24 research outputs found
Sustainable transport development in the XXI century begining: hygienic, toxicological and ecological aspect
From the standpoint of sustainable transport development it is necessary to define the place of the problem and ways of further development of transport medicine. These tasks are closely connected with the development of basic and applied sciences, reforming the health maintenance of transport workers, their reliable and safe operation. An important aspect of transport medicine is ecological because transport makes a significant impact on the environment, accounting for example about 25 % of global energy consumption and carbon dioxide emissions. Not by chance, sustainable transport will be paid a great attention to the Paris France Sustainable Innovation Forum 2015 to be held from 30 November to 11 December 2015. It will be made a new international agreement to reduce emissions into the atmosphere (COP 21) in addition to the Kyoto Protocol (CRPeleven). Medicine Transport and in solving these problems has an important role.ΠΠΎΠ½ΡΠ΅ΠΏΡΡΡ ΡΡΠ°Π»ΠΎΠ³ΠΎ ΡΠΎΠ·Π²ΠΈΡΠΊΡ Π΄ΠΎΠΌΡΠ½ΡΡ Π² Π±ΡΠ»ΡΡΠΎΡΡΡ Π΄ΠΎΠΊΡΠΌΠ΅Π½ΡΡΠ² ΠΠΠ, ΠΠΠΠ, ΠΠΠ, ΠΠ‘ ΡΠ° ΡΠ½ΡΠΈΡ
ΠΌΡΠΆΠ½Π°ΡΠΎΠ΄Π½ΠΈΡ
ΠΎΡΠ³Π°Π½ΡΠ·Π°ΡΡΠΉ, ΡΠΊΡ Π²ΠΈΠ·Π½Π°ΡΠ°ΡΡΡ ΡΠ»ΡΡ
ΠΈ Ρ ΠΏΠ΅Ρ-ΡΠΏΠ΅ΠΊΡΠΈΠ²ΠΈ ΡΠ΅ΡΠΎΡΠΌΡΠ²Π°Π½Π½Ρ ΡΠΎΡΡΠ°Π»ΡΠ½ΠΎ-Π΅ΠΊΠΎΠ½ΠΎΠΌΡΡΠ½ΠΎΡ Π±Π°Π·ΠΈ, ΡΡ ΡΠ΅Ρ
Π½ΠΎΠ»ΠΎΠ³ΡΡΠ½ΠΎΡ, ΠΎΡΠ³Π°Π½ΡΠ·Π°ΡΡΠΉΠ½ΠΎΡ, Π΅ΠΊΠΎΠ»ΠΎΠ³ΠΎΠ³ΡΠ³ΡΡΠ½ΡΡΠ½ΠΎΡ ΡΠΊΠ»Π°Π΄ΠΎΠ²ΠΈΡ
Π½Π° ΠΏΠ΅ΡΡΠΎΠ΄ Π΄ΠΎ 2030-Π³ΠΎ Ρ ΠΏΠΎΠ΄Π°Π»ΡΡΡ ΡΠΎΠΊΠΈ. ΠΡ
Ρ
Π°ΡΠ°ΠΊΡΠ΅ΡΠ½ΠΎΡ ΠΎΡΠΎΠ±Π»ΠΈΠ²ΡΡΡΡ Ρ Π²ΠΈΠΏΠ΅ΡΠ΅Π΄ΠΆΠ°Π»ΡΠ½ΠΈΠΉ ΡΠΎΠ·Π²ΠΈΡΠΎΠΊ ΡΡΠ°Π½ΡΠΏΠΎΡΡΠ½ΠΎΡ Π³Π°Π»ΡΠ·Ρ, ΡΠ΅ΡΠ΅Π΄ Π°ΡΠΏΠ΅ΠΊΡΡΠ² Π·Π°Π±Π΅Π·ΠΏΠ΅ΡΠ΅Π½Π½Ρ Π±Π΅Π·ΠΏΠ΅ΠΊΠΈ ΡΠΊΠΎΡ Π°Π²ΡΠΎΡΠ°ΠΌΠΈ Π΄Π°Π½ΠΎΡ ΡΠΎΠ±ΠΎΡΠΈ Π²ΠΈΠ΄ΡΠ»Π΅Π½Ρ: Π²ΠΎΠ΄ΠΎΠ·Π°Π±Π΅Π·ΠΏΠ΅ΡΠ΅Π½Π½Ρ Ρ Π·Π°Ρ
ΠΈΡΡ Π‘Π²ΡΡΠΎΠ²ΠΎΠ³ΠΎ ΠΎΠΊΠ΅Π°Π½Ρ Π²ΡΠ΄ Π°Π½ΡΡΠΎΠΏΠΎΠ³Π΅Π½Π½ΠΈΡ
Π·Π°Π±ΡΡΠ΄Π½Π΅Π½Ρ, ΠΏΠΎΠ»ΡΠΌΠ΅ΡΠ½Ρ ΠΌΠ°ΡΠ΅ΡΡΠ°Π»ΠΈ Π½Π° ΡΡΠ°Π½ΡΠΏΠΎΡΡΡ ΡΠ° ΠΏΠ΅ΡΠ΅Π²Π΅Π·Π΅Π½Π½Ρ Π½Π΅Π±Π΅Π·ΠΏΠ΅ΡΠ½ΠΈΡ
Π²Π°Π½ΡΠ°ΠΆΡΠ². ΠΠ° ΠΎΡΠ½ΠΎΠ²Ρ ΡΠΈΡΡΠ΅ΠΌΠ½ΠΎΠ³ΠΎ ΠΏΡΠ΄Ρ
ΠΎΠ΄Ρ ΠΏΠΎΠ±ΡΠ΄ΠΎΠ²Π°Π½Ρ ΡΠ½ΡΠ΅Π³ΡΠ°Π»ΡΠ½Ρ ΡΡ
Π΅ΠΌΠΈ ΡΠΎΠ·Π²ΠΈΡΠΊΡ ΠΊΠΎΠΆΠ½ΠΎΠ³ΠΎ Π½Π°ΠΏΡΡΠΌΡ. Π£ Π²ΠΈΡΠ½ΠΎΠ²ΠΊΡ ΠΏΠΎΠΊΠ°Π·Π°Π½ΠΎ ΠΌΡΡΡΠ΅, ΠΎΡΠ½ΠΎΠ²Π½Ρ ΡΠΊΠ»Π°Π΄ΠΎΠ²Ρ ΡΠ° Π²Π·Π°ΡΠΌΠΎΠ·Π²βΡΠ·ΠΊΠΈ ΠΌΠ΅Π΄ΠΈΡΠΈΠ½ΠΈ ΡΡΠ°Π½ΡΠΏΠΎΡΡΡ Π· ΡΠ½ΡΠΈΠΌΠΈ ΡΡΠ½Π΄Π°ΠΌΠ΅Π½ΡΠ°Π»ΡΠ½ΠΈΠΌΠΈ Ρ ΠΏΡΠΈΠΊΠ»Π°Π΄Π½ΠΈΠΌΠΈ Π½Π°ΡΠΊΠΎΠ²ΠΈΠΌΠΈ Π΄ΠΈΡΡΠΈΠΏΠ»ΡΠ½Π°ΠΌΠΈ, ΡΠΎ Π΄ΠΎΠ·Π²ΠΎΠ»ΡΡ ΡΡ ΡΠ°Ρ
ΡΠ²ΡΡΠΌ Π±ΡΠ°ΡΠΈ Π°ΠΊΡΠΈΠ²Π½Ρ ΡΡΠ°ΡΡΡ Ρ Π²ΠΈΡΡΡΠ΅Π½Π½Ρ Π³Π»ΠΎΠ±Π°Π»ΡΠ½ΠΎΠ³ΠΎ ΠΌΡΠΆΠ³Π°Π»ΡΠ·Π΅Π²ΠΎΠ³ΠΎ Π·Π°Π²Π΄Π°Π½Π½Ρ β ΡΡΠ°Π»ΠΎΠΌΡ ΡΠΎΠ·Π²ΠΈΡΠΊΡ ΡΡΠ°Π½ΡΠΏΠΎΡΡΡ Π² XXI ΡΡΠΎΡΡΡΡΡ.ΠΠΎΠ½ΡΠ΅ΠΏΡΠΈΡ ΡΡΡΠΎΠΉΡΠΈΠ²ΠΎΠ³ΠΎ ΡΠ°Π·Π²ΠΈΡΠΈΡ Π΄ΠΎΠΌΠΈΠ½ΠΈΡΡΠ΅Ρ Π² Π±ΠΎΠ»ΡΡΠΈΠ½ΡΡΠ²Π΅ Π΄ΠΎΠΊΡΠΌΠ΅Π½ΡΠΎΠ² ΠΠΠ, ΠΠΠ, ΠΠΠ’, ΠΠ‘ ΠΈ Π΄ΡΡΠ³ΠΈΡ
ΠΌΠ΅ΠΆΠ΄ΡΠ½Π°ΡΠΎΠ΄Π½ΡΡ
ΠΎΡΠ³Π°Π½ΠΈΠ·Π°ΡΠΈΠΉ, ΠΎΠΏΡΠ΅Π΄Π΅Π»ΡΡΡΠΈΡ
ΠΏΡΡΠΈ ΠΈ ΠΏΠ΅ΡΡΠΏΠ΅ΠΊΡΠΈΠ²Ρ ΡΠ΅ΡΠΎΡΠΌΠΈΡΠΎΠ²Π°Π½ΠΈΡ ΡΠΎΡΠΈΠ°Π»ΡΠ½ΠΎΡΠΊΠΎΠ½ΠΎΠΌΠΈΡΠ΅ΡΠΊΠΎΠΉ Π±Π°Π·Ρ, Π΅Π΅ ΡΠ΅Ρ
Π½ΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΎΠΉ, ΠΎΡΠ³Π°Π½ΠΈΠ·Π°ΡΠΈΠΎΠ½Π½ΠΎΠΉ, ΡΠΊΠΎΠ»ΠΎΠ³ΠΎ-Π³ΠΈΠ³ΠΈΠ΅Π½ΠΈΡΠ΅ΡΠΊΠΎΠΉ ΡΠΎΡΡΠ°Π²Π»ΡΡΡΠΈΡ
Π½Π° ΠΏΠ΅ΡΠΈΠΎΠ΄ Π΄ΠΎ 2030 ΠΈ ΠΏΠΎΡΠ»Π΅Π΄ΡΡΡΠΈΠ΅ Π³ΠΎΠ΄Ρ. ΠΡ
Ρ
Π°ΡΠ°ΠΊΡΠ΅ΡΠ½ΠΎΠΉ ΠΎΡΠΎΠ±Π΅Π½Π½ΠΎΡΡΡΡ ΡΠ²Π»ΡΠ΅ΡΡΡ ΠΎΠΏΠ΅ΡΠ΅ΠΆΠ°ΡΡΠ΅Π΅ ΡΠ°Π·Π²ΠΈΡΠΈΠ΅ ΡΡΠ°Π½ΡΠΏΠΎΡΡΠ½ΠΎΠΉ ΠΎΡΡΠ°ΡΠ»ΠΈ, ΡΡΠ΅Π΄ΠΈ Π°ΡΠΏΠ΅ΠΊΡΠΎΠ² ΠΎΠ±Π΅ΡΠΏΠ΅ΡΠ΅Π½ΠΈΡ Π±Π΅Π·ΠΎΠΏΠ°ΡΠ½ΠΎΡΡΠΈ ΠΊΠΎΡΠΎΡΠΎΠΉ Π°Π²ΡΠΎΡΠ°ΠΌΠΈ Π΄Π°Π½Π½ΠΎΠΉ ΡΠ°Π±ΠΎΡΡ Π²ΡΠ΄Π΅Π»Π΅Π½Ρ: Π²ΠΎΠ΄ΠΎΠΎΠ±Π΅ΡΠΏΠ΅ΡΠ΅Π½ΠΈΠ΅ ΠΈ Π·Π°ΡΠΈΡΠ° ΠΠΈΡΠΎΠ²ΠΎΠ³ΠΎ ΠΎΠΊΠ΅Π°Π½Π° ΠΎΡ Π°Π½ΡΡΠΎΠΏΠΎΠ³Π΅Π½Π½ΡΡ
Π·Π°Π³ΡΡΠ·Π½Π΅Π½ΠΈΠΉ, ΠΏΠΎΠ»ΠΈΠΌΠ΅ΡΠ½ΡΠ΅ ΠΌΠ°ΡΠ΅ΡΠΈΠ°Π»Ρ Π½Π° ΡΡΠ°Π½ΡΠΏΠΎΡΡΠ΅ ΠΈ ΠΏΠ΅ΡΠ΅Π²ΠΎΠ·ΠΊΠ° ΠΎΠΏΠ°ΡΠ½ΡΡ
Π³ΡΡΠ·ΠΎΠ². ΠΠ° ΠΎΡΠ½ΠΎΠ²Π΅ ΡΠΈΡΡΠ΅ΠΌΠ½ΠΎΠ³ΠΎ ΠΏΠΎΠ΄Ρ
ΠΎΠ΄Π° ΠΏΠΎΡΡΡΠΎΠ΅Π½Ρ ΠΈΠ½ΡΠ΅Π³ΡΠ°Π»ΡΠ½ΡΠ΅ ΡΡ
Π΅ΠΌΡ ΡΠ°Π·Π²ΠΈΡΠΈΡ ΠΊΠ°ΠΆΠ΄ΠΎΠ³ΠΎ Π½Π°ΠΏΡΠ°Π²Π»Π΅Π½ΠΈΡ. Π Π·Π°ΠΊΠ»ΡΡΠ΅Π½ΠΈΠΈ ΠΏΠΎΠΊΠ°Π·Π°Π½ΠΎ ΠΌΠ΅ΡΡΠΎ, ΠΎΡΠ½ΠΎΠ²Π½ΡΠ΅ ΡΠΎΡΡΠ°Π²Π»ΡΡΡΠΈΠ΅ ΠΈ Π²Π·Π°ΠΈΠΌΠΎΡΠ²ΡΠ·ΠΈ ΠΌΠ΅Π΄ΠΈΡΠΈΠ½Ρ ΡΡΠ°Π½ΡΠΏΠΎΡΡΠ° Ρ Π΄ΡΡΠ³ΠΈΠΌΠΈ ΡΡΠ½Π΄Π°ΠΌΠ΅Π½ΡΠ°Π»ΡΠ½ΡΠΌΠΈ ΠΈ ΠΏΡΠΈΠΊΠ»Π°Π΄Π½ΡΠΌΠΈ Π½Π°ΡΡΠ½ΡΠΌΠΈ Π΄ΠΈΡΡΠΈΠΏΠ»ΠΈΠ½Π°ΠΌΠΈ, ΡΡΠΎ ΠΏΠΎΠ·Π²ΠΎΠ»ΡΠ΅Ρ Π°ΠΊΡΠΈΠ²Π½ΠΎ ΡΡΠ°ΡΡΠ²ΠΎΠ²Π°ΡΡ Π² ΡΠ΅ΡΠ΅Π½ΠΈΠΈ Π³Π»ΠΎΠ±Π°Π»ΡΠ½ΠΎΠΉ ΠΌΠ΅ΠΆΠΎΡΡΠ°ΡΠ»Π΅Π²ΠΎΠΉ Π·Π°Π΄Π°ΡΠΈ β ΡΡΡΠΎΠΉΡΠΈΠ²ΠΎΠΌ ΡΠ°Π·Π²ΠΈΡΠΈΠΈ ΡΡΠ°Π½ΡΠΏΠΎΡΡΠ° Π² XXI ΡΡΠΎΠ»Π΅ΡΠΈΠΈ
ΠΠ½Π΅ΠΊΠ»Π΅ΡΠΎΡΠ½ΡΠ΅ Π»ΠΎΠ²ΡΡΠΊΠΈ Π½Π΅ΠΉΡΡΠΎΡΠΈΠ»ΠΎΠ² (NETs) Π² ΠΏΠ°ΡΠΎΠ³Π΅Π½Π΅Π·Π΅ ΡΡΠΎΠΌΠ±ΠΎΠ·Π° ΠΈ ΡΡΠΎΠΌΠ±ΠΎΠ²ΠΎΡΠΏΠ°Π»ΠΈΡΠ΅Π»ΡΠ½ΡΡ Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΠΉ
This article summarizes numerous studies on the relationship of biological processes such as inflammation and thrombosis. The huge role of neutrophils and the extracellular neutrophil traps (NETs) secreted by them has been demonstrated. The discovery of NETs has opened new horizons in the understanding of neutrophil biology and the role of these cells in the body. The use of chromatin in combination with the intracellular proteins, as an effective antimicrobial agent has ancient roots and changes our understanding of chromatin only as a carrier of genetic information. Through NETs, neutrophils can contribute to the development of pathological venous and arterial thrombosis or immunothrombosis, as well as atherosclerosis. NETs release has been shown to be one of the causes of thrombosis in conditions such as sepsis and cancer. The presence of NETs in these diseases and conditions makes it possible to use them or individual components as potential biomarkers. NETs and their components may be attractive as therapeutic targets. Further studies of neutrophils and NETs are needed to develop new approaches to the diagnosis and treatment of inflammatory and thrombotic conditions. Perhaps long-forgotten drugs will find a new area for effective use.Π Π΄Π°Π½Π½ΠΎΠΉ ΡΡΠ°ΡΡΠ΅ ΠΎΠ±ΠΎΠ±ΡΠ΅Π½Ρ ΠΌΠ½ΠΎΠ³ΠΎΡΠΈΡΠ»Π΅Π½Π½ΡΠ΅ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ ΠΎ Π²Π·Π°ΠΈΠΌΠΎΡΠ²ΡΠ·ΠΈ ΡΠ°ΠΊΠΈΡ
Π±ΠΈΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΏΡΠΎΡΠ΅ΡΡΠΎΠ² ΠΊΠ°ΠΊ Π²ΠΎΡΠΏΠ°Π»Π΅Π½ΠΈΠ΅ ΠΈ ΡΡΠΎΠΌΠ±ΠΎΠΎΠ±ΡΠ°Π·ΠΎΠ²Π°Π½ΠΈΠ΅. ΠΡΠΎΠ΄Π΅ΠΌΠΎΠ½ΡΡΡΠΈΡΠΎΠ²Π°Π½Π° ΠΎΠ³ΡΠΎΠΌΠ½Π°Ρ ΡΠΎΠ»Ρ Π½Π΅ΠΉΡΡΠΎΡΠΈΠ»Π»ΠΎΠ² ΠΈ Π²ΡΠ΄Π΅Π»ΡΠ΅ΠΌΡΡ
ΠΈΠΌΠΈ Π²Π½Π΅ΠΊΠ»Π΅ΡΠΎΡΠ½ΡΡ
Π»ΠΎΠ²ΡΡΠ΅ΠΊ Π½Π΅ΠΉΡΡΠΎΡΠΈΠ»ΠΎΠ² (Neutrophil Extracellular Traps, NETs). ΠΡΠΊΡΡΡΠΈΠ΅ NETs ΡΠ°ΡΡΠΈΡΠΈΠ»ΠΎ Π³ΠΎΡΠΈΠ·ΠΎΠ½ΡΡ Π² ΠΏΠΎΠ½ΠΈΠΌΠ°Π½ΠΈΠΈ Π±ΠΈΠΎΠ»ΠΎΠ³ΠΈΠΈ Π½Π΅ΠΉΡΡΠΎΡΠΈΠ»ΠΎΠ² ΠΈ ΡΠΎΠ»ΠΈ ΡΡΠΈΡ
ΠΊΠ»Π΅ΡΠΎΠΊ Π² ΠΎΡΠ³Π°Π½ΠΈΠ·ΠΌΠ΅. ΠΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½ΠΈΠ΅ Ρ
ΡΠΎΠΌΠ°ΡΠΈΠ½Π° Π² ΡΠΎΡΠ΅ΡΠ°Π½ΠΈΠΈ Ρ Π²Π½ΡΡΡΠΈΠΊΠ»Π΅ΡΠΎΡΠ½ΡΠΌΠΈ Π±Π΅Π»ΠΊΠ°ΠΌΠΈ Π² ΠΊΠ°ΡΠ΅ΡΡΠ²Π΅ ΠΏΡΠΎΡΠΈΠ²ΠΎΠΌΠΈΠΊΡΠΎΠ±Π½ΠΎΠ³ΠΎ ΡΡΠ΅Π΄ΡΡΠ²Π° ΠΈΠΌΠ΅Π΅Ρ Π΄ΡΠ΅Π²Π½ΡΡ ΠΈΡΡΠΎΡΠΈΡ ΠΈ ΠΌΠ΅Π½ΡΠ΅Ρ Π½Π°ΡΠ΅ ΠΏΡΠ΅Π΄ΡΡΠ°Π²Π»Π΅Π½ΠΈΠ΅ ΠΎ Ρ
ΡΠΎΠΌΠ°ΡΠΈΠ½Π΅ ΡΠΎΠ»ΡΠΊΠΎ ΠΊΠ°ΠΊ ΠΎ Π½ΠΎΡΠΈΡΠ΅Π»Π΅ Π³Π΅Π½Π΅ΡΠΈΡΠ΅ΡΠΊΠΎΠΉ ΠΈΠ½ΡΠΎΡΠΌΠ°ΡΠΈΠΈ. ΠΠ»Π°Π³ΠΎΠ΄Π°ΡΡ NETs, Π½Π΅ΠΉΡΡΠΎΡΠΈΠ»Ρ ΠΌΠΎΠ³ΡΡ ΡΠΏΠΎΡΠΎΠ±ΡΡΠ²ΠΎΠ²Π°ΡΡ ΡΠ°Π·Π²ΠΈΡΠΈΡ ΠΏΠ°ΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ Π²Π΅Π½ΠΎΠ·Π½ΠΎΠ³ΠΎ ΠΈ Π°ΡΡΠ΅ΡΠΈΠ°Π»ΡΠ½ΠΎΠ³ΠΎ ΡΡΠΎΠΌΠ±ΠΎΠ·Π° ΠΈΠ»ΠΈ ΠΈΠΌΠΌΡΠ½ΠΎΡΡΠΎΠΌΠ±ΠΎΠ·Π°, Π° ΡΠ°ΠΊΠΆΠ΅ Π°ΡΠ΅ΡΠΎΡΠΊΠ»Π΅ΡΠΎΠ·Π°. ΠΡΡΠ²ΠΎΠ±ΠΎΠΆΠ΄Π΅Π½ΠΈΠ΅ NETs ΡΠ²Π»ΡΠ΅ΡΡΡ, ΠΊΠ°ΠΊ Π±ΡΠ»ΠΎ ΠΏΠΎΠΊΠ°Π·Π°Π½ΠΎ, ΠΎΠ΄Π½ΠΎΠΉ ΠΈΠ· ΠΏΡΠΈΡΠΈΠ½ ΡΡΠΎΠΌΠ±ΠΎΠΎΠ±ΡΠ°Π·ΠΎΠ²Π°Π½ΠΈΡ ΠΏΡΠΈ ΡΠ°ΠΊΠΈΡ
ΡΠΎΡΡΠΎΡΠ½ΠΈΡΡ
ΠΊΠ°ΠΊ ΡΠ΅ΠΏΡΠΈΡ ΠΈ ΡΠ°ΠΊ. ΠΠ°Π»ΠΈΡΠΈΠ΅ NETs ΠΏΡΠΈ ΡΡΠΈΡ
Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΡΡ
ΠΈ ΡΠΎΡΡΠΎΡΠ½ΠΈΡΡ
Π΄Π°Π΅Ρ Π²ΠΎΠ·ΠΌΠΎΠΆΠ½ΠΎΡΡΡ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°ΡΡ ΠΈΡ
ΠΈΠ»ΠΈ ΠΎΡΠ΄Π΅Π»ΡΠ½ΡΠ΅ ΠΊΠΎΠΌΠΏΠΎΠ½Π΅Π½ΡΡ Π² ΠΊΠ°ΡΠ΅ΡΡΠ²Π΅ ΠΏΠΎΡΠ΅Π½ΡΠΈΠ°Π»ΡΠ½ΡΡ
Π±ΠΈΠΎΠΌΠ°ΡΠΊΠ΅ΡΠΎΠ². NETs ΠΈ ΠΈΡ
ΠΊΠΎΠΌΠΏΠΎΠ½Π΅Π½ΡΡ ΠΌΠΎΠ³ΡΡ Π±ΡΡΡ ΠΏΡΠΈΠ²Π»Π΅ΠΊΠ°ΡΠ΅Π»ΡΠ½Ρ Π² ΠΊΠ°ΡΠ΅ΡΡΠ²Π΅ ΡΠ΅ΡΠ°ΠΏΠ΅Π²ΡΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΌΠΈΡΠ΅Π½Π΅ΠΉ. ΠΠ°Π»ΡΠ½Π΅ΠΉΡΠΈΠ΅ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ Π½Π΅ΠΉΡΡΠΎΡΠΈΠ»ΠΎΠ² ΠΈ NETs Π½Π΅ΠΎΠ±Ρ
ΠΎΠ΄ΠΈΠΌΡ Π΄Π»Ρ ΡΠ°Π·ΡΠ°Π±ΠΎΡΠΊΠΈ Π½ΠΎΠ²ΡΡ
ΠΏΠΎΠ΄Ρ
ΠΎΠ΄ΠΎΠ² ΠΊ Π΄ΠΈΠ°Π³Π½ΠΎΡΡΠΈΠΊΠ΅ ΠΈ Π»Π΅ΡΠ΅Π½ΠΈΡ Π²ΠΎΡΠΏΠ°Π»ΠΈΡΠ΅Π»ΡΠ½ΡΡ
ΠΈ ΡΡΠΎΠΌΠ±ΠΎΡΠΈΡΠ΅ΡΠΊΠΈΡ
ΡΠΎΡΡΠΎΡΠ½ΠΈΠΉ. ΠΠΎΠ·ΠΌΠΎΠΆΠ½ΠΎ, Π΄Π°Π²Π½ΠΎ Π·Π°Π±ΡΡΡΠ΅ ΠΏΡΠ΅ΠΏΠ°ΡΠ°ΡΡ Π½Π°ΠΉΠ΄ΡΡ Π½ΠΎΠ²ΡΡ ΡΡΠ΅ΡΡ Π΄Π»Ρ ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎΠ³ΠΎ ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΡ
COVID-19, ΡΠ΅ΠΏΡΠΈΡΠ΅ΡΠΊΠΈΠΉ ΡΠΎΠΊ ΠΈ ΡΠΈΠ½Π΄ΡΠΎΠΌ Π΄ΠΈΡΡΠ΅ΠΌΠΈΠ½ΠΈΡΠΎΠ²Π°Π½Π½ΠΎΠ³ΠΎ Π²Π½ΡΡΡΠΈΡΠΎΡΡΠ΄ΠΈΡΡΠΎΠ³ΠΎ ΡΠ²Π΅ΡΡΡΠ²Π°Π½ΠΈΡ ΠΊΡΠΎΠ²ΠΈ. Π§Π°ΡΡΡ 2
The article discusses the issues of hemostatic system disorders in patients with COVID-19. Strengthening the coagulopathy characteristic of DIC-syndrome, is a key sign of deterioration and an unfavorable prognosis in COVID-19 patients. Data obtained by Chinese colleagues demonstrates that a significantly increased level of D-dimer is one of the predictors of death. The article also highlights the preliminary recommendations of the International society of Thrombosis and Hemostasis (ISTH, 2020) to identify markers such as D-dimer, prothrombin time and platelet count as significant predictive markers in severe COVID-19 patients. The necessity of anticoagulant therapy in hospitalized patients is justified. The article discusses the features of sepsis in pregnant women. Data from a meta-analysis of 19 studies evaluating pregnancy complications and outcomes in patients with various coronavirus infections are presented. Despite the complicated course of pregnancy, there were no cases of vertical transmission of viral infection. In the pathogenesis of severe COVID-19 complications with the formation of severe acute respiratory distress syndrome, multi-organ dysfunction, super inflammation and cytokine storm play a leading role. In connection with viral sepsis, the article discusses the role of hemophagocytic lymphohistiocytosis as a hyperinflammatory syndrome characterized by fulminant and fatal hypercytokinemia with multiple organ failure, the role of hyperferritinemia in predicting the outcomes of severe sepsis. Groups of patients at high risk of death are discussed, as well as the need for anticoagulant and anti-cytokine therapy in patients with COVID-19.Π ΡΡΠ°ΡΡΠ΅ ΡΠ°ΡΡΠΌΠ°ΡΡΠΈΠ²Π°ΡΡΡΡ Π²ΠΎΠΏΡΠΎΡΡ Π½Π°ΡΡΡΠ΅Π½ΠΈΡ ΡΠΈΡΡΠ΅ΠΌΡ Π³Π΅ΠΌΠΎΡΡΠ°Π·Π° Ρ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² Ρ COVID-19. ΠΠ°ΡΠ°ΡΡΠ°Π½ΠΈΠ΅ ΠΊΠΎΠ°Π³ΡΠ»ΠΎΠΏΠ°ΡΠΈΠΈ, Ρ
Π°ΡΠ°ΠΊΡΠ΅ΡΠ½ΠΎΠΉ Π΄Π»Ρ Π΄ΠΈΡΡΠ΅ΠΌΠΈΠ½ΠΈΡΠΎΠ²Π°Π½Π½ΠΎΠ³ΠΎ Π²Π½ΡΡΡΠΈΡΠΎΡΡΠ΄ΠΈΡΡΠΎΠ³ΠΎ ΡΠ²Π΅ΡΡΡΠ²Π°Π½ΠΈΡ ΠΊΡΠΎΠ²ΠΈ (ΠΠΠ‘-ΡΠΈΠ½Π΄ΡΠΎΠΌΠ°), β ΠΊΠ»ΡΡΠ΅Π²ΠΎΠΉ ΠΏΡΠΈΠ·Π½Π°ΠΊ ΡΡ
ΡΠ΄ΡΠ΅Π½ΠΈΡ ΡΠΎΡΡΠΎΡΠ½ΠΈΡ ΠΈ Π½Π΅Π±Π»Π°Π³ΠΎΠΏΡΠΈΡΡΠ½ΠΎΠ³ΠΎ ΠΏΡΠΎΠ³Π½ΠΎΠ·Π° Ρ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² Ρ COVID-19. ΠΡΠΈΠ²ΠΎΠ΄ΡΡΡΡ Π΄Π°Π½Π½ΡΠ΅, ΠΏΠΎΠ»ΡΡΠ΅Π½Π½ΡΠ΅ ΠΊΠΈΡΠ°ΠΉΡΠΊΠΈΠΌΠΈ ΠΊΠΎΠ»Π»Π΅Π³Π°ΠΌΠΈ, ΡΠΎΠ³Π»Π°ΡΠ½ΠΎ ΠΊΠΎΡΠΎΡΡΠΌ Π·Π½Π°ΡΠΈΡΠ΅Π»ΡΠ½ΠΎ ΠΏΠΎΠ²ΡΡΠ΅Π½Π½ΡΠΉ ΡΡΠΎΠ²Π΅Π½Ρ D-Π΄ΠΈΠΌΠ΅ΡΠ° ΡΠ²Π»ΡΠ΅ΡΡΡ ΠΎΠ΄Π½ΠΈΠΌ ΠΈΠ· ΠΏΡΠ΅Π΄ΠΈΠΊΡΠΎΡΠΎΠ² ΡΠΌΠ΅ΡΡΠΈ. Π’Π°ΠΊΠΆΠ΅ ΠΎΡΠ²Π΅ΡΠ΅Π½Ρ ΠΏΡΠ΅Π΄Π²Π°ΡΠΈΡΠ΅Π»ΡΠ½ΡΠ΅ ΡΠ΅ΠΊΠΎΠΌΠ΅Π½Π΄Π°ΡΠΈΠΈ ΠΠ΅ΠΆΠ΄ΡΠ½Π°ΡΠΎΠ΄Π½ΠΎΠ³ΠΎ ΠΎΠ±ΡΠ΅ΡΡΠ²Π° ΡΡΠΎΠΌΠ±ΠΎΠ·Π° ΠΈ Π³Π΅ΠΌΠΎΡΡΠ°Π·Π° (International Society on Thrombosis and Haemostasis, ISTH, 2020) ΠΏΠΎ ΠΎΠΏΡΠ΅Π΄Π΅Π»Π΅Π½ΠΈΡ ΡΠ°ΠΊΠΈΡ
ΠΌΠ°ΡΠΊΠ΅ΡΠΎΠ², ΠΊΠ°ΠΊ D-Π΄ΠΈΠΌΠ΅Ρ, ΠΏΡΠΎΡΡΠΎΠΌΠ±ΠΈΠ½ΠΎΠ²ΠΎΠ΅ Π²ΡΠ΅ΠΌΡ ΠΈ ΠΊΠΎΠ»ΠΈΡΠ΅ΡΡΠ²ΠΎ ΡΡΠΎΠΌΠ±ΠΎΡΠΈΡΠΎΠ², Π² ΠΊΠ°ΡΠ΅ΡΡΠ²Π΅ Π·Π½Π°ΡΠΈΠΌΡΡ
ΠΏΡΠΎΠ³Π½ΠΎΡΡΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΌΠ°ΡΠΊΠ΅ΡΠΎΠ² Ρ ΡΡΠΆΠ΅Π»ΡΡ
Π±ΠΎΠ»ΡΠ½ΡΡ
COVID-19. ΠΠ±ΠΎΡΠ½ΠΎΠ²ΡΠ²Π°Π΅ΡΡΡ Π½Π΅ΠΎΠ±Ρ
ΠΎΠ΄ΠΈΠΌΠΎΡΡΡ Π°Π½ΡΠΈΠΊΠΎΠ°Π³ΡΠ»ΡΠ½ΡΠ½ΠΎΠΉ ΡΠ΅ΡΠ°ΠΏΠΈΠΈ Ρ Π³ΠΎΡΠΏΠΈΡΠ°Π»ΠΈΠ·ΠΈΡΠΎΠ²Π°Π½Π½ΡΡ
Π±ΠΎΠ»ΡΠ½ΡΡ
. Π ΡΡΠ°ΡΡΠ΅ ΠΎΠ±ΡΡΠΆΠ΄Π°ΡΡΡΡ ΠΎΡΠΎΠ±Π΅Π½Π½ΠΎΡΡΠΈ ΡΠ΅ΠΏΡΠΈΡΠ° Ρ Π±Π΅ΡΠ΅ΠΌΠ΅Π½Π½ΡΡ
. ΠΡΠΈΠ²ΠΎΠ΄ΡΡΡΡ Π΄Π°Π½Π½ΡΠ΅ ΠΌΠ΅ΡΠ°Π°Π½Π°Π»ΠΈΠ·Π° 19 ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠΉ, ΠΏΠΎΡΠ²ΡΡΠ΅Π½Π½ΡΡ
ΠΎΡΠ΅Π½ΠΊΠ΅ ΠΎΡΠ»ΠΎΠΆΠ½Π΅Π½ΠΈΠΉ ΠΈ ΠΈΡΡ
ΠΎΠ΄ΠΎΠ² Π±Π΅ΡΠ΅ΠΌΠ΅Π½Π½ΠΎΡΡΠΈ Ρ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠΊ Ρ ΡΠ°Π·Π»ΠΈΡΠ½ΡΠΌΠΈ ΠΊΠΎΡΠΎΠ½Π°Π²ΠΈΡΡΡΠ½ΡΠΌΠΈ ΠΈΠ½ΡΠ΅ΠΊΡΠΈΡΠΌΠΈ. ΠΠ΅ΡΠΌΠΎΡΡΡ Π½Π° ΠΎΡΠ»ΠΎΠΆΠ½Π΅Π½Π½ΠΎΠ΅ ΡΠ΅ΡΠ΅Π½ΠΈΠ΅ Π±Π΅ΡΠ΅ΠΌΠ΅Π½Π½ΠΎΡΡΠΈ, Π½Π΅ ΠΎΡΠΌΠ΅ΡΠ΅Π½ΠΎ Π½ΠΈ ΠΎΠ΄Π½ΠΎΠ³ΠΎ ΡΠ»ΡΡΠ°Ρ Π²Π΅ΡΡΠΈΠΊΠ°Π»ΡΠ½ΠΎΠΉ ΠΏΠ΅ΡΠ΅Π΄Π°ΡΠΈ Π²ΠΈΡΡΡΠ½ΠΎΠΉ ΠΈΠ½ΡΠ΅ΠΊΡΠΈΠΈ. Π ΠΏΠ°ΡΠΎΠ³Π΅Π½Π΅Π·Π΅ ΡΡΠΆΠ΅Π»ΡΡ
ΠΎΡΠ»ΠΎΠΆΠ½Π΅Π½ΠΈΠΉ COVID-19 Ρ ΡΠΎΡΠΌΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ΠΌ ΡΡΠΆΠ΅Π»ΠΎΠ³ΠΎ ΠΎΡΡΡΠΎΠ³ΠΎ ΡΠ΅ΡΠΏΠΈΡΠ°ΡΠΎΡΠ½ΠΎΠ³ΠΎ Π΄ΠΈΡΡΡΠ΅ΡΡ-ΡΠΈΠ½Π΄ΡΠΎΠΌΠ°, ΠΏΠΎΠ»ΠΈΠΎΡΠ³Π°Π½Π½ΠΎΠΉ Π΄ΠΈΡΡΡΠ½ΠΊΡΠΈΠΈ Π²Π΅Π΄ΡΡΡΡ ΡΠΎΠ»Ρ ΠΈΠ³ΡΠ°ΡΡ ΡΡΠΏΠ΅ΡΠ²ΠΎΡΠΏΠ°Π»Π΅Π½ΠΈΠ΅ ΠΈ ΡΠΈΡΠΎΠΊΠΈΠ½ΠΎΠ²ΡΠΉ ΡΡΠΎΡΠΌ. Π ΡΡΠ°ΡΡΠ΅ Π² ΡΠ²ΡΠ·ΠΈ Ρ Π²ΠΈΡΡΡΠ½ΡΠΌ ΡΠ΅ΠΏΡΠΈΡΠΎΠΌ ΠΎΠ±ΡΡΠΆΠ΄Π°Π΅ΡΡΡ ΡΠΎΠ»Ρ Π³Π΅ΠΌΠΎΡΠ°Π³ΠΎΡΠΈΡΠ°ΡΠ½ΠΎΠ³ΠΎ Π»ΠΈΠΌΡΠΎΠ³ΠΈΡΡΠΈΠΎΡΠΈΡΠΎΠ·Π° ΠΊΠ°ΠΊ Π³ΠΈΠΏΠ΅ΡΠ²ΠΎΡΠΏΠ°Π»ΠΈΡΠ΅Π»ΡΠ½ΠΎΠ³ΠΎ ΡΠΈΠ½Π΄ΡΠΎΠΌΠ°, Ρ
Π°ΡΠ°ΠΊΡΠ΅ΡΠΈΠ·ΡΠ΅ΠΌΠΎΠ³ΠΎ ΡΡΠ»ΡΠΌΠΈΠ½Π°Π½ΡΠ½ΠΎΠΉ ΠΈ ΡΠ°ΡΠ°Π»ΡΠ½ΠΎΠΉ Π³ΠΈΠΏΠ΅ΡΡΠΈΡΠΎΠΊΠΈΠ½Π΅ΠΌΠΈΠ΅ΠΉ Ρ ΠΏΠΎΠ»ΠΈΠΎΡΠ³Π°Π½Π½ΠΎΠΉ Π½Π΅Π΄ΠΎΡΡΠ°ΡΠΎΡΠ½ΠΎΡΡΡΡ, ΡΠΎΠ»Ρ Π³ΠΈΠΏΠ΅ΡΡΠ΅ΡΡΠΈΡΠΈΠ½Π΅ΠΌΠΈΠΈ Π² ΠΏΡΠΎΠ³Π½ΠΎΠ·ΠΈΡΠΎΠ²Π°Π½ΠΈΠΈ ΠΈΡΡ
ΠΎΠ΄ΠΎΠ² ΡΡΠΆΠ΅Π»ΠΎΠ³ΠΎ ΡΠ΅ΠΏΡΠΈΡΠ°. ΠΠ±ΡΡΠΆΠ΄Π°ΡΡΡΡ Π³ΡΡΠΏΠΏΡ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² Π²ΡΡΠΎΠΊΠΎΠ³ΠΎ ΡΠΈΡΠΊΠ° ΡΠ°Π·Π²ΠΈΡΠΈΡ Π»Π΅ΡΠ°Π»ΡΠ½ΡΡ
ΠΈΡΡ
ΠΎΠ΄ΠΎΠ², Π° ΡΠ°ΠΊΠΆΠ΅ Π½Π΅ΠΎΠ±Ρ
ΠΎΠ΄ΠΈΠΌΠΎΡΡΡ Π°Π½ΡΠΈΠΊΠΎΠ°Π³ΡΠ»ΡΠ½ΡΠ½ΠΎΠΉ ΠΈ Π°Π½ΡΠΈΡΠΈΡΠΎΠΊΠΈΠ½ΠΎΠ²ΠΎΠΉ ΡΠ΅ΡΠ°ΠΏΠΈΠΈ Ρ Π±ΠΎΠ»ΡΠ½ΡΡ
COVID-19
Accessing of the mixed-valence states in the zinc meso-ferrocenylporphyrin: experimental and theoretical data.
The formation of the stable at room temperature mixed-valence state in the zinc 5,10,15,20-tetra(ferrocenyl)porphyrin has been investigated by UV-V1S-NIR, Mossbauer, NMR, electrochemical, and theoretical (DFT) methods. On the basis of experimental and theoretical data it has been concluded that the first oxidation process involves
Nondestructive control of Chernobyl hot particles behavior and migration of radionuclides in soil-plant system
Investigation of the bischofite gel reparative effect on the linear wound model
Introduction. The currently available information on the bischofite mineral pharmacodynamics makes it possible to assume that bischofite-based gels have wound-healing properties. Materials and methods. Experiments were performed on 36 male rats. Using a blade, a linear wound of 50 mm long was modeled. Animals were divided into 4 groups: 1) Control; 2) Bishofit (500 mg of gel with bischofite on the wound area for 7 days); 3) Actovegine (500 mg of Actovegine gel on the wound area for 7 days); 4) Contractubex (500 mg of contractubex gel on the wound area for 7 days). The wound healing effect of the drugs was evaluated through studying the physicomechanical properties, assessing the morphological picture, determining the concentration of hydroxyproline (HP) and calculating the ratio of types I and III collagen. Results. The strongest healing effect on the wound defect, significantly greater than that in the control (p Actovegine> Control> Contractubex. A similar trend is demonstrated by the morphological picture of tissues in the area of the wound defect. Conclusion. The study showed that the best results were obtained with external use of bischofite gel. Actovegine has a less significant, but quite pronounced reparative, effect on this model. The least satisfactory results were obtained when applying contractubex
Π€Π°ΠΊΡΠΎΡ ΡΠΎΠ½ ΠΠΈΠ»Π»Π΅Π±ΡΠ°Π½Π΄Π° ΠΈ ΠΌΠΈΠ΅Π»ΠΎΠΏΠ΅ΡΠΎΠΊΡΠΈΠ΄Π°Π·Π° ΠΊΠ°ΠΊ Π»Π°Π±ΠΎΡΠ°ΡΠΎΡΠ½ΡΠ΅ ΠΏΡΠ΅Π΄ΠΈΠΊΡΠΎΡΡ Π²ΡΠΆΠΈΠ²Π°Π΅ΠΌΠΎΡΡΠΈ ΠΏΡΠΈ ΡΡΠΆΠ΅Π»ΠΎΠΌ ΡΠ΅ΡΠ΅Π½ΠΈΠΈ COVID-19
Background. The severe acute respiratory syndrome of the SARS-CoV-2 virus-mediated coronavirus disease 2019 (COVID-19) highlighted the central role of immunothrombosis. Severe endothelial damage with the release of unusually large multimers of von Willebrand factor (vWF) and subsequent consumption of ADAMTS-13 is described during severe COVID-19. The activation of innate immune cells among which neutrophils contribute to the formation of extracellular neutrophil traps (NETs) and to the release of myeloperoxidase (MPO) potentially contributing to the spread of inflammation and microvascular thrombosis. Objective to evaluate the ability of vWF, ADAMTS-13 and MPO to predict in-hospital mortality in severe COVID-19 patients needing mechanical ventilation. Methods. We performed a one-center observational study of 79 severe COVID-19 patients entering intensive care unit for mechanical ventilation, examining vWF, ADAMTS-13 and MPO among other potential predictors for in-hospital death. Results. After multivariate analysis, vWF antigen (vWF:Ag) and MPO antigen (MPO:Ag) were finally the single two parameters which increasing values were independently associated with non-survival; vWF:Ag (U/dL): adjusted OR 3.360, 95% CI 1.5627.228, p = 0.0019; MPO:Ag (ng/ml): adjusted OR 1.062, 95% CI 1.0241.101, p = 0.0011. From these results a simplified mortality score was derived and patients categorized as having a score value higher or lower that the median value of the score: a high score value was associated with a lower cumulative survival rate (p 0.0001), 50% of the cases being dead at day 13 post-hospital admission. Conclusions. In severe COVID-19 necessitating mechanical ventilation, increasing values of MPO activity and of vWF antigen tested at admission are associated with poor survival.ΠΠ±ΠΎΡΠ½ΠΎΠ²Π°Π½ΠΈΠ΅. Π’ΡΠΆΠ΅Π»ΡΠΉ ΠΎΡΡΡΡΠΉ ΡΠ΅ΡΠΏΠΈΡΠ°ΡΠΎΡΠ½ΡΠΉ ΡΠΈΠ½Π΄ΡΠΎΠΌ, Π·Π°ΠΏΡΡΠΊΠ°Π΅ΠΌΡΠΉ Π²ΠΈΡΡΡΠΎΠΌ SARS-CoV-2, ΠΎΠ±ΠΎΠ·Π½Π°ΡΠΈΠ» ΡΠ΅Π½ΡΡΠ°Π»ΡΠ½ΡΡ ΡΠΎΠ»Ρ Π² ΠΏΠ°ΡΠΎΠ³Π΅Π½Π΅Π·Π΅ ΠΈΠΌΠΌΡΠ½ΠΎΡΡΠΎΠΌΠ±ΠΎΠ·Π°. ΠΡΠΈ ΡΡΠΆΠ΅Π»ΠΎΠΌ ΡΠ΅ΡΠ΅Π½ΠΈΠΈ COVID-19 ΠΎΠΏΠΈΡΠ°Π½ΠΎ ΠΌΠ°ΡΡΠΈΠ²Π½ΠΎΠ΅ ΠΏΠΎΠ²ΡΠ΅ΠΆΠ΄Π΅Π½ΠΈΠ΅ ΡΠ½Π΄ΠΎΡΠ΅Π»ΠΈΡ Ρ Π²ΡΡΠ²ΠΎΠ±ΠΎΠΆΠ΄Π΅Π½ΠΈΠ΅ΠΌ Π±ΠΎΠ»ΡΡΠΎΠ³ΠΎ ΠΊΠΎΠ»ΠΈΡΠ΅ΡΡΠ²Π° ΠΌΡΠ»ΡΡΠΈΠΌΠ΅ΡΠΎΠ² ΡΠ°ΠΊΡΠΎΡΠ° ΡΠΎΠ½ ΠΠΈΠ»Π»Π΅Π±ΡΠ°Π½Π΄Π° (vWF) ΠΈ ΠΏΠΎΡΠ»Π΅Π΄ΡΡΡΠΈΠΌ ΠΏΠΎΡΡΠ΅Π±Π»Π΅Π½ΠΈΠ΅ΠΌ ADAMTS-13. ΠΠΊΡΠΈΠ²Π°ΡΠΈΡ ΠΊΠ»Π΅ΡΠΎΠΊ Π²ΡΠΎΠΆΠ΄Π΅Π½Π½ΠΎΠ³ΠΎ ΠΈΠΌΠΌΡΠ½ΠΈΡΠ΅ΡΠ°, Π² ΡΠΎΠΌ ΡΠΈΡΠ»Π΅ Π½Π΅ΠΉΡΡΠΎΡΠΈΠ»ΠΎΠ², ΠΏΡΠΈΠ²ΠΎΠ΄ΠΈΡ ΠΊ ΠΎΠ±ΡΠ°Π·ΠΎΠ²Π°Π½ΠΈΡ Π½Π΅ΠΉΡΡΠΎΡΠΈΠ»ΡΠ½ΡΡ
Π²Π½Π΅ΠΊΠ»Π΅ΡΠΎΡΠ½ΡΡ
Π»ΠΎΠ²ΡΡΠ΅ΠΊ (NETs) ΠΈ Π²ΡΡΠ²ΠΎΠ±ΠΎΠΆΠ΄Π΅Π½ΠΈΡ ΠΌΠΈΠ΅Π»ΠΎΠΏΠ΅ΡΠΎΠΊΡΠΈΠ΄Π°Π·Ρ (ΠΠΠ), ΡΡΠΎ, Π² ΡΠ²ΠΎΡ ΠΎΡΠ΅ΡΠ΅Π΄Ρ, ΡΠΏΠΎΡΠΎΠ±ΡΡΠ²ΡΠ΅Ρ ΡΠ°ΡΠΏΡΠΎΡΡΡΠ°Π½Π΅Π½ΠΈΡ ΠΏΡΠΎΡΠ΅ΡΡΠΎΠ² Π²ΠΎΡΠΏΠ°Π»Π΅Π½ΠΈΡ ΠΈ ΡΡΠΎΠΌΠ±ΠΎΠ·Π° Π² ΠΌΠΈΠΊΡΠΎΡΠΎΡΡΠ΄ΠΈΡΡΠΎΠΌ ΡΡΡΠ»Π΅. Π¦Π΅Π»Ρ ΠΎΡΠ΅Π½ΠΈΡΡ ΠΏΡΠΎΠ³Π½ΠΎΡΡΠΈΡΠ΅ΡΠΊΡΡ ΡΠ΅Π½Π½ΠΎΡΡΡ ΠΊΠΎΠ½ΡΠ΅Π½ΡΡΠ°ΡΠΈΠΈ vWF, ADAMTS-13 ΠΈ MΠO Π² ΠΎΡΠ½ΠΎΡΠ΅Π½ΠΈΠΈ Π²Π½ΡΡΡΠΈΠ±ΠΎΠ»ΡΠ½ΠΈΡΠ½ΠΎΠΉ ΡΠΌΠ΅ΡΡΠ½ΠΎΡΡΠΈ Ρ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² Ρ ΡΡΠΆΠ΅Π»ΠΎΠΉ ΡΠΎΡΠΌΠΎΠΉ COVID-19, Π½ΡΠΆΠ΄Π°ΡΡΠΈΡ
ΡΡ Π² ΠΈΡΠΊΡΡΡΡΠ²Π΅Π½Π½ΠΎΠΉ Π²Π΅Π½ΡΠΈΠ»ΡΡΠΈΠΈ Π»Π΅Π³ΠΊΠΈΡ
(ΠΠΠ). ΠΠ΅ΡΠΎΠ΄Ρ. ΠΡΠΎΠ²Π΅Π΄Π΅Π½ΠΎ ΠΎΠ΄Π½ΠΎΡΠ΅Π½ΡΡΠΎΠ²ΠΎΠ΅ Π½Π°Π±Π»ΡΠ΄Π°ΡΠ΅Π»ΡΠ½ΠΎΠ΅ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠ΅ Ρ ΡΡΠ°ΡΡΠΈΠ΅ΠΌ 79 ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² Ρ ΡΡΠΆΠ΅Π»ΡΠΌ ΡΠ΅ΡΠ΅Π½ΠΈΠ΅ΠΌ COVID-19, Π½Π°Ρ
ΠΎΠ΄ΠΈΠ²ΡΠΈΡ
ΡΡ Π² ΠΎΡΠ΄Π΅Π»Π΅Π½ΠΈΠΈ ΠΈΠ½ΡΠ΅Π½ΡΠΈΠ²Π½ΠΎΠΉ ΡΠ΅ΡΠ°ΠΏΠΈΠΈ Π½Π° ΠΠΠ. Π£ Π²ΡΠ΅Ρ
ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² ΠΎΠΏΡΠ΅Π΄Π΅Π»ΡΠ»ΠΈΡΡ ΠΊΠΎΠ½ΡΠ΅Π½ΡΡΠ°ΡΠΈΠΈ vWF, ADAMTS-13 ΠΈ MΠO Π² ΡΡΠ²ΠΎΡΠΎΡΠΊΠ΅ ΠΊΡΠΎΠ²ΠΈ, Π° ΡΠ°ΠΊΠΆΠ΅ Π΄ΡΡΠ³ΠΈΠ΅ ΠΏΠΎΠΊΠ°Π·Π°ΡΠ΅Π»ΠΈ ΠΏΠΎΡΠ΅Π½ΡΠΈΠ°Π»ΡΠ½ΡΠ΅ ΠΏΡΠ΅Π΄ΠΈΠΊΡΠΎΡΡ Π²Π½ΡΡΡΠΈΠ±ΠΎΠ»ΡΠ½ΠΈΡΠ½ΠΎΠΉ ΡΠΌΠ΅ΡΡΠ½ΠΎΡΡΠΈ. Π Π΅Π·ΡΠ»ΡΡΠ°ΡΡ. ΠΡΡΠ΅ΠΌ ΠΏΡΠΎΠ²Π΅Π΄Π΅Π½ΠΈΡ ΠΌΠ½ΠΎΠ³ΠΎΡΠ°ΠΊΡΠΎΡΠ½ΠΎΠ³ΠΎ Π°Π½Π°Π»ΠΈΠ·Π° Π±ΡΠ»ΠΎ ΠΏΠΎΠΊΠ°Π·Π°Π½ΠΎ, ΡΡΠΎ ΡΠ²Π΅Π»ΠΈΡΠ΅Π½ΠΈΠ΅ ΠΊΠΎΠ½ΡΠ΅Π½ΡΡΠ°ΡΠΈΠΈ ΡΠ°ΠΊΠΈΡ
ΠΌΠ°ΡΠΊΠ΅ΡΠΎΠ², ΠΊΠ°ΠΊ Π°Π½ΡΠΈΠ³Π΅Π½ vWF (vWF:AΠ³) ΠΈ MΠO ΡΠ΅Π»ΠΎΠ²Π΅ΠΊΠ° (MΠO:AΠ³), Π΄ΠΎΡΡΠΎΠ²Π΅ΡΠ½ΠΎ ΠΈ Π½Π΅Π·Π°Π²ΠΈΡΠΈΠΌΠΎ ΡΠ²ΡΠ·Π°Π½ΠΎ Ρ Π²ΡΡΠΎΠΊΠΎΠΉ Π²Π΅ΡΠΎΡΡΠ½ΠΎΡΡΡΡ ΡΠΌΠ΅ΡΡΠ½ΠΎΡΡΠΈ; vWF:AΠ³ (ΠΠ/Π΄Π»): ΡΠΊΠΎΡΡΠ΅ΠΊΡΠΈΡΠΎΠ²Π°Π½Π½ΠΎΠ΅ ΠΠ¨ 3,360; 95%-ΠΉ ΠΠ 1,5627,228; Ρ = 0,0019; MΠO:AΠ³ (Π½Π³/ΠΌΠ»): ΡΠΊΠΎΡΡΠ΅ΠΊΡΠΈΡΠΎΠ²Π°Π½Π½ΠΎΠ΅ ΠΠ¨ 1,062; 95%-ΠΉ ΠΠ 1,0241,101; Ρ = 0,0011. ΠΠ° ΠΎΡΠ½ΠΎΠ²Π°Π½ΠΈΠΈ ΡΡΠΈΡ
ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΠΎΠ² Π±ΡΠ» ΠΏΠΎΠ»ΡΡΠ΅Π½ ΡΠΏΡΠΎΡΠ΅Π½Π½ΡΠΉ ΠΏΠΎΠΊΠ°Π·Π°ΡΠ΅Π»Ρ ΡΠΌΠ΅ΡΡΠ½ΠΎΡΡΠΈ, ΠΈ ΠΏΠ°ΡΠΈΠ΅Π½ΡΡ Π±ΡΠ»ΠΈ ΠΊΠ»Π°ΡΡΠΈΡΠΈΡΠΈΡΠΎΠ²Π°Π½Ρ ΠΊΠ°ΠΊ ΠΈΠΌΠ΅ΡΡΠΈΠ΅ Π·Π½Π°ΡΠ΅Π½ΠΈΡ Π΄Π°Π½Π½ΠΎΠ³ΠΎ ΠΏΠΎΠΊΠ°Π·Π°ΡΠ΅Π»Ρ Π²ΡΡΠ΅ ΠΈΠ»ΠΈ Π½ΠΈΠΆΠ΅ ΠΌΠ΅Π΄ΠΈΠ°Π½Π½ΠΎΠ³ΠΎ: Π²ΡΡΠΎΠΊΠΎΠ΅ Π·Π½Π°ΡΠ΅Π½ΠΈΠ΅ ΠΏΠΎΠΊΠ°Π·Π°ΡΠ΅Π»Ρ Π±ΡΠ»ΠΎ ΡΠ²ΡΠ·Π°Π½ΠΎ Ρ Π±ΠΎΠ»Π΅Π΅ Π½ΠΈΠ·ΠΊΠΎΠΉ ΠΊΡΠΌΡΠ»ΡΡΠΈΠ²Π½ΠΎΠΉ Π²ΡΠΆΠΈΠ²Π°Π΅ΠΌΠΎΡΡΡΡ (p 0,0001), Π² 50% ΡΠ»ΡΡΠ°Π΅Π² ΡΠΌΠ΅ΡΡΡ Π½Π°ΡΡΡΠΏΠ°Π»Π° Π½Π° 13-Π΅ ΡΡΡ Π³ΠΎΡΠΏΠΈΡΠ°Π»ΠΈΠ·Π°ΡΠΈΠΈ. ΠΡΠ²ΠΎΠ΄Ρ. ΠΡΠΈ ΡΡΠΆΠ΅Π»ΠΎΠΌ ΡΠ΅ΡΠ΅Π½ΠΈΠΈ COVID-19, ΡΡΠ΅Π±ΡΡΡΠ΅ΠΌ ΠΠΠ, ΠΏΠΎΠ²ΡΡΠ΅Π½Π½ΡΠ΅ ΠΊΠΎΠ½ΡΠ΅Π½ΡΡΠ°ΡΠΈΠΈ ΠΠΠ ΠΈ vWF Π½Π° ΠΌΠΎΠΌΠ΅Π½Ρ ΠΏΠΎΡΡΡΠΏΠ»Π΅Π½ΠΈΡ ΠΊΠΎΡΡΠ΅Π»ΠΈΡΡΡΡ Ρ ΠΏΠ»ΠΎΡ
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