Mathematical model of thermal operation of eontinuous furnace of mill 2250 of Alchevsk metallurgical industrial complex in coupled production

Using the developed mathematical model of coupled (external and internal) head exchange, allowing for the form and thermoprocessing peculiarities of the continuous pusher- type furnace, there are improved the temperature-thermal conditions of slabs heating in furnace of mill 2250 of Alchevsk metallurgical industrial complex

Calculation and experimental studies of the technology of heating steel billets in pusher furnaces

The article gives analytical solution to the problem of nonsymmetric heating of blooms in continuous fur­naces based on the '‘equivalent sources method’'. Para­metrical identification by the results of industrial experiments has shown sufficient accuracy and reliability of the method

Development of heating regimes of non-solidified ingots with mass 9,45-13,9 t in the regenerative fountains of the blooming department of ОАО "Alchevski metallurgical industrial complex"

The mechanism of heating of ingots with liquid heart, providing the increase of productivity and decrease of discharge intensity of standard coal, is investigated on the basis of mathematical modelling of the processes of solidification, cooling and heating of coarse blooming ingots as a unified combined heat technological process

Combined estrogenic and anti-estrogenic properties of estetrol on breast cancer may provide a safe therapeutic window for the treatment of menopausal symptoms

Increased risk of breast cancer is a critical side effect associated with the use of a menopausal hormone therapy (MHT). Estetrol (E4) is a natural estrogen produced by the human fetal liver and is a promising compound for clinical use in MHT. However, its impact on breast cancer is controversial and poorly defined. In this preclinical study, we show that E4 acts as a weak estrogen by stimulating the growth of hormone-dependent breast cancer only at concentrations exceeding menopausal therapeutic needs. E4 presents also an antitumor activity by decreasing the strong proliferative effect of estradiol (E2). While estrogen receptor alpha (ERα) is the predominant receptor mediating its effects, the dual weak-estrogenic/anti-estrogenic feature of E4 results from differential signaling pathways activation. Both nuclear and rapid extra-nuclear signaling pathway are necessary for a complete estrogenic effect of E4. However, the antitumor action of E4 is not due to a capacity to antagonize E2-induced nuclear activity. Altogether, our results highlight that E4 has a limited impact on breast cancer and may offer a safe therapeutic window for the treatment of menopausal symptoms.This work was supported by grants from the Fonds de la Recherche Scientifique - FNRS (F.R.S.-FNRS, Belgium) : FRSM 3.4557.12, FRSM 3.4567.11, Télévie 7.4524.11, Télévie 7.4604.13 ; the Fonds spéciaux de la Recherche (University of Liège) : FSRC- 12/64, FSRC-12/92, FSRC-14/89, FSRC-14/65, FSRC-14/109, FSRC-14/62 ; the Centre Anticancéreux près l’ Université de Liège, the Fonds Léon Fredericq (University of Liège), the Direction Générale Opérationnelle de l’Economie, de l’Emploi et de la Recherche from the Service Public de Wallonie (DGO6, SPW, Belgium) ; the Interuniversity Attraction Poles Programme - Belgian Science Policy (Brussels, Belgium) : IAP Phase VII - P7/03 ; the Plan National Cancer (Service Public Fédéral) and the Actions de Recherche Concertées (University of Liege, Belgium): A.R.C. 11/16-02

Analysis of temperature state of massive flat ingot in conditions of radiational contraflow

There is given the analysis of the task solution of counterflow heat exchange at heating of solids of classic form taking into account non-linearities of I and II type. As a mathematical apparatus there is used “the method of equivalent sources of energy”

Relationship between human tumor-associated antigen RCAS1 and gestational diabetes mellitus.

PROBLEM: The human tumor-associated receptor-binding cancer antigen expressed on SiSo cells (RCAS1) is considered to play a role in the inhibition of the maternal immune response during pregnancy. The aim of our study was to investigate the expression of RCAS1 protein in the placenta and to compare its concentration in maternal and cord blood sera between normal pregnancies and pregnancies complicated by gestational diabetes mellitus (GDM). METHOD OF STUDY: Samples were obtained from women with GDM (n = 8), women with type 1 DM (n = 5), and healthy term controls (n = 27) after delivery. Placentas were studied by immunohistochemistry, and real-time polymerase chain reaction. For assessment of RCAS1 concentrations in maternal and cord blood sera, enzyme-linked immunosorbent assay was performed. RESULTS: The RCAS1 protein mRNA expression in the placentas of patients with GDM was significantly lower than that in the controls (P = 0.005). The maternal blood RCAS1 protein concentration of the GDM cases was also significantly lower than that in the controls (P = 0.0411), whereas the cord blood RCAS1 protein concentration was significantly higher in the GDM and type 1 DM groups than in the controls (P = 0.0311 and P = 0.0192, respectively). CONCLUSION: The present results suggest that RCAS1 protein might have an important role in the development of GDM