DNA replication licensing in stem cells: Gatekeeping the commitment to proliferation.

Carroll et al. (2018. J. Cell Biol. https://doi.org/10.1083/jcb.201708023) developed a method to assess DNA replication licensing in tissues. They show that intestinal stem cells within wild-type crypts, but not in crypts with cancer-causing mutations, are largely unlicensed, suggesting that licensing may represent a rate-limiting step in the commitment to proliferation

Shared Autonomous Mobility Services Show Promise for Increasing Access to Employment in Southern California

Workers in Southern California currently face transportationrelated challenges accessing employment opportunities, including but not limited to high parking costs and/or limited parking availability in dense employment and residential areas; long commute distances between residential areas and employment opportunities; and poor transit service quality in many areas. These challenges are particularly burdensome for low-income households that may not have access to a personal vehicle and/or live in jobpoor neighborhoods, as having a personal vehicle may be the only viable way to get to work

Thiotepa hyperpigmentation preceding epidermal necrosis: malignant intertrigo misdiagnosed as Stevens-Johnson syndrome-toxic epidermal necrolysis overlap

Thiotepa is a common alkylating agent known to precipitate cutaneous reactions consistent with toxic erythema of chemotherapy, including erythema and hyperpigmentation. Herein, we describe an atypical case of malignant intertrigo involving preferential erythema and desquamation not only of skin folds but also of occluded areas after thiotepa-based conditioning. The diagnosis was complicated by concurrent stomatitis and oral petechiae in the setting of autologous stem cell transplant 11 days prior for diffuse large B-cell lymphoma. Histopathological examination from two cutaneous sites demonstrated epidermal dysmaturation and eccrine gland necrosis consistent with thiotepa-induced desquamation and not Stevens-Johnson syndrome or graft-versus-host-disease. Malignant intertrigo can present with extensive cutaneous involvement, as evidenced by our patient who had 25% body surface area affected. Mucosal involvement is common with most chemotherapeutic regimens and its presence should not deter the astute clinician from consideration of a diagnosis of toxic erythema of chemotherapy. No further interventions were needed and the patient healed spontaneously

In Re: Mac Truong

USDC for the District of New Jerse

In Re: Mac Truong

USDC for the District of New Jerse

Giau Minh Truong Interview

Bio: Giau Minh Truong is a company member of A-Squared Theatre Workshop and an at- large artist for various performing arts companies in the Chicago area. For A-Squared, he directed Ching Chong Chinaman, The Other Shore, and short plays for My Asian Mom, acted in Trial By Water, and designed lights for The Wind Cries Mary. Giau’s other directorial credits include Downward Facing, Lights Out, Everybody, and Theatre of Women for Dream Theatre Company. He directed Sister Outlaw, Mr. and Mrs. LaQuesta Go Dancing, My Name is Flor Contemplacion, and I Dream Electric for CIRCA-Pintig, Chicago’s long-running Filipino American theatre company for which he served as artistic director from 2007 through 2012. Giau has also directed plays for James Downing Theatre Company and Theatre for a Change. He serves as a teaching artist and program manager for Storycatchers, stage manages with Chamber Opera Chicago and various other companies and is a resident technical director for Links Hall. (Bio taken from https://halcyontheatre.org/people/giautruong

Impact Assessment of Emissions Stabilization Scenarios with and without Induced Technological Change

The main aim of this paper is to investigate quantitatively the economic impacts of emissions stabilization scenarios with and without the inclusion of induced technological change (ITC). Improved technological innovations are triggered by increased R&D expenditures that advance energy efficiencies. Model results show that induced technological changes due to increased investment in R&D reduce compliance costs. Although R&D expenditures compete with other investment expenditures, we find that increased R&D expenditures improve energy efficiency which substantially lowers abatement costs. Without the inclusion of induced technological change, emissions targets are primarily reached by declines in production, resulting in overall welfare reductions. With the inclusion of induced technological changes, emissions mitigations can result in fewer production and GDP drawbacks.Impact assessment of climate policy; Technological change