The significance of immunohistochemical markers in the assessment of the oral mucosa

Leukoplakia - the most common lesion of the oral mucosa. Early methods of diagnosis of this disease are the key to successful treatment. With the aim of improving the quality of the diagnostic features of verrucous leukoplakia, immunohistochemical examination was conducted of the buccal mucosa biopsy specimens that were taken from 12 patients who had applied for the purpose of routine inspection in the period 2017-2019 biennium. We present the results of the immunohistochemical method of research, allowing to timely determine the pathological transformation of the epithelial cells of the mucous membrane of the cheeks in the pathological focus.Лейкоплакия - наиболее распространенное поражение слизистой оболочки рта. Ранние методы диагностики этого заболевания является залогом успешного лечения. С целью повышения качества диагностических особенностей веррукозной лейкоплакии, было проведено иммуногистохимическое исследование биоптатов слизистой оболочки щек взятых у 12 пациентов, которые обратились с целью профилактического осмотра в период 2017-2019 гг. Нами представлены результативные данные иммуногистохимического метода исследования, позволяющие своевременно определить патологическую трансформацию клеток эпителия слизистой оболочки щек в области патологического очага

Comorbid Complicated Course of Vegetative Diabetic Polyneuropathy. Clinical Case. Multidisciplinary Approach in Treatment

Diabetic polyneuropathy is the most difficult to diagnose manifestation of diabetes mellitus. It affects many organs and systems and exacerbates complications of both an infectious and non-infectious nature. Currently, tuberculosis remains one of the socially significant pathologies in the modern medicine. Extrapulmonary form (for example, liver tuberculosis) is one of the most difficult to diagnose forms of this pathology. Mortality in the presence of an asymptomatic course is up to 40% in the population of patients with liver tuberculosis. This article provides an example of diagnostic analytics, supervision, and combination treatment with a multidisciplinary approach on the example of a specific clinical case from practice

INTEGRATION OF INPUT - OUTPUT APPROACH INTO AGENT-BASED MODELING. PART 1. METHODOLOGICAL PRINCIPLES

The article presents a comparison of the Agent-Based Multiregional Input-Output Model (ABMIOM) of the Russian economy and a small-size version of the Optimization Multiregional Input-Output Model (OMIOM) from the per-spective of their possible integration for spatial economic research. These models share many similar features, technically and conceptually. The two models regard the economy as a complex system of interdependent compo-nents; both have the same spatial and sectoral structure, similar production technologies. Both allow to perform a structural analysis of processes taking place in the economy in terms of industries and territories. The former is a simulation model, the latter is a linear optimization model; their major differ-ences relate to the methods of modeling the market and price mechanisms and of representing the space. We propose to use a spatial input-output model based on the real data as the source of disaggregated information at the stage of initialization of agent-based models, which opens opportunities of gradual turning them into an experimentation area for the real economy, rather than an instrument for an analysis of an artificial economy

INTEGRATION OF INPUT - OUTPUT APPROACH INTO AGENT-BASED MODELING. PART 2. INTERREGIONAL ANALYSIS IN AN ARTIFICIAL ECONOMY

The article demonstrates the possibilities of spatial analysis provided by the Agent-Based Multiregional Input - Output Model (ABMIOM) of the Russian economy. The basic hypothesis of the ABMIOM is that agents’ decisions at the microeconomic level lead to spatial changes at the macro level. Confirmation of this hypothesis requires experimental calculations with changes in various parameters that influence agents’ decisions (such as prices, taxes, tariffs, etc.). Analyzing the results of these calculations requires moving from microeconomic data to the macro level. The paper proposes a method for the structural analysis of the model simulation results using input-output tables. The method involves statistical aggregation of calculation results, construction of regional, national and interregional input-output tables and structural analysis of the obtained tables including calculation of regional Leontief multipliers. The method proposed is used to study the influence of the level of transport costs on the geographical structure of trade flows. The results of the experiments confirmed that with the increase of transportation costs economic agents prefer to interact with nearest agents, which leads to a decreased interregional commodity exchange and to economic «insulation» of the regions

A comprehensive approach to the in vitro and in vivo study of a preparation containing etidronate of lanthanide and calcium ions

© 2019 Russian Ilizarov Scientific Center for Restorative Traumatology and Orthopaedics. The search for new more effective techniques to repair bone fractures and defects is an urgent task of healthcare. Objective To explore the efficacy of a preparation containing etidronates of lanthanide and calcium ions in regenerative repair of bone defects. Material and methods The osteoblastic MC3T3-E1 and the osteoclastic RAW 264.7 cell lines were used in in vitro experiments at the first stage of the research. The agent was postoperatively injected in a bone defect of 36 rabbits on days 3 and 5 to assess the preparation's effect on regenerative repair of small defects with diameter of 2.5 mm. Radiometric and reactive morphological characteristics of bone tissue were evaluated at the fracture site at the beginning, middle and end of experiment. Results The above preparation was found to enhance osteogenic differentiation and stimulate accumulation of intracellular calcium in MC3T3 E1 cells. However, the preparation was not shown to inhibit RANKL-induced osteoclast differentiation in vitro. Histological and computed tomography findings demonstrated statistically significant differences between control and experimental animals (p < 0.01) and indicated to the preparation's effect of promoting regenerative repair of small bone defects. Conclusion The series was the first to show the effect of the preparation containing etidronates of lanthanide and calcium ions as stimulating osteoblast activity in vitro and promoting early regenerative repair of small bone defects

A comprehensive approach to the in vitro and in vivo study of a preparation containing etidronate of lanthanide and calcium ions

© 2019 Russian Ilizarov Scientific Center for Restorative Traumatology and Orthopaedics. The search for new more effective techniques to repair bone fractures and defects is an urgent task of healthcare. Objective To explore the efficacy of a preparation containing etidronates of lanthanide and calcium ions in regenerative repair of bone defects. Material and methods The osteoblastic MC3T3-E1 and the osteoclastic RAW 264.7 cell lines were used in in vitro experiments at the first stage of the research. The agent was postoperatively injected in a bone defect of 36 rabbits on days 3 and 5 to assess the preparation's effect on regenerative repair of small defects with diameter of 2.5 mm. Radiometric and reactive morphological characteristics of bone tissue were evaluated at the fracture site at the beginning, middle and end of experiment. Results The above preparation was found to enhance osteogenic differentiation and stimulate accumulation of intracellular calcium in MC3T3 E1 cells. However, the preparation was not shown to inhibit RANKL-induced osteoclast differentiation in vitro. Histological and computed tomography findings demonstrated statistically significant differences between control and experimental animals (p < 0.01) and indicated to the preparation's effect of promoting regenerative repair of small bone defects. Conclusion The series was the first to show the effect of the preparation containing etidronates of lanthanide and calcium ions as stimulating osteoblast activity in vitro and promoting early regenerative repair of small bone defects

Polarization control in spin-transparent hadron colliders by weak-field navigators involving lattice enhancement effect

Hadron polarization control schemes for Spin Transparent (ST) synchrotrons are analyzed. The spin dynamics and beam polarization in such synchrotrons are controlled by spin navigators (SN) which are special small insertions of weak magnetic fields. An SN stabilizes the beam polarization and allows for setting any desirable spin orientation at an interaction point in the operational regime, including a frequent spin flip. We present a general approach to design of SNs. We distinguish different types of SNs, namely, those not causing closed orbit perturbation as well as those producing local and global orbit distortions. In the second case, the concept of the spin response function in an ST synchrotron is applied and expanded to reveal the effect of the SN strength enhancement by magnetic lattice of the synchrotron. We provide conceptual schemes for SN designs using longitudinal and transverse magnetic fields allowing for polarization control at low as well as high energies. We also develop the ST concept for ultra-high energies. This development may enable and stimulate interest in polarized beam experiments in possible polarized collider projects such as Large Hadron Collider (LHC), Future Circular Collider (FCC) and Super Proton Proton Collider (SPPC)