced by peripheral injury. The aim of this study was to evaluate the contributions of peripheral NMDA receptor agonist and antagonists in peripheral pain transmission. Material-Method : In the present study, N methyl aspartic acid (NMDA) and antagonist ( MK-801) were administered intraplantarily to investigate withdrawal effects, the dose and time dependent latency using thermal plantar test method in rats. Results : MK-801 caused dose-dependent thermal anti-nociceptive effects, whereas NMDA led to reduction in the thermal nociceptive latency and hyperalgesia. Conclusion : Peripheral NMDA receptors may play a dominant role in the transmission of pain information. [Cukurova Med J 2012; 37(1): 9-16

Pain Control and Its Relationship with Histopathological Outcome in TRUS-Guided Prostate Needle Biopsy: A Prospective Non-Randomized Trial

Objective Transrectal ultrasound-guided prostate biopsy (TRUS-Bx) is a standard diagnostic modality for detecting prostate cancer (PCa). Pain during biopsy is the most important problem that still needs a solution. The purpose of this study was to compare 3 pain control techniques and to investigate the relationship between the level of pain and histopathological findings. Materials and Methods 139 patients underwent prostate biopsy utilizing 3 analgesic techniques; 1- using lidocain gel (group 1), 2- pethidine+diazepam (group 2) and 3- periprostatic nerve block (group 3). Pain level, the tolerability and repetition of the procedure were questioned. The pathological findings were recorded. Results There was a statistically significant difference between group 1 and the others with regard to tolerability and repeating the procedure. The pain score during biopsy in group 1 was greater than in the other groups and those in group 2 was higher than in group 3. The mean pain score during probe insertion in group 2 was lower than in groups 1 and 3. The mean pain score taken during the biopsy was higher than that during probe insertion in group 2. However, the mean pain score during probeinsertion in group 3 was not different from that in group 1. There was no significant difference in pathological results between group 1 and groups 2 and 3. Pain scores in patients with chronic prostatitis were statistically higher than those in patients with benign prostatic hyperplasia (BPH) and Pca in groups 2 and 3 (p<0.05). Conclusion Periprostatic nerve block is superior to the others. However, it is not better than pethidine plus diazepam during rectal probe insertion. In the presence of chronic prostatitis, pain scores can increase regardless of the pain control method