Automated Analysis of Stateful Feature Models

In CAiSE 2005, we interpreted the extraction of relevant information from extended feature models as an automated reasoning problem based on constraint programming. Such extraction is driven by a catalogue of basic and compound operations. Much has been done since, renaming the problem as the automated analysis of feature models, a widely accepted problem in the Software Product Line (SPL) community. In this chapter, we review this seminal contribution and its impact in the community, highlighting the key milestones up to a more complete problem formulation that we coin as the Automated Analysis of Stateful Feature Models (AASFM). Finally, we envision some breakthroughs and challenges in the AASFM.Ministerio de Ciencia e Innovación TIN2009- 07366Junta de Andalucía TIC-590

Included, but Deportable: A New Public Health Approach to Policies That Criminalize and Integrate Immigrants.

There has been a burst of research on immigrant health in the United States and an increasing attention to the broad range of state and local policies that are social determinants of immigrant health. Many of these policies criminalize immigrants by regulating the "legality" of their day-to-day lives while others function to integrate immigrants through expanded rights and eligibility for health care, social services, and other resources.Research on the health impact of policies has primarily focused on the extremes of either criminalization or integration. Most immigrants in the United States, however, live in states that possess a combination of both criminalizing and integrating policies, resulting in distinct contexts that may influence their well-being.We present data describing the variations in criminalization and integration policies across states and provide a framework that identifies distinct but concurrent mechanisms of deportability and inclusion that can influence health. Future public health research and practice should address the ongoing dynamics created by both criminalization and integration policies as these likely exacerbate health inequities by citizenship status, race/ethnicity, and other social hierarchies

Multiple Sources toward the High-mass Young Star S140 IRS1

S140 IRS1 is a remarkable source where the radio source at the center of the main bipolar molecular outflow in the region is elongated perpendicular to the axis of the outflow, an orientation opposite to that expected if the radio source is a thermal jet exciting the outflow. We present results of 1.3 cm continuum and H2O maser emission observations made with the VLA in its A configuration toward this region. In addition, we also present results of continuum observations at 7 mm and re-analyse observations at 2, 3.5 and 6 cm (previously published). IRS 1A is detected at all wavelengths, showing an elongated structure. Three water maser spots are detected along the major axis of the radio source IRS 1A. We have also detected a new continuum source at 3.5 cm (IRS 1C) located ~0.6'' northeast of IRS 1A. The presence of these two YSOs (IRS 1A and 1C) could explain the existence of the two bipolar molecular outflows observed in the region. In addition, we have also detected three continuum clumps (IRS 1B, 1D and 1E) located along the major axis of IRS 1A. We discuss two possible models to explain the nature of IRS 1A: a thermal jet and an equatorial wind.Comment: 17 pages, 4 figures, to be published in A

National Pride of the Filipino Youth

The main purpose of this study was to know how proud the youth are of being a Filipino. Socio-demographic characteristics also play a role in determining the national pride of Filipino youth. The level of pride similarly varied among domain-specific aspects. We used a structured survey questionnaire adopted and modified from the International Social Survey Programme from their National Identity study. For this study, a four-stage sampling was observed to get the sample. Sports was the top source of the Filipino youth's national pride, among the 12 domain-specific aspects. However, Politics and Democracy got the lowest level of national pride. Differences among sexes significantly varied in the aspect of Sports, Economy and Social Security, and Environment. Pride in Arts and Literature, Sports, Armed Forces, and History differ among religions. The difference in Educational Attainment affects the level of national pride of the youth in the aspect of Fair and Equal Treatment in All Groups. Moreover, the socio-demographic characteristics play a role in determining the national pride of the Filipino youth. The study used quantitative research approach, specifically descriptive. A self-administered survey was distributed to 400 randomly selected youth respondents of 15-29 years old in the National Capital Region, Philippines

Thioredoxin Profiling of Multiple Thioredoxin-Like Proteins in Staphylococcus aureus

Hydrogen sulfide (H2S) is thought to signal through protein S-sulfuration (persulfidation; S-sulfhydration) in both mammalian systems and bacteria. We previously profiled proteome S-sulfuration in Staphylococcus aureus (S. aureus) and identified two thioredoxin-like proteins, designated TrxP and TrxQ, that were capable of reducing protein persulfides as a potential regulatory mechanism. In this study, we further characterize TrxP, TrxQ and the canonical thioredoxin, TrxA, by identifying candidate protein substrates in S. aureus cells using a mechanism-based profiling assay where we trap mixed disulfides that exist between the attacking cysteine of a FLAG-tagged Trx and a persulfidated cysteine on the candidate substrate protein in cells. Largely non-overlapping sets of four, 32 and three candidate cellular substrates were detected for TrxA, TrxP, and TrxQ, respectively, many of which were previously identified as global proteome S-sulfuration targets including for example, pyruvate kinase, PykA. Both TrxA (kcat = 0.13 s-1) and TrxP (kcat = 0.088 s-1) are capable of reducing protein persulfides on PykA, a model substrate detected as a candidate substrate of TrxP; in contrast, TrxQ shows lower activity (kcat = 0.015 s-1). This work reveals that protein S-sulfuration, central to H2S and reactive sulfur species (RSS) signaling, may impact cellular activities and appears to be regulated in S. aureus largely by TrxP under conditions of sulfide stress

La evolución climática a largo plazo y evaluación de la seguridad

El concepto de almacenamiento geológico profundo para residuos radiactivos de alta actividad basa una parte importante de su seguridad a largo plazo en el comportamiento del medio geológico. De aquí que los estudios de seguridad post-clausura de tales almacenamientos deban contemplar la necesidad de cuantificar los procesos susceptibles de intervenir en la liberación y el transporte de los radionucleidos desde el propio almacenamiento hasta la biosfera, y las modificaciones importantes que esta última pueda sufrir debido tanto a factores naturales como antropogénicos, durante los periodos de tiempo del orden de cientos de miles de años en que se cifra la duración de la liberación de radionucleido

Widespread Protein Aggregation as an Inherent Part of Aging in C. elegans

Several hundred proteins become insoluble and aggregation-prone as a consequence of aging in Caenorhabditis elegans. The data indicate that these proteins influence disease-related protein aggregation and toxicity

Cardiovascular disease behavioral risk factors among Latinos by citizenship and documentation status.

BACKGROUND:Studies have observed that recent Latino immigrants tend to have a physical health advantage compared to immigrants who have been in the US for many years or Latinos who are born in the United States. An explanation of this phenomenon is that recent immigrants have positive health behaviors that protect them from chronic disease risk. This study aims to determine if trends in positive cardiovascular disease (CVD) risk behaviors extend to Latino immigrants in California according to citizenship and documentation status. METHODS:We examined CVD behavioral risk factors by citizenship/documentation statuses among Latinos and non-Latino US-born whites in the 2011-2015 waves of the California Health Interview Survey. Adjusted multivariable logistic regressions estimated the odds for CVD behavioral risk factors, and analyses were stratified by sex. RESULTS:In adjusted analyses, using US-born Latinos as the reference group, undocumented Latino immigrants had the lowest odds of current smoking, binge drinking, and frequency of fast food consumption. There were no differences across the groups for fruit/vegetable intake and walking for leisure. Among those with high blood pressure, undocumented immigrants were least likely to be on medication. Undocumented immigrant women had better patterns of CVD behavioral risk factors on some measures compared with other Latino citizenship and documentation groups. CONCLUSIONS:This study observes that the healthy Latino immigrant advantage seems to apply to undocumented female immigrants, but it does not necessarily extend to undocumented male immigrants who had similar behavioral risk profiles to US-born Latinos