Herbal remedies against Huntington's disease: Preclinical evidences and future directions

Herbal medicines, or phytochemicals can treat various neurological disorders, and is actually preferred over synthetic drugs due to their lower cost, negligible side effects, easy availability and therapeutic efficiency. This article lists a total of 13 plant extracts, 27 plant derived natural compounds and 3 herbal formulations that were found to therapeutically cure Huntington's Disease, mainly by eliminating the toxic mHtt proteins(the product of the mutant gene responsible for HD). The various plant compounds, fractions, extracts and herbal formulations were summarized from popular scientific search engines and then analyzed on the basis of their source and bioactivity. To understand the behavioral, biochemical and morphological changes caused by HD, experimental models like 3-NP and transgenic animal models like rats, mice, Drosophila and Caenorhaditis elegans were used. Plants such as Bacopa monnieri, Celastrus paniculatus, Centella asiatica, Gastrodia elata, Panax ginseng, and Withania somnifera are some examples that possess anti-HD properties. Some examples of promising plant compounds possessing similar properties are fisetin, curcumin, hesperidin, trehalose, onjisaponin B, sesamol, resveratrol, kaempferol and melatonin. Herbal formulations discussed here are B307, CLMT and YGS. These are proved to be more beneficial than single herbs because they can regulate more targets. However, detailed study and further research should be conducted to determine the therapeutic efficacy of herbal extracts and compounds in HD models. © 2022 Elsevier Inc. All rights reserved

Abstracts of National Conference on Research and Developments in Material Processing, Modelling and Characterization 2020

This book presents the abstracts of the papers presented to the Online National Conference on Research and Developments in Material Processing, Modelling and Characterization 2020 (RDMPMC-2020) held on 26th and 27th August 2020 organized by the Department of Metallurgical and Materials Science in Association with the Department of Production and Industrial Engineering, National Institute of Technology Jamshedpur, Jharkhand, India. Conference Title: National Conference on Research and Developments in Material Processing, Modelling and Characterization 2020Conference Acronym: RDMPMC-2020Conference Date: 26–27 August 2020Conference Location: Online (Virtual Mode)Conference Organizer: Department of Metallurgical and Materials Engineering, National Institute of Technology JamshedpurCo-organizer: Department of Production and Industrial Engineering, National Institute of Technology Jamshedpur, Jharkhand, IndiaConference Sponsor: TEQIP-