Biofibre production from chicken feather

The global poultry industry generates at least 2 million tonnes of chicken feather every year. Feather fibre has potential as reinforcement for polymer composites with light-weight, thermal insulation and acoustic dampening properties. This study aimed to develop a process to produce clean fibre recovered from chicken feather. Raw feather was decontaminated by 0.15% sodium hypochlorite in 25 L water at pH 10.0 for two 30 min stages and cleaned by 0.15% hydrogen peroxide in 25 L water for three 30 min stages. Cleaned feather was comminuted in 300 L water using a centrifugal pump at 30 Hz impeller speed on full recycle for 4 h. Rachis and partially cut feather were removed using a 5 mm filter and fibre was recovered using a 1 mm filter. Wet fibre was dried in an air-forced oven at 70°C. Morphological studies revealed fibre surface remained intact after the treatment process

Biofibre Production from Chicken Feather

The global poultry industry generates at least 2 million tonnes of chicken feather every year. Feathers are currently hydrolysed into meal used for animal feed and fertilizer. Feather consists of 91% keratin, 1% lipid and 8% water. Raw feather also contains preen oil, offal, faecal matter and poultry processing water. Its morphology consists of barbs extending at an angle from a central hollow rachis. Impurities coat the entire feather, and particulates are trapped by layers of barbules and hooked barbicels holding adjacent barbs together. These substructures present an extensive and tortuous hydrophobic surface. Feather fibre is a multipurpose, cost effective reinforcement for polymer composites. Its incorporation in plastic, wood, concrete and cardboard makes the product lighter, insulate from heat loss and improve sound attenuation properties. The objective of this study was to develop a process to produce clean fibre recovered from chicken feather. In the treatment process, the heterogeneous characteristics of feather had to be considered. Raw feather was suspended in 25 L water in a pulper to be decontaminated using 2 stages of 0.1485% sodium hypochlorite adjusted to pH 10.0 with 1 M sodium hydroxide and cleaned in 3 stages of 0.15% hydrogen peroxide. The pulper disc impeller agitated the suspension at 10 Hz for 30 minute at each stage. Bacteriological tests confirmed pathogens such as Campylobacter, Salmonella and Enterobacteriaceae were removed during treatment. Off-white clean feathers were more than 10% whiter than dull yellow raw feather. Cleaned feather was comminuted in 300 L water using a centrifugal pump at a flow rate of 30Hz on full recycle for 4 hours. Rachis and partially cut feather were removed using a 5 mm aperture filter and fibre was recovered using a 1 mm filter. Wet fibre was dried to constant mass in an air-forced oven at 70°C. Fibre yield was 27% of feather input, or 54% of theoretical yield. Surface morphology showed no damage

Understanding Multiple Adoption in C2C Platforms in China

The network effect is the general principle that the value of connecting to a network depends on the number of existing customers in the network. Usually, the network effect makes strong firms stronger and weak firms weaker. In e-commerce, however, the power of network effects can be mitigated when users adopt multiple transaction platforms (i.e., multiple adoption). Owing to multiple adoption, emerging firms have a chance to compete with or surpass strong incumbents. This empirical study showed that, because of multiple adoption, smaller players can still exist in the face of a dominant player in China’s competitive online auction platforms

Media Richness and User Continuance to Instant Messaging

Media richness determines adoption of information systems. Insufficient research was done for investigating its influence on user continuance of using instant messaging applications. This study used classic IS and psychological theories to construct a research framework. This study gathered more than 200 responses by using an online form. LISREL software was used to conduct structural equation modeling technique to test the research framework. The findings indicated that various but not all dimensions of media richness positively contribute to users’ continuance to use instant messaging applications. Specific dimensions provide insights for managers to design their applications to effectively retain their users

Extensive hepatic infarction in severe preeclampsia as part of the HELLP syndrome (hemolysis, elevated liver enzymes, and low platelets): Evolution of CT findings and successful treatment with plasma exchange therapy

AbstractObjectiveWe describe the serial computed tomography (CT) findings of extensive hepatic infarction and successful plasma exchange therapy in a severe preeclamptic woman with postpartum HELLP syndrome.Case ReportA 38 year-old woman presented with elevated blood pressure of 140–180/90–120 mmHg and 3+ proteinuria at 28 weeks of gestation. Two days after admission, the patient suddenly complained of severe epigastric pain and headache. Her blood pressure rose sharply to 195/120 mmHg. A 980 g female was delivered by emergency cesarean section. Following delivery, the patient's clinical condition and laboratory values deteriorated, with progressive liver insufficiency (peak AST level = 4246 IU/L, ALT = 3685 IU/L, LDH = 6237 IU/L, platelets = 72,000/mm3). Two consecutive plasma exchanges (PEX) were undertaken on the 3rd and 4th postpartum day. A contrast-enhanced CT of the abdomen performed 8 days postpartum showed geographically wedge-shaped areas of low attenuation, with a mottled appearance in the right hepatic lobe. Shortly thereafter, the patient recovered and all laboratory parameters gradually normalized 3 weeks after delivery. Follow-up CT-scan of the liver 2 months postpartum showed no evidence of infarction, with complete recovery.ConclusionWe recommend that severely ill patients with HELLP syndrome having epigastric pain should undergo CT imaging of the liver. A trial of postpartum PEX therapy should be considered for treatment of the HELLP syndrome complicated with hepatic infarction, which is recalcitrant to conventional medical management, and fails to abate within 72–96 hours of delivery

2-Deoxy-D-glucose enhances TRAIL-induced apoptosis in human melanoma cells through XBP-1-mediated up-regulation of TRAIL-R2

Background: Past studies have shown that sensitivity of melanoma cells to TRAIL-induced apoptosis is largely correlated with the expression levels of TRAIL death receptors on the cell surface. However, fresh melanoma isolates and melanoma tissue sections express generally low levels of death receptors for TRAIL. The clinical potential of TRAIL in the treatment of melanoma may therefore be limited unless given with agents that increase the cell surface expression of TRAIL death receptors. 2-Deoxy-D-glucose (2-DG) is a synthetic glucose analogue that inhibits glycolysis and glycosylation and blocks cell growth. It has been in clinical evaluation for its potential use as an anticancer agent. In this study, we have examined whether 2-DG and TRAIL interact to enhance their cytotoxicity towards melanoma cells. Results: 2-DG did not kill melanoma cells, but enhanced TRAIL-induced apoptosis in cultured melanoma cells and fresh melanoma isolates. This was associated with increased activation of the caspase cascade and mitochondrial apoptotic pathway, and was blocked by inhibition of TRAIL-R2, and to a lesser extent, inhibition of TRAIL-R1. Treatment with 2-DG up-regulated TRAIL death receptors, in particular, TRAIL-R2, on the melanoma cell surface. Up-regulation of TRAIL-R2 was due to increased transcription that was not dependent on the transcription factors, p53 and CHOP. Instead, the IRE1α and ATF6 pathways of the unfolded protein response that were activated by 2-DG appeared to be involved. Moreover, XBP-1, which is known to be transcriptionally regulated by ATF6 and functionally activated by IRE1α, was found to play an important role in 2-DG-mediated transcriptional up-regulation of TRAIL-R2 in melanoma cells. Conclusion: These results indicate that 2-DG sensitizes human melanoma cells to TRAIL-induced apoptosis by up-regulation of TRAIL-2 via the ATF6/IRE1α/XBP-1 axis of the unfolded protein response. They suggest that 2-DG is a promising agent to increase the therapeutic response to TRAIL in melanoma