12 research outputs found
QT PRODACT: Comparison of Non-clinical Studies for Drug-Induced Delay in Ventricular Repolarization and Their Role in Safety Evaluation in Humans
Flunarizine rescues reduced lifespan in CLN3 triple knock-out Caenorhabditis elegans model of batten disease
The Relative Role of Soluble Guanylyl Cylase Dependent and Independent Pathways in Nitric Oxide Inhibition of Platelet Aggregation Under Flow
Phospholipase A2 as a Molecular Determinant of Store-Operated Calcium Entry
Rosado J. (eds).Activation of phospholipases A2 (PLA2) leads to the generation of biologically active lipid products that can affect numerous cellular events. Ca2+-independent PLA2 (iPLA2), also called group VI phospholipase A2, is one of the main types forming the superfamily of PLA2. Beside of its role in phospholipid remodeling, iPLA2 has been involved in intracellular Ca2+ homeostasis regulation. Several studies proposed iPLA2 as an essential molecular player of store operated Ca2+ entry (SOCE) in a large number of excitable and non-excitable cells. iPLA2 activation releases lysophosphatidyl products, which were suggested as agonists of store operated calcium channels (SOCC) and other TRP channels. Herein, we will review the important role of iPLA2 on the intracellular Ca2+ handling focusing on its role in SOCE regulation and its implication in physiological and/or pathological processes.This work was supported by Spanish Ministry of Economy and Competitiveness [BFU2013-45564-C2-1-P and BFU2013-45564-C2-2-P]; Institute of Carlos III and Cardiovascular Network “RIC” [RD12/0042/0041;PI12/00941]; and from the Andalusia Government [PI-0108-2012; P10-CVI-6095]. A.D.R. is supported by ITRIBIS FP-7-REGPOT.Peer reviewe