1,135 research outputs found

    The Statistics of Superdirective Beam Patterns

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    Superdirective arrays have been extensively studied because of their considerable potential accompanied, unfortunately, by a high sensitivity to random errors that affect the responses and positions of array elements. However, the statistics of their actual beam pattern (BP) has never been systematically investigated. This paper shows that the Rician probability density function (PDF), sometimes adopted to study the impact of errors in conventional arrays, is a valid approximation for superdirective BP statistics only where some mathematical terms are negligible. The paper also shows that this is the case for all linear end-fire arrays considered. A similar study is proposed concerning the correlation between BP lobes, showing that for the superdirective arrays considered the lobes, especially non-adjacent ones, are almost independent. Furthermore, knowledge of the PDF of the actual BP allows one to define quantile BP functions, whose probability of being exceeded, at any point, is fixed. Combining the lobes' independence with quantile BP functions, an empirical equation for the probability that the entire actual BP will not exceed a quantile function over an interval larger than a given size is obtained. This new knowledge and these tools make it possible to devise new methods to design robust superdirective arrays via optimization goals with clearer and more relevant statistical meaning

    Towards a new seismic short-term prediction methodology for critical service operators and manufacturing companies against earthquake

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    This paper is concerned with the novel short-term and operational-term seismic hazard assessment approach within the critical service operators and the manufacturing industry. The Cosmetecor earthquake prediction methodology has been tested and validated in the recent two decades. A prototype, Kuznetsov method, for exploring the Earth's interior has been used to create global monitoring network, which automatically detects spatial-temporal clusters and identifies electric potential anomalies. Research team developed the mathematical modelling of proton migration in terms of the fundamental Vlasov-Maxwell equation to convert original time series into visualization of electromagnetic wave. A 2-layer neural network model is used to fine-grained classification. Further, the statistical and scaling laws of seismicity have been exploited to present case of earthquake seasonality, i.e., a dataset of abnormal seismic scenarios for machine learning task. Finally, authors evaluated results in terms of reliability and accuracy of earthquake warnings at M5.2 threshold in Kamchatka: 17% of all warning represent missed alerts, and 83% represent correct alerts where events occurred in a 10-year time horizon. Common outcome in almost every case is mean lead time (time horizon) of 11.62 days. The dispersion is 6.7 days. Further, a non-random sample of the Italian companies assessed new benefits of methodology during survey. The stakeholders confirmed that they will be able to activate business continuity plan to mitigate earthquake consequences in a specific time frame. It is anticipated the emergence of new risk management practices on the Cosmetecor-based high technology of the 21st century, and the replacement of the long-term, one-in-a-hundred-year return period, assessment with a short-term, seasonal, seismic risk assessment

    What is value in the New Space Economy? The end-users’ perspective on satellite data and solutions

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    New industrial dynamics are disrupting the space sector. New stakeholders bringing in capital, technologies, and knowledge from other industries are developing next-generation space infrastructures and services. Both commercial and institutional space projects have to be valuable for a wider set of end-users, asking not only for economic returns but also social and environmental benefits. Space organizations urge understanding and fostering value in the New Space Economy ecosystem. Indeed, end-users are still struggling to enact the expected value of satellite data and solutions for their business. This paper aims to investigate the expected value and the level of adoption (enacted value) of satellite data and satellite-based solutions in the New Space Economy ecosystem from end-users’ perspective. We interviewed 21 managers from end-user organizations in different sectors (i.e., Insurance & Finance, Energy & Utility, Transportation & Logistics). Value is deeply discussed in general management literature, and we identify Value Theory as the theoretical lens with the most explanatory power for the phenomenon under examination. From the end-users’ perspective, we frame the expected value and the enacted value in taking strategic and tactical decisions regarding their activities, services and products, laying the foundations for further studies of value mechanisms in the New Space ecosystem. Our research set a theoretical and conceptual foundation on value in the New Space ecosystem. It also delineates the blurred boundaries of the New Space ecosystem, the main stakeholders involved, and their perception of value. Insights and implications for strategic and innovation management are also provided. Practitioners may exploit our research results and leverage the end-users-oriented framework to develop next-generation space projects in the New Space ecosystem. We also discuss the limitations and further developments of this research

    Evidence for engraftment of human bone marrow cells in non-lethally irradiated baboons

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    Background. Prior to organ harvesting, an attempt was made to modulate the donor's immune responses against prospective xenogeneic recipients by infusion of 'recipient-type' bone marrow. Methods. For this purpose, baboons conditioned with total lymphoid irradiation were given 6x108 unmodified human bone marrow cells/kg body weight with no subsequent treatment. Results. Animals survived until they were euthanized at 18 months. Using primers specific for human chorionic gonadotrophin gene, the presence of human DNA was confirmed by polymerase chain reaction in the blood of one animal for up to 18 months after cell transplantation; in the other animal, xenogeneic chimerism became undetectable in the blood at 6 months after bone marrow infusion. However, tissue samples obtained from both animals at the time they were euthanized bad evidence of donor (human) DNA. Additionally, the presence of donor DNA in individually harvested colonies of erythroid and myeloid lineages suggested that infused human bone marrow cells had engrafted across the xenogeneic barrier in both baboons. Conclusions. Bone marrow transplantation from human to baboon leads to establishment of chimerism and modulation of donor-specific immune reactivity, which suggests that this strategy could be reproducibly employed to crease 'surrogate' tolerogenesis in prospective donors for subsequent organ transplantation across xenogeneic barriers

    Multistationary and Oscillatory Modes of Free Radicals Generation by the Mitochondrial Respiratory Chain Revealed by a Bifurcation Analysis

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    The mitochondrial electron transport chain transforms energy satisfying cellular demand and generates reactive oxygen species (ROS) that act as metabolic signals or destructive factors. Therefore, knowledge of the possible modes and bifurcations of electron transport that affect ROS signaling provides insight into the interrelationship of mitochondrial respiration with cellular metabolism. Here, a bifurcation analysis of a sequence of the electron transport chain models of increasing complexity was used to analyze the contribution of individual components to the modes of respiratory chain behavior. Our algorithm constructed models as large systems of ordinary differential equations describing the time evolution of the distribution of redox states of the respiratory complexes. The most complete model of the respiratory chain and linked metabolic reactions predicted that condensed mitochondria produce more ROS at low succinate concentration and less ROS at high succinate levels than swelled mitochondria. This prediction was validated by measuring ROS production under various swelling conditions. A numerical bifurcation analysis revealed qualitatively different types of multistationary behavior and sustained oscillations in the parameter space near a region that was previously found to describe the behavior of isolated mitochondria. The oscillations in transmembrane potential and ROS generation, observed in living cells were reproduced in the model that includes interaction of respiratory complexes with the reactions of TCA cycle. Whereas multistationarity is an internal characteristic of the respiratory chain, the functional link of respiration with central metabolism creates oscillations, which can be understood as a means of auto-regulation of cell metabolism. © 2012 Selivanov et al

    Yes, construction cost, time and scope are important, but there is more: a new action plan for infrastructure success

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    Purpose: During the planning and delivery, iron triangle criteria, are essential for internal stakeholders (e.g. owner, sponsors and delivery company), mostly ignoring external stakeholders such as local communities (often perceived as inconvenient) or end users. In the medium-long term, infrastructure cost and benefit are far more important for external stakeholders and the environment. Design/methodology/approach: The iron triangle criteria, i.e. delivering on time, budget and quality/scope, is the traditional perspective to assess the success of infrastructure projects. Delivering on cost and time is significant, but particularly for infrastructure, there are more relevant success criteria. The authors argue which criteria are important, and explain why. Findings: The authors challenge the traditional view of judging projects based on respecting time, budget and quality/scope. The authors explain that discussing the social value and contribution to achieving the UN Sustainable Development Goals (SDGs) is extremely relevant. Crucially these metrics keep changing, even after the project is terminated. Originality/value: The authors provide a new seven-step action plan for decision-makers to improve infrastructure provision by reflecting on SDGs and engaging with external stakeholders, particularly minorities and the weaker members of their communities. Such an action plan is focused on the cost and value for different stakeholders on different timeframes and progress toward social value and achieving SDGs
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