Designing integrated teaching project for argumentative texts in 11th grade philology curriculum

In the 2018 high school education program, integrated teaching is defined as an approach of developing curriculum, contents and teaching methods. The construction of integrated teaching themes in the Philology curriculum at high schools needs to fulfill the requirements to organize, connect the learning contents towards reality, creating opportunities for students to conduct practical studies, experience and navigate their future careers as well as to improve their overall capacities. This article illustrates ideas and results for designing integrated teaching themes for augmentative texts in the 11th grade Philology curriculum and the tentative plan for implementation of these themes with project-based learning method and portfolio assessment. This paper, meanwhile, handles multiple educational contents in the current 11th Grade Philology textbook and aims to a new lesson plan design in accordance with the 2018 Philology curriculum

EVALUATION OF ACUTE AND SUB-ACUTE ORAL TOXICITY OF CLINACANTHUS NUTANS LEAVES EXTRACT IN MICE

Objective: This study aimed to evaluate acute and sub-acute oral toxicity of ethanol extract of Clinacanthus nutans leaves in Swiss mice. Methods: Acute oral toxicity study was performed as per OECD-423 guidelines. Sub-acute oral toxicity study was performed as per OECD-407 guidelines. The extract was dissolved in 10% dimethyl sulfoxide and administered orally, while the control group received only the vehicle. Results: The acute oral toxicity test on mice showed that this extract was well tolerated up to LD50 5000 mg/kg body weight/day oral dosage level and non-toxic to mice under the present experimental conditions. The sub-acute toxicity study was carried out on mice with the oral dosage of the extract from 100 mg/kg–500 mg/kg body weight/day and 5000 mg/kg body weight/day for 28 d. The results showed that this extract did not induce death or adverse effects in activity, feed consumption or body weight gain. There were not significant changes in heamotological and biochemical parameters between control and experiment groups. Conclusion: Thus, Clinacanthus nutans leaf has a very low toxicity value

THE AMOUNT AND SPECIATION OF TRACE ELEMENTS TRANSPORTED FROM RICE FIELD TO CANAL DURING A FLOODING EVENT

Trace element pollution of soils, sediments and surface water can pose a risk for the local population and the environment of Vietnam. Rice fields can be affected by storm events, which cause the release of trace elements into surface water and transport them into drinking wells. The aim of this study was to investigate if dissolved and suspended As, Pb and Zn concentrations in surface water of a paddy rice fields and an irrigation canals increased during a flooding event and exceed the Vietnamese Surface Water Quality Standards and WHO Guidelines for Drinking-water Quality. The study site is a rice field area in the Thanh Hoa province in Central Vietnam, which experiences an average of 2.4 storms every year causing overflow of streams and low-order canals. Concentrations of As increased during the flooding event with dissolved As being the prevailing fraction, which followed a late flush behavior. Lead showed no significant difference in concentration over time. Zn concentrations only increased significantly in the canal upstream the field in the morning of the first day. Suspended Zn dominated at that time, following the first flush behavior of TSS concentrations. Concentrations of As, Pb and Zn did not exceed the Vietnamese Surface Water Quality Standards or WHO Guidelines for Drinking-water Quality at any time and they are therefore of no concern for the health of the local populatio

Adsorptive removal of Pb (II) using exfoliated graphite adsorbent:influence of experimental conditions and magnetic CoFe2O4 decoration

The worm-like exfoliated graphite (EG) based adsorbents prepared from low-cost natural graphite flakes via facile synthesis processes have been found to be efficient adsorbents when it comes to removing Pb (II) from aqueous solution. EG was fabricated by chemical intercalation and microwave assisted exfoliation. Furthermore, the magnetic exfoliated graphite (MEG) was developed by incorporating CoFe2O4 particles into the EG layers using the citric acid based sol-gel technique. Adsorption behaviour of Pb (II) on the as-prepared adsorbents was investigated by taking several experimental conditions into consideration such as contact time, initial concentration, adsorbent dosage, and pH value. The results with initial neutral pH indicated that the adsorption isotherms for Pb (II) on the EG and MEG were well consistent with the Langmuir isotherm model revealing the maximum adsorption capacity of 106 mg/g and 68 mg/g for EG and MEG, respectively. The adsorption kinetics of Pb (II) was found to adhere to the pseudo-second-order kinetic model. The chemical interaction between ? electrons on graphite sheets and Pb (II) ions was suggested to play an essential role in the adsorption mechanism. The introduction of magnetic CoFe2O4 to the EG was found to induce the shift of optimal pH value to a more basic condition. The characterization of the adsorbents was performed using relevant analysis techniques such as Scanning electron microscope (SEM), X–ray powder diffraction (XRD), vibrating-sample magnetometer (VSM), and Fourier-transform infrared (FTIR). The results of this work suggest a high possibility for application of the as-prepared modified graphite to remove hazardous substances in practical wastewater treatment systems. ABSTRAK:  Penyerap Pengelupas Grafit (EG) yang berupa seperti cacing dihasilkan dari grafit semulajadi yang murah melalui proses sintesis serpihan, ia juga merupakan penyerap yang bagus dalam mengasingkan Pb (II) daripada larutan akues. EG direka dengan tindak balas interkalasi kimia dan pengelupasan melalui gelombang mikro. Tambahan, pengelupas grafit magnet (MEG) telah dihasilkan dengan memasukkan zarah CoFe2O4 ke dalam lapisan EG menggunakan teknik sol-gel yang berasaskan asid sitrik. Tindak balas penyerapan Pb (II) pada penyerap yang disiapkan ini, dikaji dengan mengambil kira beberapa keadaan eksperimen seperti waktu disentuh, konsentrasi awal, dos penyerap dan nilai pH.  Hasil keputusan pH neutral awal menunjukkan bahawa isoterm penyerapan bagi Pb (II) pada EG dan MEG adalah konsisten dengan model isoterm Langmuir. Ini menunjukkan kapasiti penyerapan maksimum 106 mg/g dan 68 mg/g bagi EG dan MEG, masing-masing. Penyerapan kinetik Pb (II) didapati mematuhi model kinetik pesudo-order-kedua. Interaksi kimia antara elektron ? pada helaian grafit dan ion Pb (II) memainkan peranan penting dalam mekanisme penyerapan. Pengenalan magnet CoFe2O4 kepada EG didapati telah mengubah nilai pH optimum kepada keadaan asal. Pengelasan penyerapan dilakukan menggunakan teknik analisis yang relevan seperti Mikroskop Elektron Pengimbasan (SEM), Difraksi Serbuk sinar-X (XRD), Magnetometer Sampel-Getaran (VSM) dan Inframerah Perubahan-Fourier (FTIR). Hasil kerja ini mencadangkan kemungkinan besar bagi penggunaan grafit ubah suai yang disediakan bagi membuang bahan berbahaya dalam sistem rawatan air sisa praktikal

Crystallography: Deep understanding the mechanism of -form nucleation in cooling crystallization of L-glutamic acid

The mechanism of heterogeneous β-form nucleation was investigated during the phase transformation of L-glutamic acid in the stirring cooling crystallization. In the present study, a new mechanism of heterogeneous β-form nucleation was explored, where the β-form nuclei was favorably crystallized on the (001) and (011) surfaces rather than the (111) surface of α-form crystal during the phase transformation. This result was confirmed via the molecular simulation, in which the functional groups of molecule on various surfaces of α-form crystal were different, so the degree of lattice matching (E) between the α-form substrate surfaces and β-form molecule aggregate was distinguished and ordered as (001) (011) (111), meaning that the nucleation of heterogeneous β-form was more facilitated on the (001) and (011) surfaces compared to that on the (111) surface of α-form crystal. Keywords. Crystallization, crystallography, polymorphism, nucleation, crystal growth

Anatomical Characteristics and Variants of Prostatic Artery in Patients of Benign Hyperplasia Prostate by Digital Subtraction Angiography

AIM: This work is aimed to describe anatomical features and variants of the prostatic artery (PA) using digital subtraction angiography (DSA). METHODS: This is a descriptive statistic study. We reviewed the DSA of 348 patients, who had a PA embolisation to reduce the benign prostatic hyperplasia (BPH) symptoms at Radiology Department of Bach Mai Hospital from Oct – 2014 to Oct – 2018. RESULTS: PA was found at 660 pelvic halves, of which 30 pelvic halves (4.5%) had two PAs, 630 pelvic halves had one PA. In terms of the origin of PA, in total 690 PAs, the percentage of type 1, 2, 3, 4 and 5 was successively 33.9%, 13.9%, 18.3%, 23.9% and 10.4%, respectively. Atherosclerosis of PA observed in 20.9%. The ‘corkscrew’ pattern was found in 30.4%. The average diameter of PA was 1.5 ± 0.34mm. The anastomosis of PA with surrounding arteries was common. PA may supply rectum (6.1%), seminal vesical (9.6%), bladder (5.2%), contralateral prostatic parenchyma (13.0%), surrounding soft-tissues (3.5%). CONCLUSION: The common trunk with SVA superior vesical artery was the most common origin of PA. Anastomoses of PA with surrounding tissues were complex

Simultaneously induced mutations in eIF4E genes by CRISPR/Cas9 enhance PVY resistance in tobacco

Tobacco is an important commercial crop and a rich source of alkaloids for pharmaceutical and agricultural applications. However, its yield can be reduced by up to 70% due to virus infections, especially by a potyvirus Potato virus Y (PVY). The replication of PVY relies on host factors, and eukaryotic translation initiation factor 4Es (eIF4Es) have already been identified as recessive resistance genes against potyviruses in many plant species. To investigate the molecular basis of PVY resistance in the widely cultivated allotetraploid tobacco variety K326, we developed a dual guide RNA CRISPR/Cas9 system for combinatorial gene editing of two clades, eIF4E1 (eIF4E1-S and eIF4E1-T) and eIF4E2 (eIF4E2-S and eIF4E2-T) in the eIF4E gene family comprising six members in tobacco. We screened for CRISPR/Cas9-induced mutations by heteroduplex analysis and Sanger sequencing, and monitored PVY(O) accumulation in virus challenged regenerated plants by DAS-ELISA both in T0 and T1 generations. We found that all T0 lines carrying targeted mutations in the eIF4E1-S gene displayed enhanced resistance to PVY(O) confirming previous reports. More importantly, our combinatorial approach revealed that eIF4E1-S is necessary but not sufficient for complete PVY resistance. Only the quadruple mutants harboring loss-of-function mutations in eIF4E1-S, eIF4E1-T, eIF4E2-S and eIF4E2-T showed heritable high-level resistance to PVY(O) in tobacco. Our work highlights the importance of understanding host factor redundancy in virus replication and provides a roadmap to generate virus resistance by combinatorial CRISPR/Cas9-mediated editing in non-model crop plants with complex genomes

Chemical constituents of Chirita drakei Burtt collected in Ha Long bay, Quang Ninh province, Viet Nam. Part 1. Compounds isolated from the n-hexane and ethyl acetate extracts.

Two triterpenes, an anthraquinone, two lignans and a phenolic compound were isolated from the n-hexane and ethyl acetate extracts of the aerial part of Chirita drakei Burtt collected in islands, on mountain slopes of Ha Long bay, Quang Ninh province. Their structures have been elucidated by mass, NMR spectroscopy and comparison with published data. There are no report on the chemical constituents of Chirita drakei before our study. Keywords. Chirita drakei, triterpene, anthraquinone, lignin