Gary Snyder, nature and ecological communication

99學年度蔡振興教師升等代表著作[[booktype]]紙

Neutrino mass generation and H → γγ/Zγ correlation with scalar multiplets

One natural way to understand the excess of the measured H → γγ rate over the standard model (SM) expectation at the Large Hadron Collider (LHC) is to have charged scalar bosons, existing in most of the SM extensions. Motivated by this LHC result, we explore if it also sheds light on solving the small neutrino mass generation problem. We concentrate on a class of models with high-dimensional representations of scalars to realize Majorana neutrino masses at the two-loop level without imposing any new symmetry. In these models, multi scalars with electric charges higher than two are naturally expected, which not only enhance the H → γγ rate, but provide more searching grounds at the LHC. In particular, the rate of H → Zγ is also correlated to that of the diphoton channel

A Bayesian measurement error model for two-channel cell-based RNAi data with replicates

RNA interference (RNAi) is an endogenous cellular process in which small double-stranded RNAs lead to the destruction of mRNAs with complementary nucleoside sequence. With the production of RNAi libraries, large-scale RNAi screening in human cells can be conducted to identify unknown genes involved in a biological pathway. One challenge researchers face is how to deal with the multiple testing issue and the related false positive rate (FDR) and false negative rate (FNR). This paper proposes a Bayesian hierarchical measurement error model for the analysis of data from a two-channel RNAi high-throughput experiment with replicates, in which both the activity of a particular biological pathway and cell viability are monitored and the goal is to identify short hair-pin RNAs (shRNAs) that affect the pathway activity without affecting cell activity. Simulation studies demonstrate the flexibility and robustness of the Bayesian method and the benefits of having replicates in the experiment. This method is illustrated through analyzing the data from a RNAi high-throughput screening that searches for cellular factors affecting HCV replication without affecting cell viability; comparisons of the results from this HCV study and some of those reported in the literature are included.Comment: Published in at http://dx.doi.org/10.1214/11-AOAS496 the Annals of Applied Statistics (http://www.imstat.org/aoas/) by the Institute of Mathematical Statistics (http://www.imstat.org

Effect on Higgs Boson Decays from Large Light-Heavy Neutrino Mixing in Seesaw Models

In seesaw models with more than one generation of light and heavy neutrinos, nu and N, respectively, it is possible to have sizable mixing between them for heavy-neutrino masses of order 100 GeV or less. We explore this possibility further, taking into account current experimental constraints, and study its effect on Higgs-boson decays in the contexts of seesaw models of types I and III. We find that in the type-I case the Higgs decay into a pair of light and heavy neutrinos, h -> nu N, could increase the total Higgs width in the standard model by up to almost 30% for a relatively light Higgs-boson, which would significantly affect Higgs searches at the LHC. The subsequent prompt decay of N into three light fermions makes this Higgs decay effectively a four-body decay. We further find that, in the presence of the large light-heavy mixing, these four-body Higgs decays can have rates a few times larger than their standard-model counterparts and therefore could provide a potentially important window to reveal the underlying seesaw mechanism.Comment: 16 pages, 3 figures, with more discussion on experimental constraints and references, main conclusions unchanged, to match journal versio

(Z)-4-(2-Hy­droxy­benzyl­idene)-1-methyl-2-phenyl-1H-imidazol-5(4H)-one

In the title compound, C17H14N2O2, the asymmetric unit comprises two mol­ecules that are comformationally similar [the dihedral angles between the phenyl rings in each are 46.35 (2) and 48.04 (3)°], with the conformation stabilized by intra­molecular O—H⋯N hydrogen bonds, which generate S(7) rings. In the crystal, inversion-related mol­ecules are linked by pairs of weak C—H⋯O hydrogen bonds, forming dimers with an R 2 2(16) graph-set motif. Weak inter-ring π–π stacking is observed in the structure, the shortest centroid-to-centroid distance being 3.7480 (13) Å

(E)-4-[(4-Diethyl­amino-2-hy­droxy­benzyl­idene)amino]­benzonitrile

The title compound, C18H19N3O, displays an E conformation with respect to the C=N double bond. The dihedral angle between the mean planes of the two benzene rings is 24.49 (3)°. An intra­molecular O—H⋯N hydrogen bond generates an S(6) ring. In the crystal, mol­ecules are linked by nonclassical inter­molecular C—H⋯O hydrogen bonds to form an infinite one-dimensional chain along [010], generating a C(8) motif

Smoking, Habitual Tea Drinking and Metabolic Syndrome in Elderly Men Living in Rural Community: The Tianliao Old People (TOP) Study 02

The literature shows an inconsistent relationship between lifestyle behaviors and metabolic syndrome (MetS), especially in the elderly. We designed this study to investigate the interrelationships among cigarette smoking, tea drinking and MetS, and to verify the factors associated with MetS in elderly males dwelling in rural community. In July 2010, with a whole community sampling method, 414 male subjects aged over 65 dwelling in Tianliao township were randomly sampled. The response rate was 60.8%. Each subject completed the structured questionnaires including sociodemographic characteristics, habitual behaviors (including cigarette smoking and tea drinking habits) and medical history. After an overnight fast, the laboratory and anthropometric data were obtained. MetS was confirmed according to the criteria defined by the modified NCEP ATP III for the male Chinese population. Subjects were split into either non-MetS or MetS groups for further analysis. Of the 361 subjects with complete data, 132 (36.6%) elderly men were classified as having MetS. Using binary logistic regression, body mass index, serum uric acid, high sensitivity C-reactive protein, HOMA index, current smokers (OR = 2.72, 95%CI: 1.03 ∼ 7.19), total smoking amount > = 30 (OR = 2.78, 95%CI: 1.31 ∼ 5.90) and more than 20 cigarettes daily (OR = 2.54, 95%CI: 1.24 ∼ 5.18) were positively associated with MetS. Current un- or partial fermented tea drinker (OR = 0.42, 95%CI: 0.22 ∼ 0.84), tea drinking habit for 1–9 years (OR = 0.36, 95%CI: 0.15 ∼ 0.90) and more than 240cc daily (OR = 0.35, 95%CI: 0.17 ∼ 0.72) were negatively associated with MetS. In conclusion, this study suggests that smoking habit was positively associated with MetS, but tea drinking habit was negatively associated with MetS in elderly men dwelling in rural community

Multi high charged scalars in the LHC searches and Majorana neutrino mass generations

Abstract One natural way to understand the excess of the measured H → γγ rate over the standard model (SM) expectation at the Large Hadron Collider (LHC) is to have charged scalar bosons, existing in most of the SM extensions. Motivated by this LHC result, we explore if it also sheds light on solving the small neutrino mass generation problem. We concentrate on a class of models with high dimensional representations of scalars to realize Majorana neutrino masses at two-loop level without imposing any new symmetry. In these models, multi scalars with the electric charges higher than two are naturally expected, which not only enhance the H → γγ rate, but provide more searching grounds at the LHC. In particular, the rate of H → Zγ also changes similar to that of the diphoton channel

A White-Light-Emitting Small Molecule: Synthesis, Crystal Structure, and Optical Properties

A white-light-emitting small molecule (1) was synthesized and characterized by single-crystal X-ray diffraction. Compound 1 undergoes an excited-state intramolecular proton transfer (ESIPT) reaction, resulting in a tautomer that is in equilibrium with the normal species and exhibiting a dual emission that covers almost all of the visible spectrum, and consequently generates white light. Furthermore, the geometric structures, the frontier molecular orbitals (MOs), and the potential energy curves for 1 in the ground and the first singlet excited state were fully rationalized by density functional theory (DFT) and time-dependent DFT calculations. The results show that the forward ESIPT and backward ESIPT may happen on the same timescale, enabling the excited-state equilibrium to be established

Mechanism of Evolution Shared by Gene and Language

We propose a general mechanism for evolution to explain the diversity of gene and language. To quantify their common features and reveal the hidden structures, several statistical properties and patterns are examined based on a new method called the rank-rank analysis. We find that the classical correspondence, "domain plays the role of word in gene language", is not rigorous, and propose to replace domain by protein. In addition, we devise a new evolution unit, syllgram, to include the characteristics of spoken and written language. Based on the correspondence between (protein, domain) and (word, syllgram), we discover that both gene and language shared a common scaling structure and scale-free network. Like the Rosetta stone, this work may help decipher the secret behind non-coding DNA and unknown languages.Comment: 15 pages, 13 figures, 3 tabl