Synthesis and reduction of steroid C-20 alkylidene cyanoacetates

The geometry of the condensation products between ethyl cyanoacetate and 20-ketosteroids (5α-pregnane-20-one, 3β-hydroxypregn-5-en-20-one and 3β-acetoxypregn-5-en-20-one) was established by NMR spectra. Reduction of these steroid C-20 alkylidene cyanoacetates was shown to afford one of the two possible C-20 epimers, which seem to correspond to the 20β-methyl configuration. © 1979

Comparative in vitro study of the sealing efficiency of white vs grey ProRoot mineral trioxide aggregate formulas as apical barriers

Mineral trioxide aggregate (MTA) has been proposed as one of the materials which can be used in a one-visit apexification technique. Recently conventional grey MTA has been replaced by a new white MTA formula. The aim of this study was to compare the root canal adaptation of white MTA to that of grey MTA when used as an apical barrier in teeth with open apices. We also examined whether a previous calcium hydroxide intracanal medication affects MTA's sealing ability and investigated the ability to remove calcium hydroxide from the root canal walls. Forty-nine teeth were prepared in a manner to simulate a divergent open apex of immature teeth. Four teeth were used in a preliminary experiment to demonstrate the inefficacy of calcium hydroxide removal from the canal walls in teeth with open apices. Four groups of 10 teeth each were created: groups A and B were treated with calcium hydroxide intracanal medication and then received an apical plug of grey and white MTA respectively. Groups C and D received an apical plug of grey and white MTA respectively without previous intracanal medication. Four teeth served as negative and one as a positive control. The marginal adaptation and sealing ability of the apical barrier were tested by means of a dye tracer (basic fuchsine) after longitudinal sectioning. It was found that MTA apical barrier resisted displacement during gutta-percha condensation. Calcium hydroxide pretreatment, adversely affected white MTA sealing ability (P < 0.05). © 2008 Blackwell Munksgaard

Synthesis and pharmacological activity of new basic carbamates

A series of bicarbamates of N-phenethyldiethanolamine, 2-diethylamino- and 2-piperidino-1,3-propanediol, and N-methyldiethanolamine, were synthesized and their nonoxalate soluble salts were evaluated in a primary mouse screen. In secondary studies, bis(N-butylcarbamoylethyl)-2,3-dimethoxyphenethylamine maleate (17) showed mild CNS depressant activity while another compound, bis-(N-phenylcarbamoylethyl)-2-n-butoxy-3-methoxyphenethylamine hydrochloride (5), exhibited antidepressant activity. Both decreased blood pressure

Synthesis and Pharmacological Activity of Alkylaminoalkyl Esters and Amides of 2-Hydroxy-(or Alkoxy-)3-methoxybenzoic Acid

A series of alkylaminoalkyl esters and amides of 2-hydroxy-(or alkoxy-)3-methoxybenzoic acid were synthesized and their hydrochloride, methiodide, or oxalate salts were tested for local anesthetic activity. Only the diethylamino and n-butylamino ethyl esters of 2-butoxy-3-methoxybenzoic acid and morpholinoethyl 2-ethoxy-3-methoxybenzoate exhibited greater local anesthetic activity than lidocaine. However, these compounds were highly irritating and generally more toxic. © 1969, American Chemical Society. All rights reserved