5,381 research outputs found
A Value-Based Approach for Sustainable Supplier-Customer Relationships: The Case of the Indian Steel Industry
The steel industry, which has endured years of mediocre performance due to a supply glut and consequent depressed world prices, has seen considerable resurgence during the last several months. The ever-widening demand-supply gap, and greatly increased input costs have resulted in prices firming up. The sharp increase in steel prices without any let-up is an issue that steel customers have found difficult to grapple with. Many customers believe that the steel industry is behaving opportunistically. The paper attempts to understand the dynamics of the Indian steel industry. Although the steel industry caters to both consumer (B2C) and business (B2B) markets, the focus of the paper is on the business markets, which accounts for 80% of the market. After presenting a picture of who the suppliers and customers of the steel industry are, the paper presents the various forces at play in the industry, a conceptual model to understand supplier-customer relationships in the industry, and traces the sources of animosity and hostility between the supplier and the customer firms. Forging meaningful value-based long-term relationships between supplier and customer firms as a way forward is explored. The paper presents possible remedies to the malady of distrust between customer and supplier firms. Collaborative working between competing suppliers and active pan-industry collaborative forums to bring better cooperation and trust between customer and supplier firms are essential first steps to bring normalcy back into the industry’s functioning.
Electric vehicle battery performance investigation based on real world current harmonics
Electric vehicle (EV) powertrains consist of power electronic components as well as electric machines to manage the energy flow between different powertrain subsystems and to deliver the necessary torque and power requirements at the wheels. These power subsystems can generate undesired electrical harmonics on the direct current (DC) bus of the powertrain. This may lead to the on-board battery being subjected to DC current superposed with undesirable high- and low- frequency current oscillations, known as ripples. From real-world measurements, significant current harmonics perturbations within the range of 50 Hz to 4 kHz have been observed on the high voltage DC bus of the EV. In the limited literature, investigations into the impact of these harmonics on the degradation of battery systems have been conducted. In these studies, the battery systems were supplied by superposed current signals i.e., DC superposed by a single frequency alternating current (AC). None of these studies considered applying the entire spectrum of the ripple current measured in the real-world scenario, which is focused on in this research. The preliminary results indicate that there is no difference concerning capacity fade or impedance rise between the cells subjected to just DC current and those subjected additionally to a superposed AC ripple current
Prolonged survival of patients receiving trastuzumab beyond disease progression for HER2 overexpressing metastatic breast cancer (MBC)
Background: The aim of this retrospective analysis was to evaluate the impact of trastuzumab-based regimens on the survival of patients with HER2-overexpressing metastatic breast cancer (MBC). The study specifically focussed on the influence of the continuation of trastuzumab-based treatment despite tumor progression on survival. Patients and Methods: Patients with HER2 overexpressing MBC were included in this retrospective analysis. HER2 overexpression was determined by the immunohistochemical staining score (DAKO Hercep Test (TM)). Trastuzumab was applied at a loading dose of 4 mg/kg and a maintenance dose of 2 mg/kg. Results: Among 136 HER2 overexpressing patients (DAKO score 3+), 66 patients received first-line trastuzumab, 47 patients received trastuzumab as second-line therapy and 23 patients received trastuzumab beyond disease progression. There was no significant difference regarding the duration of trastuzumab-based treatment (first-line: 29.5 weeks vs. second-line: 25 weeks). Moreover, there was no difference in the response rate (first-line: 37.9% vs. second-line: 35.7%) or the median survival (p = 0.47 log rank). Patients who received >= 2 trastuzumab-based regimens for MBC survived significantly longer compared to those who had received only 1 regimen (>= 2 regimens: 62.4 months vs. 1 regimen: 38.5 months; p = 0.01 log rank). Conclusions: Trastuzumab is highly effective in the treatment of HER2 overexpressing MBC. Compared to historical controls, overall survival appears to be markedly prolonged, particularly in patients who received sequential trastuzumab-based treatment beyond disease progression
Mechanism of enhanced light output in InGaN-based microlight emitting diodes
Micro-light emitting diode (LED) arrays with diameters of 4 to 20 mum have been fabricated and were found to be much more efficient light emitters compared to their broad-area counterparts, with up to five times enhancement in optical power densities. The possible mechanisms responsible for the improvement in performance were investigated. Strain relaxation in the microstructures as measured by Raman spectroscopy was not observed, arguing against theories of an increase in internal quantum efficiency due to a reduction of the piezoelectric field put forward by other groups. Optical microscope images show intense light emission at the periphery of the devices, as a result of light scattering off the etched sidewalls. This increases the extraction efficiency relative to broad area devices and boosts the forward optical output. In addition, spectra of the forward emitted light reveal the presence of resonant cavity modes [whispering gallery (WG) modes in particular] which appear to play a role in enhancing the optical output
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