Generalized sub band analysis and signal synthesis

The present paper introduces the basics of building a theory forsubband analysis/signal synthesis for various classes, and using transformations based on any orthonormal basis with weight.This proposed approach is based on the concept of Euclidean signal norm square fraction in a given subband of the transformant definition domain. It is shown that the basis for mathematical apparatus of subband analysis is a new class of matrices, called subband ones. Some eigenvalue properties of these matrices are established, and the problem of optimal selection for additive signal components is formulated and solve

RNA-binding activity of TRIM25 is mediated by its PRY/SPRY domain and is required for ubiquitination

Background TRIM25 is a novel RNA-binding protein and a member of the Tripartite Motif (TRIM) family of E3 ubiquitin ligases, which plays a pivotal role in the innate immune response. However, there is scarce knowledge about its RNA-related roles in cell biology. Furthermore, its RNA-binding domain has not been characterized. Results Here, we reveal that the RNA-binding activity of TRIM25 is mediated by its PRY/SPRY domain, which we postulate to be a novel RNA-binding domain. Using CLIP-seq and SILAC-based co-immunoprecipitation assays, we uncover TRIM25’s endogenous RNA targets and protein binding partners. We demonstrate that TRIM25 controls the levels of Zinc Finger Antiviral Protein (ZAP). Finally, we show that the RNA-binding activity of TRIM25 is important for its ubiquitin ligase activity towards itself (autoubiquitination) and its physiologically relevant target ZAP. Conclusions Our results suggest that many other proteins with the PRY/SPRY domain could have yet uncharacterized RNA-binding potential. Together, our data reveal new insights into the molecular roles and characteristics of RNA-binding E3 ubiquitin ligases and demonstrate that RNA could be an essential factor in their enzymatic activity

Smart Data Exchange

The problem of exchanging data, even considering incomplete and heterogeneous data, has been deeply investigated in the last years. The approaches proposed so far are quite rigid as they refer to fixed schema and/or are based on a deductive approach consisting in the use of a fixed set of (mapping) rules. In this paper we describe a smart data exchange framework integrating deductive and inductive techniques to obtain new knowledge. The use of graph-based representation of source and target data, together with the midway relational database and the extraction of new knowledge allow us to manage dynamic databases where also features of data may change over the time

Interactive methods of teaching foreign languages in higher education institutions

This study investigates how family lineage descent groups influence the intergenerational transmission of education for the cohorts of 1940-1989 in the Democratic Republic of Congo (DRC). The study applies both transition matrix and intergenerational persistence (IGP) methods, using the father's years of schooling as a proxy for parental education. The findings suggest a pronounced steady persistence in education for the estimated mean regression coefficient over a period of 49 years. Moreover, results by gender indicate that intergenerational persistence in education has significantly decreased for males in recent cohorts but slightly increased for females. Furthermore, findings suggest that intergenerational persistence has been decreasing in matrilineal descent groups in recent cohorts, while increasing for the patrilineal descent groups. The study gives a good sense of the relationship between family lineage descent and intergenerational transmission of education in DRC. In addition, it indicates that there is both substantial upward and downward intergenerational education mobility in the country.Nos últimos dez anos, o número de estudos sobre aeficácia das tecnologias e métodos interativos de ensino de línguas estrangeiras está em constante crescimento. Essa tendência se deve à disseminação da tecnologia no processo educacional e à necessidade dos alunos em utilizá-la devido à necessidade de adquirir habilidades de comunicação e conhecimento profissional de línguas estrangeiras. Todos os itens acima requerem o estudo das tendências modernas. A utilização de métodos interativos de ensino de línguas estrangeiras e a eficácia de métodos de ensino interativos é uma questão muito relevante. Este artigo sistematiza os tipos e efeitos das tecnologias interativas de ensino de línguas estrangeiras em instituições de ensino superior tendo como base um estudo de 76 publicações em 2010 -2020. Verificou-se que 63% dos estudos revelaram efeitos positivos do uso de tecnologias interativas. O maior efeito dos métodos interativos de ensino de línguas estrangeiras é observado na aprendizagem de palavras, aprendizagem integrada, leitura e fala. O artigo comprova o crescimento do nível de uso e do papel das tecnologias interativas para simplificar e facilitar as tarefas mais simples do processo educacional: tradução, pronúncia, interação. A abordagem didática para o ensino de línguas estrangeiras está mudando para umadiferenciada. O estudo mostrou que os efeitos positivos dos métodos interativos podem desaparecer com o tempo, à medida que os alunos perdem o interesse em uma nova tecnologia interativa que se torna uma ferramenta de aprendizagem. Para resolver este problema, os professores podem usar diferentes formas de estratégias inovadoras e habilidades de ensino. Eles podem integrá-los ao aprendizado usando a tecnologia.Este estudio investiga cómo los grupos de ascendencia de linaje familiar influyen en la transmisión intergeneracional de la educación para las cohortes de 1940-1989 en la República Democrática del Congo (RDC). El estudio aplica tanto la matriz de transición como los métodos de persistencia intergeneracional (IGP), utilizando los años de escolaridad del padre como un indicador de la educación de los padres. Los hallazgos sugieren una persistencia constante y pronunciada en la educación para el coeficiente de regresión medio estimado durante un período de 49 años. Además, los resultados por género indican que la persistencia intergeneracional en la educación ha disminuido significativamente para los hombres en las cohortes recientes, pero ha aumentadoligeramente para las mujeres. Además, los hallazgos sugieren que la persistencia intergeneracional ha disminuido en los grupos de descendencia matrilineal en las cohortes recientes, mientras que ha aumentado en los grupos de descendencia patrilineal. El estudio da una buena idea de la relación entre el linaje familiar y la transmisión intergeneracional de la educación en la República Democrática del Congo. Además, indica que existe una considerable movilidad educativa intergeneracional ascendente y descendente en el país