A Preliminary Study on Histological Effect of Salted Fish (Ophiocephalus Striata) in Albino Rats

Tiga puluh ekor tikus putih umur 28 hari dibagi menjadi 3 kelompok. Setiap kelom­pok terdiri atas 10 ekor. Grup I diberi makan pakan non-protein, Grup II diberi pakan 10% susu skim dan Grup III diberi pakan 10% protein ikan asin. Makanan dan minuman diberikan secara ad. libitum. Setiap ekor sebelum percobaan dimulai dan 2 kali seminggu selama masa observasi ditimbang berat badannya. Pada hari ke 28, setiap tikus diukur protein efficiency rationya. Percobaan ini diamati selama 4 bulan penuh. Dalam masa observasi, ditemukan 3 ekor tikus Grup III mati dan 2 ekor tampak kurus serta bulunya kasar dan tidak berkilau. Pada otopsi dari tikus yang mati ditemukan mukosa bagian posterior orofaring berwarna keputihan dan permukaannya bergranuler. Pada pemeriksa­an mikroskopik jaringan ini menunjukkan reaksi radang kronis dan disertai dengan hiperplasi dan hiperkeratosis lapisan mukosa. Lapisan epitel beberapa asinus kelenjar ludah mengalami skuamus metaplasia dan ada pula yang disertai mutiara keratin. Ada beberapa lagi asinus yang mengalami delatasi dan lumennya dilapisi epitel gepeng. Alat-alat tubuh lain tidak mengalami Perubahan yang nyata

Association between Hscrp Levels and Glycemic Control with Total Interatrial Conduction Time in Type 2 Diabetes Mellitus Patients

BACKGROUND: Type 2 Diabetes Mellitus (T2DM) represents one of the most important risk factors for atrial fibrillation (AF). Numerous studies have shown that T2DM and poor glycemic control reflected by glycated hemoglobin A1c (HbA1c) levels are independently associated with AF onset. Recent experimental studies reported that the increased susceptibi-lity to AF in the diabetic patients was presumably due to the slowing con-duction associated with increased interstitial fibrosis. Systemic inflame-mation can play role in the development of atrial fibrillation. High-sensitivity C-reactive protein (HsCRP) is an inflammatory biomarker that independently predicts the cardiovascular risk. This study aimed to analy-ze the association between HsCRP level, glycemic control, and total intera-trial conduction time in T2DM patients. SUBJECT AND METHODS: This was an analytic cross sectional study. A total of 41 patients with T2DM were evaluated. HsCRP and HbA1c were measured from peripheral venous blood samples taken from these patients. The total interatrial conduction time was measured by tissue Doppler echocardiography. Multiple regression analysis was use to analyzed the data. RESULTS: The high-sensitivity C-reactive protein level was higher in the T2DM patients with HbA1c≥7% (0.44±0.30) than in the T2DM patients with HbA1c<7% (0.32±0.22), although statistically non-significant (p=0.183). The total atrial conduction time (milliseconds) was longer in the T2DM patients with HbA1c≥7% (100.29±28.53) than in T2DM patients with HbA1c<7% (94.88±16.50), although statistically non-signifi-cant (p=0.449). Multiple regression analysis showed that HsCRP level (b=38.78; 95%CI=14.01 to 63.54; p=0.003) and glycemic control (b=14.04; 95%CI=0.09 to 27.98; p=0.048) had positive association with total interatrial conduction time in T2DM patients. CONCLUSION: HsCRP level and glycemic control had significant positive association with total interatrial conduction time in T2DM patients. Keywords: HsCRP, glycemic control, HbA1c, total interatrial conduction time

The Effect of Colchicine Administration on HsCRP Level and Mean Platelet Volume in Patients with Miocard Acute Infark

Background: Patients with coronary heart disease (CHD) who have received standard therapy to the fullest, are still at risk for further cardiovascular events. This is likely because the standard therapy fails to inhibit some inflammatory pathways and platelet aggregation which implies the disease. This study aimed to determine the effect of colchicine on reducing levels of high sensitive c-reactive protein (HsCRP) and mean platelet volume (MPV) in patients with Acute Myocardial Infarction (IMA) in the Intensive Cardiovascular Unit (ICVCU) Dr. Moewardi Hospital, Surakarta.Subjects and Method: Experimental study was conducted with pre and post design. The study was conducted from November 1 to December 31, 2016. A sample of 32 patients with Acute Myocardial Infarction was divided into two groups. The control group was given a placebo and the treatment group was given colchicine 0.5 mg orally for 5 days. Statistical analysis was done using two mean different tests with dependent t-test or Mann-Whitney and two mean analysis paired using independent t-test or Wilcoxon.Results: The HsCRP delta level in colchicine group (mean = 3.82; SD = 2.20) was higher than control group (mean = 0.57; SD = 3.12) and it was statistically significant (p<0.001). The delta MPV levels in colchicine group (mean = 2.01; SD = 1.16) were higher than control group (mean = 0.64; SD = 0.83) and it was statistically significant (p = 0.001).Conclusion: The administration of 0.5 mg colchicine by oral for 5 days was associated with levels of HsCRP and MPV among IMA patients. Keywords: Colchicine, HsCRP, MPV, Acute Myocardial InfarctionCorrespondence: Trisulo Wasyanto. Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Sebelas Maret. Jl. Ir. Sutami 36A, Surakarta57126, Central Java, Indonesia. Email: [email protected] Journal of Medicine (2018), 152-157https://doi.org/10.26911/theijmed.2018.03.03.0

Association Between Left Ventricular Global Longitudinal Strain and Functional Capacity Measured with Six-Minutes Walk Test in Patients After Acute Myocardial Infarction.

Background: The ischemia resulting from critical coronary narrowing or total occlusion first affects the subendocardialmyofibers. Thus, abnormalities in longitudinal function can be detected before reductions in LVEF and reflects infarct size. The 6MWT provides information that may be a better index of the patients ability to perform daily activities. This study was to assess the relationship between left ventricular (LV) global longitudinal strain (GLS) and functional capacity measured with 6 minute walk test (6MWT) after AMI.Subjects and Method: This is a cross sectional study of patients with STEMI and NSTEMI, at Moewardi Hospital, Surakarta. Eligible patients underwent echocardiography global longitudinal 2D-STE that performed within 48 hour of admission and 6MWT pre- discharge or at the first follow-up visits (day 4-9). Patients were divided into 2 groups according to the LV GLS value, patients with substantial infarction (LV GLS > -13.8%) and non-substantial infarction (LV GLS -13.8% (n=32) were more likely to be older (57.6 y.ovs 55 y.o), less in functional capacity (10.17 1.3 ml/kg/min vs 11.04 0.98 ml/kg/min; p= 0.018) and less in 6 MWT distance (347.97 65.49 m vs392.39 49.44 m; p=0.016). Using ROC curves, the 6 MWT distance cutoff value of 375 m identified patients with LV GLS >-13.8%, sensitivity of 72.2% and specificity 65.6%, respectively with AUC= 0.70 (CI 95%; 0.559-0.852; p= 0.017). However, LV GLS >-13.8% and age >60 y.o remained the independent predictor in a multivariate logistic regression analysis to identify 6 MWT distance -13.8%, (OR =7.967; CI 95%= 1.669-38.030; p=0.009) and age >60 y.o, (OR=10.898; CI95%= 2.201-53.971; p=0.003).Conclusions: In patients after AMI with substantial infarction (LV GLS >-13.8%) had less in functional capacity. The 6 MWT distance cutoff value of 375 m identified patients with LV GLS >-13.8% and could be used in rehabilitation program after AMI.Keywords: Acute Myocardial Infarction, LV Global longitudinal strain, functional capacity, 6 MWT.Correspondence:Trisulo Wasyanto. Department of Cardiology and Vascular Medicine, Faculty of Medicine, Masters Program in Public Health, Universitas Sebelas Maret. Jl. Ir. Sutami No. 36 A, 57126, Surakarta, Central Java.Indonesian Journal of Medicine (2017), 2(3): 192-206https://doi.org/10.26911/theijmed.2017.02.03.0