Patient Characteristics.

<p>CCS Class – Canadian Cardiovascular Society Angina Class.</p><p>PCI – percutaneous coronary intervention.</p><p>CAD – coronary artery disease.</p><p>MI – myocardial infarction.</p><p>ACEI/ARB – angiotensin converting enzyme/angiotensin II receptor blocker.</p><p>eGFR – estimated glomerular filtration rate ml/min/1.73 m².</p><p>SD – standard deviation.</p><p>SEM – standard error of the mean.</p

Effect of statin on cultured angiogenic cell (CAC) function <i>in vitro</i>.

<p>(<b>A</b>) Atorvastatin supplementation of the media (0.1 mM). Statin treatment improves CAC attachment to bare metal stent struts <i>in vitro</i> (n = 10). * indicates p<0.01. (<b>B</b>) Representative photos showing DAPI nuclear staining of CAC attachment to stent struts. (<b>C</b>) Atorvastatin supplementation of the media at 0.1 mM does not effect VEGF secretion by EPCs (n = 6, p>0.05). (<b>D</b>) Statin does not ameliorate survival of CACs in culture (n = 6, p>0.05).</p

Laboratory characteristics of patients.

<p>WBC – white blood cell 10⁹ cells/L.</p><p>HbA1C – hemoglobin A1C.</p><p>HDL – high density lipoprotein mmol/L.</p><p>LDL – low density lipoprotein mmol/L.</p><p>TG – triglycerides mmol/L.</p><p>SEM – standard error of the mean.</p

<i>In vitro</i> assessment of cultured angiogenic cells (CAC).

<p>(<b>A</b>) Comparison of baseline CAC levels in patients with CAD (n = 32) <i>vs</i>. healthy controls (non-CAD). (<b>B</b>) CAC levels expressed at each interval as a ratio to baseline levels (taken three days prior to the procedure) for patients receiving and not receiving Atorvastatin therapy (n = 10 per group). * indicates p<0.05, # indicates p<0.01.</p

Flow cytometric analysis of CD45dimCD34+CD133+CD117+ endothelial progenitor cells (EPC).

<p>(<b>A</b>) Sample gating strategy. (<b>B</b>) EPC levels, expressed at each interval as a ratio to baseline levels (taken three days prior to PCI) for patients receiving and not receiving Atorvastatin therapy (n = 10 per group). * indicates p<0.05.</p

Additional file 1: of Association between plasminogen activator inhibitor-1 and cardiovascular events: a systematic review and meta-analysis

Association between plasminogen activator inhibitor-1 and cardiovascular events: a systematic review and meta-analysis. (DOCX 4410 kb

Baseline and 48 hour laboratory values.

<p>Baseline and 48 hour laboratory values.</p

Proportion of patients achieving platelet reactivity unit values <208 during the first 48 hours following ticagrelor bolus alone (red bars) or clopidogrel followed by reloading with a ticagrelor bolus (gray bars).

<p>Clopidogrel and ticagrelor co-therapy resulted in more patients achieving target platelet inhibition at 1, 2, 4, and 6 hours following ticagrelor administration.</p

Baseline characteristics.

<p>BP: blood pressure; CABG: coronary artery bypass grafting; GFR: glomerular filtration rate; MDRD: modification of diet in renal disease; SD: standard deviation; CK: creatinine kinase; TIMI: thrombolysis in myocardial infarction; IQR: interquartile range.</p

Platelet reactivity units following ticagrelor administration.

<p>All values represent median and interquartile range.</p