THREE PHASE GRID-CONNECTED PHOTOVOLTAIC UNIVERSAL BRIDGE INVERTER APPLYING A BOOST CONVERTER

In this paper, a three phase grid connected universal bridge inverter using a boost converter is suggested for photovoltaic (PV) systems and grid connected systems to improve performance of three phase inverter connected to the grid. The PV grid system has a disadvantage that the output voltage of PV array is low and we need to boost then in order to efficiently convert them into alternating voltage. The boost inductor boosts the output of the PV array to a suitable level so that inverter could convert it into alternating form. The DC/AC inverter is most important part of the PV system

DEVELOPMENT OF HINT BASED COMPUTATIONAL TOOLS FOR DRUG DESIGN: APPLICATIONS IN THE DESIGN AND DEVELOPMENT OF NOVEL ANTI-CANCER AGENTS

The overall aim of the research is to develop a computational platform based on HINT paradigm for manipulating, predicting and analyzing biomacromolecular-ligand structure. A second synergistic goal is to apply the above methodology to design novel and potent anti-cancer agents. The crucial role of the microtubule in cell division has identified tubulin as an interesting target for the development of therapeutics for cancer. Pyrrole-containing molecules derived from nature have proven to be particularly useful as lead compounds for drug development. We have designed and developed a series of substituted pyrroles that inhibit growth and promote death of breast tumor cells at nM and μM concentrations in human breast tumor cell lines. In another project, stilbene analogs were designed and developed as microtubule depolymerizing agents that showed anti-leukemic activity. A molecular modeling study was carried out to accurately represent the complex structure and the binding mode of a new class of tubulin inhibitors that bind at the αβ-tubulin colchicine site. These studies coupled with HINT interaction analyses were able to describe the complex structure and the binding modes of inhibitors. Qualitative analyses of the results showed general agreement with the experimental in vitro biological activity for these derivatives. Consequently, we have been designing new analogs that can be synthesized and tested; we believe that these molecules will be highly selective against cancer cells with minimal toxicity to the host tissue. Another goal of our research is to develop computational tools for drug design. The development and implementation of a novel cavity detection algorithm is also reported and discussed. The algorithm named VICE (Vectorial Identification of Cavity Extents) utilizes HINT toolkit functions to identify and delineate a binding pocket in a protein. The program is based on geometric criteria and applies simple integer grid maps to delineate binding sites. The algorithm was extensively tested on a diverse set of proteins and detects binding pockets of different shapes and sizes. The study also implemented the computational titration algorithm to understand the complexity of ligand binding and protonation state in the active site of HIV-1 protease. The Computational titration algorithm is a powerful tool for understanding ligand binding in a complex biochemical environment and allows generating hypothesis on the best model for binding

The Nature of the IMBH Candidate CXO~J133815.6+043255: High-Frequency Radio Emission

The ultra-luminous X-ray source CXO~J133815.6+043255 is a strong candidate for a bona-fide intermediate mass black hole, residing in the outskirts of NGC~5252. We present 22~GHz radio observations of this source obtained serendipitously in an ongoing high-frequency imaging survey of radio-quiet Active Galactic Nuclei (AGN), and use this new data point to construct the broad-band radio spectral energy distribution (SED). We find that the SED exhibits a spectral slope of $\alpha=-0.66\pm0.02$, consistent with a steep spectrum from optically-thin synchrotron emission from an unresolved jet. We also find that the $L_R / L_X$ ratio is approximately $10^{-3}$, inconsistent with radio-quiet AGN and many ULXs but consistent with low-luminosity AGN (LLAGN) and radio-loud quasars. Together, these observations support the conclusion that CXO~J133815.6+043255 is an intermediate-mass black hole producing a low-mass analog of radio jets seen in classical quasars.Comment: 8 pages, 3 figures, accepted for publication in the Astrophysical Journa

Dysregulation of Complement System in Neuropsychiatric Disorders: A Mini Review

Complement system is one of the most important defense mechanisms of the innate immune system. In addition to their roles in immune regulation, complement proteins are also involved in neurodevelopment and adult brain plasticity. Complement dysregulation has been shown in neurodevelopmental disorders including schizophrenia and autism spectrum disorder as well as in mood disorders. A number of clinical as well as genetic studies suggest the role of complement proteins in the cortical thinning and excessive synaptic pruning frequently associated with schizophrenia. The changes in complement proteins are also associated with the pathophysiology of autism spectrum disorder, major depressive disorder and bipolar disorder, but warrant further research. In addition, rodent models suggest a strong case for complement system in anxiety-like behavior. In this article, we review the recent findings on the role of complement system in neuropsychiatric disorders. The possible uses for future complement targeted therapies are also discussed

Pimavanserin Treatment Increases Plasma Brain-Derived Neurotrophic Factor Levels in Rats

BACKGROUND: Pimavanserin, a serotonin 5HT-2A receptor inverse agonist is the first-line, FDA-approved treatment of hallucinations and delusions associated with Parkinson\u27s Disease psychosis (PDP), which occurs in up to 50% of PD patients. The neurobiological mechanism underlying the therapeutic effectiveness of Pimavanserin in PDP remains unknown. Several earlier studies have shown that treatment with 5HT-2A antagonists and other drugs acting on the serotonergic system such as SSRIs increase Brain derived neurotrophic factor (BDNF) levels in rodents. BDNF is synthesized as the precursor proBDNF, that undergoes cleavage intra or extracellularly to produce a mature BDNF (mBDNF) protein. mBDNF is believed to play a key role in neuroplasticity and neurogenesis. The present study tested the hypothesis that treatment with Pimavanserin is associated with higher and sustained elevations of mBDNF. METHODS: Adult Sprague-Dawley male rats were treated with Pimavanserin, Fluoxetine or vehicle for 4 weeks (chronic) or 2 h (acute). BDNF levels were determined by enzyme-linked Immunosorbent assay (ELISA). RESULTS: We found significant increases in plasma mBDNF levels in rats following chronic Pimavanserin treatment, but not in Fluoxetine-treated rats. No significant changes in mBDNF levels were found in the prefrontal cortex or hippocampus following Pimavanserin or Fluoxetine treatment. CONCLUSION: These findings suggest that increase in mBDNF levels could be a contributing mechanism for the neuroprotective potential of Pimavanserin

Detection of a quasi-periodic oscillation in gamma-ray light curve of the high redshift blazar B2 1520+31

We detected a possible quasi-periodic oscillation (QPO) of ~ 71 days in the 0.1 -- 300 GeV gamma-ray Fermi-LAT light curve of the high redshift flat spectrum radio quasar B2 1520+31. We identify and confirm that quasi-period by Lomb Scargle periodogram (LSP), and weighted wavelet z-transform (WWZ) analyses. Using this QPO period, and assuming it originates from accretion-disc fluctuations at the innermost stable circular orbit, we estimate the central supermassive black hole mass to range between ~ 5.4 * 10$^{9}$ M$_{\odot}$ for a non-rotating black hole and ~ 6.0 * 10$^{10}$ M$_{\odot}$ for a maximally rotating black hole. We briefly discuss other possible radio-loud active galactic nuclei emission models capable of producing a gamma-ray QPO of such a period in a blazar.Comment: 6 pages, 4 figures, Submitted to MNRA