Legislative Documents

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Additional file 6: of High burden of birthweight-lowering genetic variants in Africans and Asians

Genetic risk burden for low birthweight among 26 global populations. Populations are shown in descending order of mean risk allele loads. Genetic risk burden of all birthweight-reducing alleles (a) and birthweight-reducing alleles with ancestral status (b) are included. (DOCX 169 kb

Additional file 2: of High burden of birthweight-lowering genetic variants in Africans and Asians

Comparison of weighted and unweighted genetic risk burden for low birthweight. The unweighted (a) and effect-size weighted (b) genetic risk burden (risk allele load on y-axis) of five super-populations is shown. (DOCX 67 kb

Additional file 8: of High burden of birthweight-lowering genetic variants in Africans and Asians

Published evidence for signals of recent positive selection in GWAS loci associated with birthweight. Interrogation of the http://jjwanglab.org/dbpshp database found a total of 14 birthweight GWAS loci (out of 59 autosomal loci analyzed) overlapping with previously known signals of recent positive selection. (DOCX 21 kb

Additional file 3: of High burden of birthweight-lowering genetic variants in Africans and Asians

Genetic risk burden for low birthweight among five super-populations. The median genetic risk burden for each super-population is shown in the y-axis. Figures include burden for all 59 SNPs, and the ancestral and derived alleles. (DOCX 95 kb

Additional file 5: of High burden of birthweight-lowering genetic variants in Africans and Asians

P values from pairwise comparisons of genetic risk burden of birthweight-lowering alleles in 26 global populations. Colors of cells in the first row and first column indicate super-populations as indicated. P values <0.05 in comparison of populations belonging to the same super-population are in bold and highlighted in yellow. (DOCX 33 kb

Associations between body iron status and the SNPs in <i>TPMRSS6</i>, <i>HFE</i>, and <i>TF</i> genes in NHS.

*<p>the first allele of each SNP is effect allele.</p

Associations of SNPs in <i>TPMRSS6</i>, <i>HFE</i>, and <i>TF</i> genes with the risk T2D in NHS and HPFS.

*<p>Adjusted for age, BMI (<23.0, 23.0–24.9, 25.0–29.9, 30.0–34.9, or ≥35.0 kg/m² ), family history of diabetes (yes, no), smoking (never, past, current), alcohol (nondrinker or drinker [0.1–4.9, 5.0–9.9, 10.0–14.9 or ≥15.0 g/day]), menopausal status [pre- or post-menopausal (never, past, or current hormone use); women only], quintiles of physical activity (metabolic equivalent task hours/wk for men in HPFS, hours/wk for women in NHS), and quintiles of energy adjusted P:S ratio, <i>trans</i>-fat and cereal fiber intakes.</p

Risk factor characteristics of T2D cases and controls at baseline in NHS and HPFS^*.

*<p>Values are means (SD) unless otherwise indicated. BMI  =  body mass index; PMH  =  post-menopausal hormone.</p>†<p>Test of differences between cases and controls: χ2 for categorical and T-tests for continuous variables.</p>‡<p>Metabolic equivalent task hours/wk for men in HPFS and hours/wk for women in NHS.</p

Associations between tertiles of genetic risk score and type 2 diabetes risk in HPFS.

<p>Associations between tertiles of genetic risk score and type 2 diabetes risk in HPFS.</p