Artocarpus altilis Leaves Activity in Inhibiting α-Amylase Enzyme as Oral Antidiabetic Drug Candidate

Background: The search for effective antidiabetic drugs remains to be a focus of research in the world. Artocarpus have been used as traditional medicine in South-East Asia. One of the species, Artocarpus altilis has been known in Indonesia as traditional treatment for diabetic. Objective: This research aimed to discover α-amylase inhibitor activity of Artocarpus altilis leaves. Methods: Leaves were extracted by maceration method, followed by phytochemical screening and quercetin identification using LC-MS method. Inhibition of α-amylase was measured using UV-Vis spectrophotometer at 524 nm wavelength, while antioxidant activity was determined using DPPH. Results: Artocarpus altilis leaves ethanol extract exhibited activity against α-amylase with 155.96 ppm IC50 (0.27 times relative potential compared to acarbose) and the extract showed antioxidant activity with the IC50 of 999.96 ppm. Conclusion: Artocarpus altilis showed activity as the α-amylase inhibitor