The Disequilibrium of Nucleosomes Distribution along Chromosomes Plays a Functional and Evolutionarily Role in Regulating Gene Expression

To further understand the relationship between nucleosome-space occupancy (NO) and global transcriptional activity in mammals, we acquired a set of genome-wide nucleosome distribution and transcriptome data from the mouse cerebrum and testis based on ChIP (H3)-seq and RNA-seq, respectively. We identified a nearly consistent NO patterns among three mouse tissues—cerebrum, testis, and ESCs—and found, through clustering analysis for transcriptional activation, that the NO variations among chromosomes are closely associated with distinct expression levels between house-keeping (HK) genes and tissue-specific (TS) genes. Both TS and HK genes form clusters albeit the obvious majority. This feature implies that NO patterns, i.e. nucleosome binding and clustering, are coupled with gene clustering that may be functionally and evolutionarily conserved in regulating gene expression among different cell types

Chronic lung diseases are associated with gene expression programs favoring SARS-CoV-2 entry and severity

Patients with chronic lung disease (CLD) have an increased risk for severe coronavirus disease-19 (COVID-19) and poor outcomes. Here, we analyze the transcriptomes of 611,398 single cells isolated from healthy and CLD lungs to identify molecular characteristics of lung cells that may account for worse COVID-19 outcomes in patients with chronic lung diseases. We observe a similar cellular distribution and relative expression of SARS-CoV-2 entry factors in control and CLD lungs. CLD AT2 cells express higher levels of genes linked directly to the efficiency of viral replication and the innate immune response. Additionally, we identify basal differences in inflammatory gene expression programs that highlight how CLD alters the inflammatory microenvironment encountered upon viral exposure to the peripheral lung. Our study indicates that CLD is accompanied by changes in cell-type-specific gene expression programs that prime the lung epithelium for and influence the innate and adaptive immune responses to SARS-CoV-2 infection

THE SPECTRUM OF THE MÖSSBAUER RADIATION PASSED THROUGH A VIBRATING RESONANT MEDIUM

No abstract availabl

Многомерни операционни смятания за нелокални гранични задачи за еволюционни уравнения

[Dimovski Ivan H.; Димовски Иван Х.]; [Tsankov Yulian Ts.; Цанков Юлиан Ц.]Here we propose a direct operational calculus approach to nonlocal boundary value problems for a large class of linear evolution equations with several space variables and one time variable. PACS: 44A35, 44A45, 35K20, 35K15, 35J25

Точни решения на задачата на Бицадзе-Самарски и някои обобщения

[Dimovski Ivan H.; Димовски Иван Х.]; [Tsankov Yulian Ts.; Цанков Юлиан Ц.]Mathematics Subject Classification (2000): 44A35, 35L20, 35J05, 35J25

Точни решения на нелокални гранични задачи за двумерното уравнение на топлопроводността

[Dimovski Ivan H.; Димовски Иван Х.]; [Tsankov Yulian Ts.; Цанков Юлиан Ц.

Plasma parameters and tungsten sputter rates in a high-frequency CCP

Monitoring and investigating the fusion plasma in ITER will be crucial to pave the way to a fusion power plant. However, the harsh conditions in the vacuum vessel are detrimental for the optical diagnostics systems. Replacing the element with a direct line of sight to the fusion plasma by a metallic mirror shifts the problem to this component. The flux of impurities onto these mirrors accumulate to deposits, which degrade their optical properties over time. It has been proposed to address this issue by igniting discharges in front of the mirrors during the maintenance phases allowing the deposited material to be sputtered away and recover the mirror properties. To further the knowledge for such an option, in this work, plasma parameters and sputter rates in a high-frequency (60 MHz) capacitive discharge in argon at pressures below 10 Pa are studied. The powered electrode consists of tungsten as a cheap rhodium proxy—the material of the metallic mirrors in ITER—and to simulate tungsten deposition. Its size is equivalent to a mirror for charge-exchange recombination spectroscopy at ITER (8.5 cm × 18 cm). The discharge is studied using and interpreting voltage measurements, microwave interferometry, electrical probe measurements, and optical emission spectroscopy. These investigations provide the opportunity to identify the optimal conditions for the process based on various requirements, such as damage threshold of the mirror crystal and severity and type of contamination