A Study of Panel Loads and Centers of Pressure of Three Different Cruciform Aft-Tail Control Surfaces of a Wingless Missile from Mach 1.60 to 3.70

An investigation was made of the forces and moments on the cruciform aft-tail control surfaces of a wingless missile model to determine the variation of panel load and center of pressure with angle of attack, tail deflection, model roll angle, and Mach number. Also, a limited force-moment and surface-pressure investigation was made on a noncircular aft end. These investigations were made in a unitary plan wind tunnel at Mach numbers of 1.60, 2.36, and 3.70 and at a Reynolds number per meter of 6,600,000. The cruciform aft-tail results indicate very little variation in the center of pressure for the highly loaded windward tail. The noncircular aft-end test results indicate no significant effect of the fin unporting on the fin loads

Extended-release morphine sulfate in treatment of severe acute and chronic pain

Morphine is the archetypal opioid analgesic. Because it is a short-acting opioid, its use has been limited to the management of acute pain. The development of extended-release formulations have resulted in the increased utilization of morphine in chronic pain conditions. This review documents the history of morphine use in pain treatment, and describes the metabolism, pharmacodynamics, formulations, and efficacy of the currently available extended-release morphine medications

Effects of Reynolds number and model support on the supersonic aerodynamic chacteristics of a 140 deg-included-angle cone

An investigation has been made in the Langley Unitary Plan wind tunnel to determine the effects of Reynolds number and sting-support interference on the static aerodynamic characteristics of a 140 deg-included-angle cone. Base pressures and forces and moments of the model were measured at Mach numbers of 1.50, 2.00, 2.94, and 4.00 for ratios of sting diameter to model diameter that varied from 0.125 to 0.500 through an angle-of-attack range from about minus 4 deg to 13 deg. The Reynolds number, based on model diameter 4.80 in. was varied from 161,000 to 415,000

Chronic opioid analgesic usage post‐kidney transplantation and clinical outcomes

Chronic opioid usage ( COU ) is common among patients with end‐stage renal disease ( ESRD ) qualified for kidney transplantation and associated with inferior post‐transplant outcomes. The magnitude of COU after kidney transplantation and its impact on transplant outcomes remain unknown. We performed a single‐center retrospective study aimed to describe the prevalence of COU during the first year, to identify the predictors of COU and to determine the impact of COU on post‐transplant outcomes including the rates of hospitalization and acute rejection during the first year, as well as long‐term patient and graft survival. Among 1045 kidney transplant patients, 119 (11.4%) had required continued outpatient prescription of opioid analgesics during the first year after kidney transplantation, mostly for non‐surgery‐related pain (85%). A positive history of COU prior to transplantation was the strongest predictor of COU in the first year post‐transplantation (adjusted odds ratio [ AOR ] 4.31, p < 0.001). Patients with COU had more often hospital admission during the first year ( AOR 2.48, p = 0.001, for 1 or 2 admissions, and AOR 6.03, p < 0.001 for ≥3 admissions), but similar rate of acute rejection (19.3% vs. 15.7%, p = 0.31). During long‐term follow‐up, however, the patient and/or death‐censored kidney survival was not different. COU early post‐kidney transplantation, when clinically indicated and properly supervised, does not appear to affect the risk of death and death‐censored graft failure.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/108587/1/ctr12414.pd

Morphinofobia: the situation among the general population and health care professionals in North-Eastern Portugal

<p>Abstract</p> <p>Background</p> <p>Morphinofobia among the general population (GP) and among health care professionals (HP) is not without danger for the patients: it may lead to the inappropriate management of debilitating pain. The aim of our study was to explore among GP and HP the representation and attitudes concerning the use of morphine in health care.</p> <p>Methods</p> <p>A cross-sectional study was done among 412 HP (physicians and nurses) of the 4 hospitals and 10 community health centers of Beira Interior (Portugal)and among 193 persons of the GP randomly selected in public places. Opinions were collected through a translated self-administered questionnaire.</p> <p>Results</p> <p>A significant difference of opinion exists among GP and HP about the use of morphine. The word morphine first suggests drug to GP (36,2%) and analgesia to HP (32,9%.). The reasons for not using morphine most frequently cited are: for GP morphine use means advanced disease (56%), risk of addiction (50%), legal requirements (49,7%); for HP it means legal risks (56,3%) and adverse side effects of morphine such as somnolence - sedation (30,5%) The socio-demographic situation was correlated with the opinions about the use of morphine.</p> <p>Conclusions</p> <p>False beliefs about the use of morphine exist among the studied groups. There seems to be a need for developing information campaigns on pain management and the use of morphine targeting. Better training and more information of HP might also be needed.</p