49 research outputs found

    Enantioselective Synthesis of (βˆ’)-Acetylapoaranotin

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    The first enantioselective total synthesis of the epipolythiodiketopiperazine (ETP) natural product (βˆ’)-acetylapoaranotin (3) is reported. The concise synthesis was enabled by an eight-step synthesis of a key cyclohexadienol-containing amino ester building block. The absolute stereochemistry of both amino ester building blocks used in the synthesis is set through catalytic asymmetric (1,3)-dipolar cycloaddition reactions. The formal syntheses of (βˆ’)-emethallicin E and (βˆ’)-haemotocin are also achieved through the preparation of a symmetric cyclohexadienol-containing diketopiperazine

    INHIBITION OF CARBOXYDISMUTASE BY IODOACETAMIDE

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    THE MECHANISM OF ACTION OF CARBOXYDISMUTASE

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