3 research outputs found
Wound heating: Immunological aspects
Wound heating is a complex biological process, comprised of a series of
a sequential events aiming to repair injured tissue. The role of the
immune system in this process is not only to recognise and combat the
newly presented antigens at the site of injury, but also to participate
in the debridement of the damaged area and to contribute to the process
of heating. In this review, we discuss the molecules and cells of the
immune system that participate in tissue repair. We describe the
mechanisms of immune recognition during initial insult and the innate
and adaptive immune responses to injury. Finally, we address the role of
the immune system in regeneration and repair. (C) 2006 Elsevier Ltd. All
rights reserved
Reevaluation of the role of duration of morning stiffness in the assessment of rheumatoid arthritis activity.
OBJECTIVE: To evaluate the utility of the duration of morning stiffness (MS), as a patient-reported outcome (PRO), in assessing rheumatoid arthritis (RA) disease activity. METHODS: We acquired information on 5439 patients in QUEST-RA, an international database of patients with RA evaluated by a standard protocol. MS duration was assessed from time of waking to time of maximal improvement. Ability of MS duration to differentiate RA activity states, based on Disease Activity Score (DAS)28, was assessed by analysis of variance; and a receiver-operating characteristic (ROC) curve was plotted for discriminating clinically active (DAS28 > 3.2) from less active (DAS28 3.2). CONCLUSION: MS duration has a moderate correlation with RA disease activity. Assessment of MS duration may be clinically helpful in patients with low RAPID3 scores.</or=