In silico study of PEI-PEG-squalene-dsDNA polyplex formation: the delicate role of the PEG length in the binding of PEI to DNA

Using a two step simulation protocol the atomistic interactions between PEG and b-PEI and the effect of these interactions on DNA binding were determined

Acne inversa (Hurley clinical stage II ): case report

We present a case of acne inversa Hurley clinical stage II, to a 28 year-old patient non-obese, smoker, with a long history of firm nodules, large abscesses and sinous tracts, small scars, distributed in the axillary, groin, perianal and infraumbilical areas, associated with lesions on the face. Any therapeutic schemas ( antibiotics, Isotretinoin orally, Dapsone, UVB,cryotherapy) was unsuccesfully and we sent the patient to Surgery Department for wide excisions

Hand, Foot and Mouth disease in northeastern part of Romania in 2012

Hand-foot-mouth disease (HFMD) is an acute viral infection that occurs usually among children in summer. This paper reports a high incidence of HFMD in children and adults, occurred in summer-autumn 2012 in the northeastern part of Romania. We present a few cases with some atypical clinical manifestations

Ulcerated Hemangioma - Surveillance Only

Infantile hemangiomas are reported in 10-12% of children less than 1 year of age, with ulceration in about 5-13% of cases. Little is known about the mechanism of this disease and explanations are still being looked for

Yellow palms and feet in a child

The yellowish discoloration of the palms and skin is reported under different terms: xanthodermia, hypercarotenemia, carotenemia, carotenodermia. Yellow discoloration of the skin may be associated with carotenemia, hypothyroidism, diabetes mellitus, hyperlipoproteinemia, liver disease, and renal disease, meaning that carotenemia is not synonym with yellow skin, but rather one of the cause. We presented an 8 year-old boy with a yellow discoloration of the palms and soles, observed by the mother 3 weeks prior to medical examination. The discoloration was uniformly distributed, rather symmetrically, no nails changes, just a mild xerosis palmaris on the right hypotenar area. In lab investigations only were: hypercholesterolemia. The final diagnosis was xanthodermia in context of hyperlypoproteinemia type II A