Internal Migration, Sport and the Scottish Diaspora in England.

Sport has been argued to play an important role for members of diasporic groups of various origins and in various locations (Burdsey, 2006; Carrington, 2010; Darby and Hassan, 2008; Kaufman, 2005). However, little attention has been paid to the role sport plays for ‘internal migrants’ who migrate to contrasting locations within a nation-state, despite the potential for significant contrasts in the prevailing sporting cultures found in different regions of the same nation-state. This article therefore aims to make a contribution towards understanding this relationship by reflecting upon the role sport plays for members of the Scottish diaspora living in England, drawing upon interviews and personal reflections from a number of Scottish ‘internal migrants’ located within the United Kingdom. In particular, discussion attempts to draw attention to the central role sport plays for these individuals in order to maintain a cultural attachment with their Scottish birthplace, given the relative lack of other cultural practices or associations which could be used to achieve this goal. Comparisons are also drawn with studies of the Scottish diaspora in more distant geographic contexts, as well as similar diasporic groups in the English context such as the Irish diaspora. These comparisons allow for a consideration of the impact of geographic proximity and cultural proximity on the relative importance of sport and other cultural practices for Scots living in England, identifying a number of important issues for those studying the role played by sport in the maintenance of a cultural attachment with ‘home’ for various diasporic groups

Anti-CD8 monoclonal antibody-mediated depletion alters the phenotype and behavior of surviving CD8+ T cells.

It is common practice for researchers to use antibodies to remove a specific cell type to infer its function. However, it is difficult to completely eliminate a cell type and there is often limited or no information as to how the cells which survive depletion are affected. This is particularly important for CD8+ T cells for two reasons. First, they are more resistant to mAb-mediated depletion than other lymphocytes. Second, targeting either the CD8α or CD8β chain could induce differential effects. We show here that two commonly used mAbs, against either the CD8α or CD8β subunit, can differentially affect cellular metabolism. Further, in vivo treatment leaves behind a population of CD8+ T cells with different phenotypic and functional attributes relative to each other or control CD8+ T cells. The impact of anti-CD8 antibodies on CD8+ T cell phenotype and function indicates the need to carefully consider the use of these, and possibly other "depleting" antibodies, as they could significantly complicate the interpretation of results or change the outcome of an experiment. These observations could impact how immunotherapy and modulation of CD8+ T cell activation is pursued