A REVIEW ON THE SIGNIFICANCE OF NITYA VIRECHANA IN THE MANAGEMENT OF JALODARA (ASCITES)

Jalodara is a type of Udara roga. It is such type of a disease which is difficult to cure. Its occurrence is increasing day by day in our society. In Jalodara, there is accumulation of fluid in between Tvak and Mamsa of Udara pradesha (abdomen). As a result, there is distension of abdomen. Its main causes are Mandagni, Srota avarodha and Apa dosha etc. Here vitiated Kapha and Vata are mainly involved. In this disease accumulated Doshas are mainly obstruct the Swedavaha and Ambuvaha srotas. It has three stages which are Ajatodakavastha, Picchavastha and Jatodakavastha. Jalodara in its Jatodakavastha is incurable. It can be correlated with Ascites based on its clinical features. Ascites is the abnormal accumulation of free fluid in the peritoneal cavity. Its most common cause is portal hypertension related to hepatic cirrhosis. Ascites is asymptomatic when there is small accumulation of fluid in peritoneal cavity. But when there is larger accumulation of fluid (> 1 lit), it shows symptoms. In this article, Ayurvedic treatment principles for Jalodara have been discussed in details. These include Nidan parivarjana, Nitya virechana, therapies which remove the defects of liquid elements (Apam doshaharanam), Dipana and Shastra karma (abdominal tapping). This article is mainly based on the review of the significance of Nitya virechana in the management of Jalodara (Ascites)

MANAS (MIND) AND MANOVIKARA (MENTAL DISORDER) IN AYURVEDA: A REVIEW

Ayurveda is thought to be ‘The Science of Life’, and therefore the follow involves the care of physical and mental health of creature. Ayurveda isn’t solely restricted to body or physical symptoms however conjointly provide comprehensive data concerning mental and social health. Three factors are basically responsible for the origin of any kind of disease, these are Asatmaindriyartha Samyoga (excessive utilization or non-utilization or improper utilization of sense faculties), Prajnaparadha (Intellectual blasphemy) and Parinama (time). Balanced Doshas of mind regulates the emotion while disturbed Doshas of mind plays an important role in the pathogenesis of mental diseases. The increasing level of stress in today’s time gives a huge surge of Manovikara (mental disorder). In Ayurveda many references of Manas (mind) and treatment of Manovikara (mental disorder) are available which would be easy to understand and rewarding the field of treatment. Role of Swastavritta including Daivavyapasraya, Satwavajay, Naisthiki chikitsa and Yoga are very important in the management of Manovikara. In modern era we are at the grasp of Raja and Tama which are the root cause of mental disorder. So, it is necessary to understand the Manovikara (mental disorder), its causes, symptoms, prevention and management. Present article is a review article contains review of Manas (Mind) and Manovikara (Mental disorder) in Ayurveda

A Comparative Clinical Evaluation on the Efficacy of Kuberaksha & Yava with Lifestyle Modification, in The Management of Prameha with Special Reference to Prediabetes

We are living in the age of complexity, contradiction, and challenge relating to various health issues such as lifestyle disorder, ageing, mental health euthanasia, drug resistance and so on. Diabetes Mellitus is a Giant disease and major health issue that has reached alarming level in spite of terrific advance in modern medical science. Prediabetes is the precursor stage before Diabetes Mellitus, in which not all of the symptoms required to diagnose diabetes are present, but blood sugar is abnormally high. Prediabetic persons are considered to be at increased risk for the subsequent development Diabetes Mellitus. Sushruta Samhita mentioned, all varieties of Prameha if not treated at appropriate time, become changed to Madhumeha which is incurable. So, early detection, treatment and prevention of this disease in Prediabetic stage is needed. The modification of lifestyle should be the first aim and objectives to restrict or combat such problems, beside this prime objective, some medication which is safe and efficacious to be introduced. So, a clinical study with 60 patients has been conducted on Prediabetes through the management with ‘Kuberaksha’ and ‘Yava’ in such 2 groups of treatment. The two drugs are carrying such properties which acts in Samprapti vighatana (prevent pathogenesis) of the disease. In both cases statistically significant results are found (P<0.001 & <0.01). On comparison between two groups Kuberaksha powder showed better result than Yava powder

P38δ genetic ablation protects female mice from anthracycline cardiotoxicity

© 2020 the American Physiological Society. The efficacy of an anthracycline antibiotic doxorubicin (DOX) as a chemotherapeutic agent is limited by dose-dependent cardiotoxicity. DOX is associated with activation of intracellular stress signaling pathways including p38 MAPKs. While previous studies have implicated p38 MAPK signaling in DOXinduced cardiac injury, the roles of the individual p38 isoforms, specifically, of the alternative isoforms p38γ and p38δ, remain uncharacterized. We aimed to determine the potential cardioprotective effects of p38γ and p38δ genetic deletion in mice subjected to acute DOX treatment. Male and female wild-type (WT), p38γ-/-, p38δ-/-, and p38γ-/-δ-/- mice were injected with 30 mg/kg DOX and their survival was tracked for 10 days. During this period, cardiac function was assessed by echocardiography and electrocardiography and fibrosis by Picro Sirius Red staining. Immunoblotting was performed to assess the expression of signaling proteins and markers linked to autophagy. Significantly improved survival was observed in p38δ-/- female mice post-DOX relative to WT females, but not in p38γ-/- or p38γ-/-δ-/- male or female mice. The improved survival in DOX-treated p38δ-/- females was associated with decreased fibrosis, increased cardiac output and LV diameter relative to DOXtreated WT females, and similar to saline-treated controls. Structural and echocardiographic parameters were either unchanged or worsened in all other groups. Increased autophagy, as suggested by increased LC3-II level, and decreased mammalian target of rapamycin activation was also observed in DOX-treated p38δ-/- females. p38δ plays a crucial role in promoting DOX-induced cardiotoxicity in female mice by inhibiting autophagy. Therefore, p38δ targeting could be a potential cardioprotective strategy in anthracycline chemotherapy. New & Noteworthy: This study for the first time identifies the sex-specific roles of the alternative p38γ and p38δ MAPK isoforms in promoting doxorubicin (DOX) cardiotoxicity. We show that p38δ and p38γ/δ systemic deletion was cardioprotective in female but not in male mice. Cardiac structure and function were preserved in DOXtreated p38δ-/- females and autophagy marker was increased