Manipulation of Auditory Feedback in Individuals with Normal Hearing and Hearing Loss

Auditory feedback, the hearing of one’s own voice, plays an important role in the detection of speech errors and the regulation of speech production. The limited auditory cues available with a hearing loss can reduce the ability of individuals with hearing loss to use their auditory feedback. Hearing aids are a common assistive device that amplifies inaudible sounds. Hearing aids can also change auditory feedback through digital signal processing, such as frequency lowering. Frequency lowering moves high frequency information of an incoming auditory stimulus into a lower frequency region where audibility may be better. This can change how speech sounds are perceived. For example, the high frequency information of /s/ is moved closer to the lower frequency area of /ʃ/. As well, real-time signal processing in a laboratory setting can also manipulate various aspects of speech cues, such as intensity and vowel formants. These changes in auditory feedback may result in changes in speech production as the speech motor control system may perceive these perturbations as speech errors. A series of experiments were carried out to examine changes in speech production as a result of perturbations in the auditory feedback in individuals with normal hearing and hearing loss. Intensity and vowel formant perturbations were conducted using real-time signal processing in the laboratory. As well, changes in speech production were measured using auditory feedback that was processed with frequency lowering technology in hearing aids. Acoustic characteristics of intensity of vowels, sibilant fricatives, and first and second formants were analyzed. The results showed that the speech motor control system is sensitive to changes in auditory feedback because perturbations in auditory feedback can result in changes in speech production. However, speech production is not completely controlled by auditory feedback and other feedback systems, such as the somatosensory system, are also involved. An impairment of the auditory system can reduce the ability of the speech motor control system to use auditory feedback in the detection of speech errors, even when aided with hearing aids. Effects of frequency lowering in hearing aids on speech production depend on the parameters used and acclimatization time

The Microrna 29 family and its regulation

Since miRNAs have broad effects on tissue homeostasis, and disease development, it is particularly interesting to work out how miRNAs themselves are being regulated. Such data could provide crucial information for further understanding the mechanism underlying disease development and for being able to manipulate these miRNAs therapeutically. Generally, the expression of miRNAs can be regulated transcriptionally, epigenetically, or controlled by different stimuli e.g. cytokines and growth factors. In review, just transcription factors, cytokines, and growth factors controlling the miR-29 family expression in human diseases were for the first time investigated

A Simple Procedure for Extraction of Surface Protein of Salmonella Serotypes and Escherichia coli Strains Isolated from Poultry and Pigs

Salmonella and E.coli possess different surface protein structures that can induce protective immune responses. Identification of these proteins capacitates development of diverse applications in prevention and diagnosis that contribute to effectively control disease-causing enterobacteria pathogens such as Salmonella and E.coli. A simple procedure for obtaining protein complexes of Salmonella serotypes and E.coli is performed in this study. A sonication process with heat treatment of whole bacteria induced the release of protein complexes. Concentration of the protein extract was quantified using protein quantification Kits-Rapid, and protein complex profile was obtained by SDS-PAGE (Sodium dodecyl sulfate polyacrylamide gel electrophoresis) and silver staining. The concentrations of protein ranged from 29.45 to 45.35 µg/mL in the  Salmonella protein extracts, and from 25.35 to 36.72 µg/mL in the E.coli protein extracts. Six major groups of proteins from E. coli (YfiO, NipB, OmpF, YfgL, Talc, YaeT) and four major groups of proteins from Salmonella (Flagellin, OmpA, Porin, SEF21) were preliminarily determined by a simple procedure of extraction based on the molecular weight

POTENTIAL BENEFITS OF ARBUSCULAR MYCORRHIZA FUNGI IN SUSTAINABLE AGRICULTURAL CULTIVATION

The Arbuscular Mycorrhiza fungi have a mutualistic relationship with 80% of terrestrial plants. Arbuscular Mycorrhiza fungi are considered as a biofertilizer source because of their positive effects on plant growth and productivity They can help to reduce the amount of chemical fertilizers by up to 50% due to their ability in enhancing crops to uptake mineral nutrients efficently such as nitrogen, phosphorus, potassium, calcium, zinc. . . thereby increasing crop yield. Moreover, this endosymbiotic fungus also shows its potential as a biopesticide due to its ability to biologically antagonize a wide range of fungi, viruses, and nematodes, which cause diseases on plants. Besides, Arbuscular Mycorrhiza fungi also help plants to resist to abiotic streeses such as drought, salinity, and toxicity of heavy metals. The glomalin compound secreted by mycorrhizal fungi has the ability to bind tiny soil particles together to form a stable soil structure and aggregates, helping to improve soil qualitỵ Thus, Arbuscular Mycorrhiza fungi have a high use potential in sustainable agricultural development under the context of climate change such as drought, salinity intrusion

Effects of vermicompost on the growth and yield of spring onion (Allium fistulosum L.)

Spring onion (Allium fistulosum L.) is a popular salad vegetable produced widely over the world, including in Vietnam. Thanks to its flavor and aroma, it is an indispensable ingredient used to flavor soups and other dishes. Vermicompost is a natural and environmentally friendly fertilizer used widely to increase crop production and maintain the sustainability of agrosystems. Consequently, this study was conducted to investigate the efficiency of vermicompost at different application rates in promoting the growth and yield parameters of spring onion. The results show that adding vermicompost to spring onion production had significant positive effects on plant height, number of leaves, number of tillers, individual plant weight, and plot yield. Particularly, the application of vermicompost at 40 t ha-1 showed the highest performance in the observed parameters, increasing the number of leaves, number of tillers, individual plant weight, and plot yields to 64.78, 21.18, 302.96 g plant-1 , and 4.86 kg m-2 , respectively. The plot yields in the treatments of the highest and lowest vermicompost application increased by 49.1% and 3.9%, respectively, in comparison to the control. Consequently, there was a strongly positive relationship between the application rate of vermicompost and the plot yield

Using Bioinformatics to predict potential targets of Microrna-144 in osteoarthritis

MicroRNAs are short endogenous non-coding RNA molecules, typically 19-25 nucleotides in length, which negatively regulate gene expression through binding to 3’UTR of target mRNAs, leading to repression of protein translation or target mRNA degradation. MicroRNA-144 (miR-144) was found as an abnormal expression in various diseases, including osteoarthritis (OA). We have identified increased microRNA-144 expression in early phase and end stage of OA. However, the molecular mechanism of this increase has not been yet to be determined yet. Using bioinformatics tools, we found more than 4,000 mRNAs that are predicted to be potential direct targets of miR-144, including mRNAs involved in the critical signaling pathways in OA e.g. TGFβ/Smad2/3 and WNT/β-catenin. Results from this research provide information for future ex periments to validate miR-144 potential targets

Effect of the Cultivation Technology on the Yield of Paddy Straw Mushroom (Volvariella volvacea)

The edible paddy straw mushroom Volvariella volvacea (Bull. ex F.) Singer has high nutritional and medicinal values. They are grown on a wide variety of agricultural byproducts using different several methods. The result of this present study showed that type of bed and cultivation condition (outdoor/indoor) had effects on the yield of paddy straw mushrooms grown on the spent oyster mushroom sawdust. The treatment of circular compact bed under indoor cultivation condition (CYIC) had the best yield and biological efficiency (B.E.) with 2,119.2 g/bed and 14.5%, respectively, followed by the treatment of conventional bed under outdoor cultivation condition (COOC) with the yield and B.E. of 1,935.5 g/bed and 13.2%, respectively, but the lowest yield and B.E. were observed in the treatment of conventional bed under indoor cultivation condition (COIC) with 1,226.1 g/bed and 8.4%, respectively. Paddy straw mushrooms cultivated on spent oyster mushroom sawdust should be proper in both outdoor and indoor conditions by conventional and circular compact methods as well. However, in indoor conditions, paddy straw mushrooms should be grown in a circular compact bed to ensure the temperature of the bed is suitable for the mushroom growth

Association between ACE I/D genetic polymorphism and the severity of coronary artery disease in Vietnamese patients with acute myocardial infarction

BackgroundThe severity of coronary artery disease is a prognostic factor for major adverse cardiovascular events in patients diagnosed with acute myocardial infarction. ACE I/D polymorphism is one of the genetic factors that may affect the severity of coronary artery disease. This study aimed to investigate the association between ACE I/D genotypes and the severity of coronary artery disease in patients with acute myocardial infarction.Materials and methodsA single-center, prospective, observational study was conducted at the Department of Cardiology and Department of Interventional Cardiology, Cho Ray Hospital, Ho Chi Minh City, Vietnam from January 2020 to June 2021. All participants diagnosed with acute myocardial infarction underwent contrast-enhanced coronary angiography. The severity of coronary artery disease was determined by Gensini score. ACE I/D genotypes were identified in all subjects by using the polymerase chain reaction method.ResultsA total of 522 patients diagnosed with first acute myocardial infarction were recruited. The patients' median Gensini score was 34.3. The II, ID, and DD genotype rates of ACE I/D polymorphism were 48.9%, 36.4%, and 14.7%, respectively. After adjusting for confounding factors, multivariable linear regression analysis showed that the ACE DD genotype was independently associated with a higher Gensini score compared with the II or ID genotypes.ConclusionThe DD genotype of the ACE I/D polymorphism was associated with the severity of coronary artery disease in Vietnamese patients diagnosed with first acute myocardial infarction

Reliability and validity of the Vietnamese version of the Hamilton D-17 scale

BackgroundWhile depression is a common mental disorder, the diagnosis of this condition is still challenging. Thus, there is a need to have a validated tool to help evaluate symptoms of depression. This study aimed to evaluate the reliability and validity of the Vietnamese version of the Hamilton D-17 scale.MethodsA cross-sectional, descriptive, and validation study was conducted on 183 patients including 139 depressed and 44 non-depressed patients at the University Medical Center of Medicine and Pharmacy University at Ho Chi Minh City. Internal reliability and inter-rater reliability was measured using Cronbach's alpha and intraclass correlation coefficients (ICC). Confirmatory factor analysis (CFA) was used to evaluate construct validity. The Patient Health Questionnaire (PHQ9) was used to measure concurrent validity of the Hamilton D-17. Area under the ROC curve was used to measure criterion validity.ResultsBoth Cronbach alpha coefficient and ICC were at good level at alpha = 0.83 and ICC = 0.83. CFA with a second-order model consisting of four factors fitted the data at good to excellent level. The SRMR (Standardized Root Mean Squared Residual) was 0.066, RMSEA (Root Mean Square Error of Approximation) (90% CI) was 0.053 (0.036–0.069), CFI (comparative fit index) was 0.93, TLI (Tucker Lewis index) was 0.92. The Hamilton D-17 and the PHQ-9 had a correlation coefficient of r = 0.77 (p < 0.001). The Hamilton D-17 had a very high level of criterion validity with AUC of 0.93 (0.88–0.98).ConclusionThe Vietnamese version of the Hamilton D-17 scale has a high level of validity and reliability. The scale should be used to assess symptoms of depression among Vietnamese patients

Spatiotemporal evolution of SARS-CoV-2 Alpha and Delta variants during large nationwide outbreak of COVID-19, Vietnam, 2021

We analyzed 1,303 SARS-CoV-2 whole-genome sequences from Vietnam, and found the Alpha and Delta variants were responsible for a large nationwide outbreak of COVID-19 in 2021. The Delta variant was confined to the AY.57 lineage and caused >1.7 million infections and >32,000 deaths. Viral transmission was strongly affected by nonpharmaceutical interventions