216 research outputs found
<Abstract of Published Report>Recoverable Chiral Sulfoxide : Remote Asymmetric Induction in Lewis Acid-Promoted Diels-Alder Reaction of Chiral Sulfinyl-Substituted Pyrrolylα, β-Unsaturated Enones.
<Abstract of Published Report>Remote Asymmetric Induction in Lewis Acid Catalyzed Diels-Alder Reaction of α, β-Unsaturated Enones Having a Chiral Sulfinyl-substituted, 5-Membered Aromatic Heterocycle.
<Abstract of Published Report>Recoverable Chiral Sulfoxide : Asymmetric Diels-Alder Reaction Using Optically Active 1-(2-p-Tolylsulfinyl)pyrrolyl α, β-Unsaturated Ketones as a Dienophile
<Abstract of Published Report>Highly Stereoselective Aldol Reaction of Chiral 3-(p-Tolylsulfinyl)furfural with Silyl Ketene Acetal Catalyzed by Lanthanide Triflate
A Phase II Study of S-1 Monotherapy as a First-line Combination Therapy of S-1 Plus Cisplatin as a Second-line Therapy, and Weekly Paclitaxel Monotherapy as a Third-line Therapy in Patients with Advanced Gastric Carcinoma: A Second Report
Background We have previousy reported on a Phase II study of S-1 monotherapy as a first line, combination therapy of S-1 plus cisplatin as a second line, and weekly paclitaxel monotherapy as a third line therapy in patients with advanced gastric carcinomas. The median survival time (MST) of patients over the whole course of treatment was not previously calculated because 12 out of 19 patients had not yet succumbed. Since then, we have calculated the MST for this study and herein report our findings. Patients and Methods Between 2002 and 2005, 19 patients were enrolled in this study. Chemotherapy consisted of either 60 mg/m 2 of S-1 for 4 weeks at 6-week intervals, a combination of 60 mg/m 2 S-1 for 3 weeks and 60 mg/m 2 cisplatin on day 8 at 5-week intervals, or 60 mg/m 2 paclitaxel at days 1, 8, and 15, at 4-week intervals. The regimens were repeated until the occurrence of unacceptable toxicities, disease progression, or patient noncompliance. The primary end point was the overall survival. Results The median survival time was 774 days. The response rates were 33.3% (3/9), 12.5% (1/8), and 0% (0/4) after the first, second, and third line chemotherapies, respectively. The major adverse hematological toxicity was leukopenia, which reached grades 3–4 in all lines of chemotherapy investigated. In addition, the major adverse non-hematological toxicity was anorexia, which reached grade 3–4 in second line chemotherapy, and no deaths were attributable to the adverse effects of the drugs. Conclusion This sequential therapy was an effective treatment for advanced gastric cancer with acceptable toxic side-effects. We considered this therapy to be effective because of the smooth transition to the next regimen
Neutron scattering study on spin correlations and fluctuations in the transition-metal-based magnetic quasicrystal Zn-Fe-Sc
Spin correlations and fluctuations in the 3d-transition-metal-based
icosahedral quasicrystal Zn-Fe-Sc have been investigated by neutron scattering
using polycrystalline samples. Magnetic diffuse scattering has been observed in
the elastic experiment at low temperatures, indicating development of static
short-range-spin correlations. In addition, the inelastic scattering experiment
detects a -independent quasielastic signal ascribed to single-site
relaxational spin fluctuations. Above the macroscopic freezing temperature
K, the spin relaxation rate shows Arrhenius-type behavior,
indicating thermally activated relaxation process. In contrast, the relaxation
rate remains finite even at the lowest temperature, suggesting a certain
quantum origin for the spin fluctuations below .Comment: To be published in Phys. Rev.
Laboratory EXAFS Spectrometer with a Bent Crystal, a Solid-State Detector, and a Fast Detection System
<Abstract of Published Report>β-Lactam Synthesis by Diastereoselective Condensation of Chiral 3-(p-Tolylsulfinyl)-2-Furaldimine and Ester Enolates.
<Abstract of published report>A highly asymmetric, Lewis Acid-catalysed Diels-Alder reaction using optically active 2-(3-tolyl-p-sulfinyl)furyl α, β-unsaturated ketones as a dienophile.
<Abstract of published report>Highly Stereoselective Hetero Diels-Alder Reactions of Chiral 3-(p-Tolylsulfinyl)-2-furaldehyde with Danishefsky\u27s Diene Promoted by a Lanthanoid Lewis Acid.
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