Ring-size-selective construction of fluorine-containing carbocycles via intramolecular iodoarylation of 1,1-difluoro-1-alkenes

1,1-Difluoro-1-alkenes bearing a biaryl-2-yl group effectively underwent site-selective intramolecular iodoarylation by the appropriate cationic iodine species. Iodoarylation of 2-(2-aryl-3,3-difluoroallyl)biaryls proceeded via regioselective carbon–carbon bond formation at the carbon atoms in β-position to the fluorine substituents, thereby constructing dibenzo-fused six-membered carbocycles bearing a difluoroiodomethyl group. In contrast, 2-(3,3-difluoroallyl)biaryls underwent a similar cyclization at the α-carbon atoms to afford ring-difluorinated seven-membered carbocycles

Influence of microstructure on fatigue property of ultra high-strength steels

Ultra-high-strength steels (with tensile strength higher than 980 MPa) are widely used in automobile manufacturing owing to their lightweight that contributes to fuel efficiency. The fatigue strength of ultra-high-strength steels with a notch tends to decrease, which is known as the effect of notch sensitivity. In this study, 4-point bending fatigue tests were performed to examine the fatigue strength and notch sensitivity of four steels; namely 590 MPa class steel, 980 MPa class martensitic steel, 980 MPa class bainitic steel, and 980 MPa class precipitation hardening steel plates with three different stress concentration factors. The results indicate that the fatigue strength and notch sensitivity of 980 MPa class steel specimens were higher than those of 590 MPa class steel specimens. The notch sensitivities of tested plate specimens were lower than those reported for cylindrical specimens of bainitic ultra-high-strength steels. Fatigue crack observation revealed that the cracks initiated in 590 MPa class steel, 980 MPa class bainitic, and martensitic steel propagated southward from the lowest bottom of notch. Although similar initial crack propagation pattern was detected in precipitation hardening steel, the crack changed direction when it reached the central part of the specimen

舌の厚みとその臨床的意義

Background: The tongue occupies most of the space in the oral cavity and it plays an important role in oral functions such as mastication, swallowing and articulation. The tongue continues to move from the time of intake to swallowing, particularly during masticating. A method for evaluating tongue thickness at rest by ultrasonography has been proposed; however, the association between tongue thickness and various oral functions remains unclear. Objective: The purpose of this study was to investigate the relation between tongue thickness and oral functions, and to clarify the clinical significance of tongue thickness measurements in oral function maintenance. Materials and Methods: Elderly outpatients were serially screened for enrollment and a total of 106 subjects (men, 54; women, 52; mean age, 75.2±6.5 years) were selected. Age, body mass index, and functional teeth number including implant and pontic of fixed partial denture number were recorded as the basic attributes. Tongue thickness, tongue pressure, tongue thrust pressure and tongue motor function were measured as tongue assessments. Cheek pressure, oral moisture and occlusal force were measured as other oral functions. Results: Subjects with thick tongue tended to have higher BMI, stronger muscle strengths and lower diadochokinesis. Diadochokinesis of/ka/, cheek pressure and functional teeth number were extracted as the independent factors affecting tongue thickness. Conclusion: Tongue thickness does not necessarily reflect oral functions in healthy elderly people except for a negative association between tongue thickness and oral diadochokinesis of /ka/. Multiple assessments of tongue would be required to evaluate oral function, and the assessment of tongue thickness might have a different clinical meaning

Influence of microstructure on fatigue property of ultra high-strength steels

Ultra-high-strength steels (with tensile strength higher than 980 MPa) are widely used in automobile manufacturing owing to their lightweight that contributes to fuel efficiency. The fatigue strength of ultra-high-strength steels with a notch tends to decrease, which is known as the effect of notch sensitivity. In this study, 4-point bending fatigue tests were performed to examine the fatigue strength and notch sensitivity of four steels; namely 590 MPa class steel, 980 MPa class martensitic steel, 980 MPa class bainitic steel, and 980 MPa class precipitation hardening steel plates with three different stress concentration factors. The results indicate that the fatigue strength and notch sensitivity of 980 MPa class steel specimens were higher than those of 590 MPa class steel specimens. The notch sensitivities of tested plate specimens were lower than those reported for cylindrical specimens of bainitic ultra-high-strength steels. Fatigue crack observation revealed that the cracks initiated in 590 MPa class steel, 980 MPa class bainitic, and martensitic steel propagated vertically from the lowest bottom of notch. Although similar initial crack propagation pattern was detected in precipitation hardening steel, the crack changed direction when it reached the central part of the specimen

超音波検査を用いた嚥下音産生機序の解明

Background: Cervical auscultation is a technique frequently used for the screening of dysphagia. However, this method is difficult to evaluate objectively and it is unclear how sound is generated during the swallowing process. The aim of this study was to analyze the waveform of swallowing sound and clarify the sound production process using recordings of swallowing sounds and ultrasound images (USI), performed simultaneously. Materials and Methods: Commercial natural spring water and natural carbonated water were used in experiments 1 and 2, respectively. In experiment 1, a microphone was attached to the skin of the neck of 20 young participants and swallowing sounds were recorded and analyzed. In experiment 2, swallowing processes in three participants were recorded by a medical ultrasonography apparatus. The ultrasonic probe was placed on the skin over one of the thyroid cartilages or the thyroid gland. Results: The swallowing sound wave (SSW) was divided into three sectional periods. The mean duration of the first, second, and third SSW was 210 ± 147 ms, 458 ± 113 ms, and 91 ± 61 ms, respectively. The mean intensity ratio of the first, second, and third SSW was 7.8 ± 5.2, 29.2 ± 16.5, and 5.8 ± 5.1, respectively. When the ultrasonic probe was placed on the skin over one of the thyroid cartilages, in the phase between the production of the second SSW and the silent period, the USI revealed an accumulation of swallowed material around the valleculae and oropharynx. In the silent period of the second SSW, the swallowed material accumulated around the hypopharynx. When the ultrasonic probe was placed on the skin over the thyroid gland, in the silent period of the second SSW, the USI revealed that the swallowed material had passed through esophagus. Conclusion: Waveform and USI findings from this study suggest that swallowing sound can be divided into three sectional periods: an oral phase, a pharyngeal phase, and a repositioning phase

コウクウ ケア ト シカ イリョウ デバイス

Life expectancy in Japan is among the world's highest and aging population has been increasing. Oral care in the elderly has been focused on many medical facilities for prevention from aspiration pneumonia and hospital infections. Poor oral hygiene of the elderly can cause various problems not only in the mouth but also in general health. We have studied on denture plaque micro flora, saliva and the relationship between oral and systemic conditions for more than 15 years. The results of our studies showed the direct and indirect effects of oral care. This article describes on the inflectious problem by dental devices including denture plaque, and significance of oral care through our studies

Characterization of Swallowing Sound : Preliminary Investigation of Normal Subjects

Objective The purpose of this study was to characterize the swallowing sound and identify the process of sound generation during swallowing in young healthy adults. Methods Thirty-three healthy volunteers were enrolled and allocated into three experimental groups. In experiment 1, a microphone was attached to one of eight cervical sites in 20 subjects, participants swallowed 5 ml water, and the sound waveform was recorded. In experiment 2, 10 subjects swallowed either 0, 5, 10, or 15 ml water during audio recording. In addition, participants consumed the 5 ml bolus in two different cervical postures. In experiment 3, the sound waveform and videofluoroscopy were simultaneously recorded while the three participants consumed 5 ml iopamidol solution. The duration and peak intensity ratio of the waveform were analyzed in all experimental groups. Results The acoustic analysis of the waveforms and videofluoroscopy suggested that the swallowing sound could be divided into three periods, each associated with a stage of the swallowing movement: the oral phase comprising posterior tongue and hyoid bone movement; the pharyngeal phase comprising larynx movement, hyoid bone elevation, epiglottis closure, and passage of the bolus through the esophagus orifice; and the repositioning phase comprising the return of the hyoid bone and larynx to their resting positions, and reopening of the epiglottis. Conclusion Acoustic analysis of swallowing sounds and videofluoroscopy suggests that the swallowing sound could be divided into three periods associated with each process of the swallowing movement: the oral phase comprising the posterior movement of the tongue and hyoid bone; the pharyngeal phase comprising the laryngeal movement, hyoid bone elevation, epiglottis closure, and the bolus passage to the esophagus orifice; and the repositioning phase comprising the repositioning of the hyoid bone and larynx, and reopening of the epiglottis

The whole blood transcriptional regulation landscape in 465 COVID-19 infected samples from Japan COVID-19 Task Force

「コロナ制圧タスクフォース」COVID-19患者由来の血液細胞における遺伝子発現の網羅的解析 --重症度に応じた遺伝子発現の変化には、ヒトゲノム配列の個人差が影響する--. 京都大学プレスリリース. 2022-08-23.Coronavirus disease 2019 (COVID-19) is a recently-emerged infectious disease that has caused millions of deaths, where comprehensive understanding of disease mechanisms is still unestablished. In particular, studies of gene expression dynamics and regulation landscape in COVID-19 infected individuals are limited. Here, we report on a thorough analysis of whole blood RNA-seq data from 465 genotyped samples from the Japan COVID-19 Task Force, including 359 severe and 106 non-severe COVID-19 cases. We discover 1169 putative causal expression quantitative trait loci (eQTLs) including 34 possible colocalizations with biobank fine-mapping results of hematopoietic traits in a Japanese population, 1549 putative causal splice QTLs (sQTLs; e.g. two independent sQTLs at TOR1AIP1), as well as biologically interpretable trans-eQTL examples (e.g., REST and STING1), all fine-mapped at single variant resolution. We perform differential gene expression analysis to elucidate 198 genes with increased expression in severe COVID-19 cases and enriched for innate immune-related functions. Finally, we evaluate the limited but non-zero effect of COVID-19 phenotype on eQTL discovery, and highlight the presence of COVID-19 severity-interaction eQTLs (ieQTLs; e.g., CLEC4C and MYBL2). Our study provides a comprehensive catalog of whole blood regulatory variants in Japanese, as well as a reference for transcriptional landscapes in response to COVID-19 infection