ЭКСПЕРИМЕНТАЛЬНОЕ И КЛИНИЧЕСКОЕ ОБОСНОВАНИЕ ПРИМЕНЕНИЯ ЭЛЕКТРОМАГНИТНЫХ ВОЛН ТЕРАГЕРЦЕВОГО ДИАПАЗОНА НА ЧАСТОТАХ ИЗЛУЧЕНИЯ И ПОГЛОЩЕНИЯ ОКСИДА АЗОТА И КИСЛОРОДА ПРИ РАЗЛИЧНЫХ ФОРМАХ ПАТОЛОГИИ

Most of the abiotic environmental factors are electromagnetic in nature. Electromagnetic radiation from various artificial sources exerts a significant inf luence on living systems. It poses a problem of targeted application of electromagnetic waves in health care, ever yday life, and industr y. Recently, a fundamentally new direction in medicine has emerged: the use of low-power terahertz electromagnetic waves at the frequency of oscillation of active cellular metabolites (nitrogen oxide, molecular oxygen, etc.) for disease treatment and prevention. It has been demonstrated that if there is a match in frequency bet ween the emitted electromagnetic wave and the natural oscillation of the molecule, absorption occurs and this alters the amplitude of the molecular oscillation and modifies involvement of the molecule in the metabolic process. This fact is of great interest for biomedical technologies because cellular metabolites may significantly affect regional circulation, microcirculation, and blood rheology; prevent intravascular coagulation; provide anti-inf lammator y and analgesic effects; limit excessive lipid peroxidation and potentiate the antioxidant mechanism; activate cellular anti-stress mechanisms. Today,  terahertz electromagnetic radiation at the frequency of oscillation of nitric oxide, a universal cellular regulator y molecule, has been shown to be beneficial in the treatment of cardiovascular diseases, burns, polyneuropathy, regional pain syndrome, etc. This review summarizes clinical and experimental data on implementation of terahertz electromagnetic waves in medicine and presents our current understanding of the mechanisms of action of terahertz electromagnetic waves at the frequency of oscillation of active cellular metabolites on a living system at the molecular, cellular, tissue, and organ levels of organization.Большинство абиотических факторов внешней среды, играющих существенную роль в процессах жизнедеятельности человека, имеют электромагнитную природу. В биосфере электромагнитные колебания различных частот обладают разными информационными и энергетическими свойствами. Искусственные источники электромагнитных колебаний способны оказывать воздействие на живые системы. Это ставит задачу поиска возможностей их целенаправленного применения в клинической практике,  быту и промышленности. Электромагнитные волны крайне высокой частоты уже успешно применяют в комплексном лечении различных социально значимых заболеваний человека. В последние годы экспериментально и теоретически обосновано принципиально новое направление в медицине и биологии — применение электромагнитного излучения терагерцевого диапазона малой мощности с той же частотой молекулярного спектра поглощения и излучения, что и у биологически активных молекул — естественных регуляторов функций организма. Известно, что отдельные биологически активные молекулы, такие как оксид азота и кислород, обладают способностью изменять уровень регионарного кровообращения и микроциркуляции, реологические свойства крови, в том числе при различных заболеваниях; препятствовать внутрисосудистому свертыванию крови и тромбозу; оказывать противовоспалительное и обезболивающее действие; ограничивать избыточную интенсивность свободнорадикального перекисного окисления  липидов  и  активировать  факторы с антиоксидантной активностью;  обеспечивать стресслимитирующий  эффект.  Терагерцевые  волны  с  частотой  колебаний  молекулярного  спектра поглощения и излучения оксида азота используются в практическом здравоохранении (при лечении заболеваний сердечно-сосудистой системы, ожогов, полинейропатий, регионарного болевого синдрома и др.) с хорошим терапевтическим эффектом. В настоящее время интенсивно изучаются эффекты действия электромагнитных волн терагерцевого диапазона с частотами электромагнитных колебаний биологически активных молекул на живые системы, а также механизмы реализации этих эффектов на молекулярном, клеточном и органно-тканевом уровнях организации биосистем. Именно этим проблемам посвящен настоящий обзор литературных данных последних 15 лет

Transport and magnetotransport properties of cold-pressed CrO2_2 powder, prepared by hydrothermal synthesis

Submicron powder of CrO$_2$ was prepared by hydrothermal synthesis method from chromium trioxide. Particles obtained were of rounded form with mean diameter about 120 nm. The powder (stabilized with thin surface layer of \beta-CrOOH) has been characterized by structural, X-ray and magnetic measurements. The powder (with Curie temperature about 385 K) was cold-pressed and its transport and magnetotransport properties have been measured in the temperature range 4--450 K in magnetic field up to 1.6 T. The samples studied is characterized by non-metallic temperature behavior of resistance and large negative magnetoresistance (MR) in low temperature range. At T=5 K the MR magnitude has been -17% at H=0.3 T and -20% at H=1.4 T. Its magnitude decreased fast with increase in temperature reducing to 0.3% and less for T>200 K. It is shown that this MR behavior is inherent for a system of magnetic grains with spin-dependent intergrain tunnelling. Some peculiarities of MR behavior in low-temperature range (below 40 K) can be associated with percolating character of tunnelling conductivity of this granular system under conditions of availability of only few conducting current paths through the sample.Comment: 21 pages (including 9 separate figures), submitted to J. of Alloys and Compound

Effect of Anesthesia on Postoperative Pain in Patients after Septoplasty

Abstract: The aim of the study was to assess acute pain syndrome in patients after septoplasty using different tactics of general anesthesia. All patients received local anesthesia with 2% procaine solution. In group 1 (95 patients), premedication with 2% promedol solution and 60 mg of ketorolac in the evening was used; group 2 (72 patients) was administered with fentanyl, propofol, cisatracuria besylate, tranexamic acid, atropine, and metoclopramide; and group 3 (89 patients) received atracuria besylate, sodium thiopental, nitrous oxide, and halothane. In groups 2 and 3, 100 mg of ketoprofen was administered intramuscularly in the evening on the day of surgery. Anterior tamponade was performed with parolon tampons in glove rubber. In groups 1 and 2, the tamponade was removed on day 2, and in group 3 it was removed 1 day after surgery. Pain syndrome was assessed on 1, 3, and 6 h and on days 1 and 2 after surgery. It was found that the scheme of anesthesia in group 2 is the most preferable, and the nasal tamponade must be removed on the 2nd day after the surgery. © 2022, Pleiades Publishing, Ltd

COVID-19 VIRUS-POSITIVE PATIENTS AFTER LARINGECTOMY: TREATMENT IN A HOSPITAL

The coronavirus pandemic is spreading rapidly around the world. The health systems of all countries faced extraordinary problems in terms of the creation and distribution of medical resources, including the re-equipment and creation of new hospital beds, and the provision of personal protective equipment. The patients who undergo a laryngectomy are a special category. Given the fact that during the operation they have a separation of the upper and lower respiratory tract, in the context of the COVID-19 pandemic, such patients require special attention from oncologists and otorhinolaryngologists. Purpose of the study is to review the characteristics of patient management after a laryngectomy in a COVID-19 pandemic. Laryngectomy patients represent a unique contingent in conditions of coronavirus infection SARS-COV-2, it is advisable to focus on providing them with protective equipment. This will significantly reduce the risk of infection with their virus, which can be a deadly threat to them. Infected patients during an epidemic represent a potential source of infection for medical personnel, which requires special protective measures. All procedures associated with the replacement of the prosthesis, endoscopic manipulations, it is advisable to postpone until the normalization of the epidemiological situation. If carrying out such operations is vital, then they should be carried out, observing all necessary precautions for both the patient and medical personnel

The nonlinear resilient functions from binary block codes

Рассматриваются методы построения нелинейных узлов замен симметричных криптографических алгоритмов, исследуются показатели и критерии их эффективности. Рассматривается метод построения нелинейных эластичных функций из двоичных линейных блочных кодов, анализируется перспективность данного метода для получения функций с улучшенными показателями стойкости. Исследуются свойства синтезируемых булевых функций по различным показателям стойкости. Оценивается достигаемая нелинейность и эластичность для функций, полученных из различных классов линейных блоковых кодов, проводятся сравнения с другими методами синтеза и верхними теоретическими границами для сбалансированных криптографических функций.Розглядаються методи побудови нелінійних вузлів замін симетричних криптографічних алгоритмів, досліджуються показники критерії їх ефективності. Розглядається метод побудови нелінійних еластичних функції з двійкових лінійних блокових кодів, аналізується перспективність даного методу для отримання функцій з поліпшеними показниками стійкості. Досліджуються властивості синтезованих булевих функцій за різними показниками стійкості. Оцінюється нелінійність, що досягається, та еластичність для функцій, отриманих з різних класів лінійних блокових кодів, проводяться порівняння з іншими методами синтезу й верхніми теоретичними межами для збалансованих криптографічних функцій.Methods of creation of nonlinear nodes of changeovers of the symmetric cryptographic algorithms are considered, indexes and criteria of their efficiency are researched. The method of creation of nonlinear resilient functions from the binary linear block codes is considered, perspectivity of the given method for obtaining of functions with the improved indexes of security is analyzed. Properties of synthesizable Boolean functions on various indexes of security are researched. Nonlinearity and resilient for the functions which are received from various classes of the linear block codes is estimated. Make comparisons with other methods of synthesis and the upper theoretical boundaries for the balanced cryptography functions

New lateral flow immunoassay for on-site detection of Erwinia amylovora and its application on various organs of infected plants

Erwinia amylovora causes a quarantine disease called fire blight that affects most plants from the Rosaceae family. An efficient and rapid disease diagnosis tool is needed to prevent the spread of the pathogen. The main objective of this study was to develop a lateral flow immunoassay (LFIA) to detect E. amylovora and compare different organs of plants for optimization of LFIA testing. A total of 11 strains of E. amylovora and related species were tested for specificity of the developed LFIA. The detection limit of E. amylovora was equal to 4 × 105 CFU mL−1 in plant extracts. LFIA showed high specificity and did not demonstrate positive results with non-related species. Meanwhile, LFIA's effectiveness was confirmed through testing artificially infected leaf samples of apple, pear, and black raspberry. Reliable results were obtained 10 min after the start of LFIA for all testing strains. Different plant organs (121 samples) comprising apple, pear, hawthorn, quince, blackthorn, and cherry from naturally infected areas with symptoms of varying severity were tested. The LFIA was performed using samples from leaves, twigs, flowers, fruitlets, and bacterial ooze; for confirmation commercial kits based on fluorescent amplification–based specific hybridization PCR were used. Using several samples from one plant (cluster) significantly increased the accuracy of infected plant detection, the overlap of LFIA and PCR were equal to 70.2% for individual samples and 93.5% for clusters. Observed recovery of E. amylovora for different organs differed by up to 20%. We found out that using vascular tissues was better than using leaf extracts. This result demonstrates that LFIA's effectiveness improved when more appropriate samples were used. © 2021 Elsevier Lt

ASSESSMENT OF THE EFFECT OF ANESTHESIA METHODS ON HRV AND PAIN SYNDROME AFTER SEPTOPLASTY

Aims: to evaluate various methods of anesthesia during septoplasty for changes in heart rate variability (HRV) and acute pain syndrome in the early postoperative period. Patients and methods. All patients received local anesthesia with 2% procaine solution. In group 1(105 people) premedication was used with 2% promedol solution and 60 mg of ketorolac in the evening, in group 2 (108 people) -fentanyl, propofol, cisatracuria besylate, tranexamic acid, atropine and metoclopramide, in group 3 (78 people) - atracuria besylate, sodium thiopental, nitrous oxide and halothane. In groups 2 and 3, 100 mg of ketoprofen was administered intramuscularly in the evening on the day of surgery. The frequency domain of HRV was estimated per day. Pain was assessed using a visual analogue scale (VAS). Results. ULF and LF were significantly higher in groups 2 and 3 than in the local anesthetic group. VLF in the second group was significantly lower than in groups 1 and 3. Groups 2 and 3 had low HF. The VHF of group 2 was significantly lower than in groups 1 and 3, which also differed from each other - the VHF values in group 1 were higher than in group 2. Total power in group 2 was significantly lower than in groups 1 and 3. Pain syndrome was less pronounced in group 2. Conclusion. The following scheme may be less stressful when performing septopalstics for general anesthesia: fentanyl, propofol, cisatracuria besylate, tranexamic acid, atropine and metoclopramide