29 research outputs found
Preliminary dragonfly (Odonata) species list from the Pampa biome in Rio Grande do Sul, Brazil, with ecological notes for 19 new records for the State
Full text linkSynthesis of (−)-Dactylolide and 13-Desmethylene-(−)-dactylolide and Their Effects on Tubulin
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Isoform-selective ATAD2 chemical probe with novel chemical structure and unusual mode of action
No full textATAD2 (ANCCA) is an epigenetic regulator and transcriptional cofactor, whose overexpression has been linked to the progress of various cancer types. Here, we report a DNA-encoded library screen leading to the discovery of BAY-850, a potent and isoform selective inhibitor that specifically induces ATAD2 bromodomain dimerization and prevents interactions with acetylated histones in vitro, as well as with chromatin in cells. These features qualify BAY-850 as a chemical probe to explore ATAD2 biology
Who is Part of the Environmental Movement? Assessing Network Linkages between NGOs and Corporations
No full textMetabolic profiling in Caenorhabditis elegans provides an unbiased approach to investigations of dosage dependent lead toxicity
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