PUBLIC SCHOOL PRINCIPALS’ ATTITUDES REGARDING THE CLASSROOM PARTICIPATION OF STUDENTS WITH AUTISM WHO EXHIBIT CHALLENGING BEHAVIOR

Students with autism spectrum disorder (ASD) present challenges for principals supervising both general and special education teachers. Evidence-based practices designed to address the challenging behavior and academic needs of this population exists, but there are numerous contextual factors that affect the ability of principals to effectively assist their teachers in implementation. The purpose of this research was to examine the relationship between principal leader’s demographic characteristics, the influence of contextual factors, and leadership attitudes that affect their development and priorities for their schools. The implementation science framework and collective impact theory was investigated as a conceptual framework to analyze these critical research areas. Elementary principals responded to a researcher-designed survey instrument to identify contextual factors and priorities for development. Information was analyzed using one-way analysis of variance tests (ANOVA) and survey response patterns. Findings will provide direct guidance for principal development and leadership practices

Effects of Contact Load on the Fretting Fatigue Behavior of IN-100 at Elevated Temperature

This thesis studied the effects of contact load of 8006 N on the fretting fatigue behavior of IN-100 at an elevated temperature of 600°C. First, S-N curves were created for a range of applied axial stresses at an identical stress ratio of 0.03 at 8006 N. A condition of partial slip condition necessary to fretting fatigue was verified by generating hysteresis loops, plotting shear force against axial stress. The half-contact width and the crack initiation location were determined for all of the fretting specimens using optical and scanning electron microscopes. The contact widths were consistent with expected analytical values and the crack initiation location was at the trailing edge of contact for all fretting specimens at a mean angle of 45°. This study compared the fretting results at higher contact load (8006 N) to similar results from previous studies of IN-100 at lower contact load (4003 N) with an identical microstructure at an elevated temperature of 600°C as well as to previous room temperature testing. It was found that fretting fatigue at higher contact load drastically reduces the cycles to failure compared to fretting fatigue at elevated temperature with a lesser contact load. While the higher temperature environment allowed a longer initiation and crack propagation time, this was quickly negated by the increase in the contact load. The development of glaze oxide films and temperature induced softening or plasticity were both found to act as crack closure mechanisms in another nickel-based superalloy, IN-718, when fatigued in the high temperature environment. This glaze oxide reduces the coefficient of friction between contact surfaces, an important factor in fretting fatigue, and is also observed to be present in high temperature studies of IN-100

Kinetics and Mechanisms of Oxidation of Hemoprotein Model Compounds

The kinetics of reaction of oxyheme complexes with dithionite ion and with deoxyheme were studied. Because rates of autooxidation of oxyheme complexes were inversly proportional to oxygen pressure and proportional to the square of the total heme concentration, it was concluded that the reaction proceeds through Heme- 00-Heme as suggested by Cohen and Caughey. The direct reaction of dithionite ion with oxyheme complexes accords with the Fe+o 2- · formulation of the iron-oxygen bond

Kinetics and Mechanisms of Oxidation of Hemoprotein Model Compounds

The kinetics of reaction of oxyheme complexes with dithionite ion and with deoxyheme were studied. Because rates of autooxidation of oxyheme complexes were inversly proportional to oxygen pressure and proportional to the square of the total heme concentration, it was concluded that the reaction proceeds through Heme- 00-Heme as suggested by Cohen and Caughey. The direct reaction of dithionite ion with oxyheme complexes accords with the Fe+o 2- · formulation of the iron-oxygen bond

Corals Use Similar Immune Cells and Wound-Healing Processes as Those of Higher Organisms

Sessile animals, like corals, frequently suffer physical injury from a variety of sources, thus wound-healing mechanisms that restore tissue integrity and prevent infection are vitally important for defence. Despite the ecological importance of reef-building corals, little is known about the cells and processes involved in wound healing in this group or in phylogenetically basal metazoans in general

Microdeletion of 6q16.1 encompassing EPHA7 in a child with mild neurological abnormalities and dysmorphic features: case report

<p>Abstract</p> <p>Background</p> <p>Of the fewer than 100 cases reported within the literature of constitutional deletions involving the long arm of chromosome 6, only five have been characterized using high-resolution microarray analysis. Reported 6q deletion patients show a high incidence of mental retardation, ear anomalies, hypotonia, and postnatal growth retardation.</p> <p>Results</p> <p>We report a 16-month-old male presenting with developmental delay and dysmorphic features who was found by array-based comparative genomic hybridization (aCGH) to have a ~2.16 Mb <it>de novo </it>deletion within chromosome band 6q16.1 that encompasses only two genes. Expression studies of the mouse homologue of one of the genes, the ephrin receptor 7 gene (<it>EPHA7</it>), have shown the gene functions during murine embryogenesis to form cortical domains, determine brain size and shape, and play a role in development of the central nervous system (CNS).</p> <p>Discussion</p> <p>Our results suggest that deletion of <it>EPHA7 </it>plays a role in the neurologic and dysmorphic features, including developmental delay, hypotonia, and ear malformations, observed in some 6q deletion patients.</p

Estimates of Critical Power and Anaerobic Work Capacity from a Single, All-Out Test of Less than 3-Min

The purpose of this study was to determine if Critical Power (CP) and Anaerobic Work Capacity (AWC) could be estimated from a single, all-out test of less than 3-min. Twenty-eight subjects (mean ± SD: age 23.3 ± 3.3 years, body mass 71.6 ± 16 kg) performed an incremental cycle ergometer test to exhaustion to determine peak oxygen consumption rate and heart rate peak. The 3-min all-out test was used to determine the criterion and six estimated values of CP and AWC. The criterion critical power (CP180) and anaerobic work capacity (AWC180) values were determined from the 3-min all-out test and were expressed as 30-s averages (155-180-s). The six estimated CP and AWC values were calculated from 30-s averages at decreasing 10-s intervals from 145 to 170-s (CP170 and AWC170), 135 to 160-s (CP160 and AWC160), 125 to 150-s (CP150 and AWC150), 115 to 140-s (CP140 and AWC140), 105 to 130-s (CP130 and AWC130), and 95 to 120-s (CP120 and AWC120). Mean differences, total error, constant error, standard error of the estimate, and correlations were used to compare the criterion to the estimated CP and AWC values. The results of the present study indicated that 150-s was the shortest test duration that resulted in non-significant differences between the criterion (CP180 and AWC180) and estimated CP (CP150) and AWC (AWC150) values. The subsequent validation analyses showed that there were close agreements for the estimated CP150 and AWC150 versus the criterion (CP180 and AWC180) values. Therefore, the current findings indicated that estimates of CP and AWC were not affected by shortening the test by 30-s. Reducing the length of the test to 2.5 minutes provides a less strenuous, yet valid protocol for estimating CP and AWC

Sex-specific and developmental expression of Dmrt genes in the starlet sea anemone, Nematostella vectensis

BACKGROUND: The molecular mechanisms underlying sex determination and differentiation in animals are incredibly diverse. The Dmrt (doublesex and mab-3 related transcription factor) gene family is an evolutionary ancient group of transcription factors dating to the ancestor of metazoans that are, in part, involved in sex determination and differentiation in numerous bilaterian animals and thus represents a potentially conserved mechanism for differentiating males and females dating to the protostome-deuterostome ancestor. Recently, the diversity of this gene family throughout animals has been described, but the expression and potential function for Dmrt genes is not well understood outside the bilaterians. RESULTS: Here, we report sex- and developmental-specific expression of all 11 Dmrts in the starlet sea anemone Nematostella vectensis. Nine out of the eleven Dmrts showed significant differences in developmental expression, with the highest expression typically in the adult stage and, in some cases, with little or no expression measured during embryogenesis. When expression was compared in females and males, seven of the eleven Dmrt genes had significant differences in expression with higher expression in males than in females for six of the genes. Lastly, expressions of two Dmrt genes with differential expression in each sex are located in the mesenteries and into the pharynx in polyps. CONCLUSIONS: Our results show that the phylogenetic diversity of Dmrt genes in N. vectensis is matched by an equally diverse pattern of expression during development and in each sex. This dynamic expression suggests multiple functions for Dmrt genes likely present in early diverging metazoans. Detailed functional analyses of individual genes will inform hypotheses regarding the antiquity of function for these transcription factors.NTK was supported by the NSF Ocean Sciences Postdoctoral Fellowship, Award Number OCE-1323652, and Award Number 1012629 from the Burroughs Wellcome Fund Postdoctoral Enrichment Program. AMR was supported by Award Number F32HD062178 from the Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD) during a postdoctoral fellowship in Dr. Ann Tarrant's laboratory (WHOI) and Award Number R15GM114740 from National Institute of General Medicine (NIGMS). VS and EGK were supported by Binational Science Foundation Grant 2013119. AMR acknowledges generous funding from the University of North Carolina at Charlotte. (OCE-1323652 - NSF Ocean Sciences Postdoctoral Fellowship; 1012629 - Burroughs Wellcome Fund Postdoctoral Enrichment Program; F32HD062178 - Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD); R15GM114740 - National Institute of General Medicine (NIGMS); 2013119 - Binational Science Foundation; University of North Carolina at Charlotte)Published versio