754 research outputs found

    BMED 615.01: Molecular Pharmacology

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    BCH 294.01: Introductory Biochemistry Seminar

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    An Integrated Approach to Mobile Treatment of Flowback Water from Shale Gas Production

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    Advancements in horizontal drilling and hydraulic fracturing technologies and methods have resulted in tight shale formations becoming viable for oil and gas production. A necessary resource for any hydraulic fracturing project is fresh water to form the fracturing fluid. Most of the used water is discharged in the form of a flowback wastewater. In principle, the flowback wastewater can be treated and reused to reduce freshwater consumption. The objective of this research is to develop a framework for the logistics and scheduling of a mobile treatment system for multiple producing wells. Several treatment technologies were studied, including coagulation/ultrafiltration, lime softening, and membrane treatment. In order to perform a case study on Marcellus well data, thermal membrane distillation technology (TMD) was chosen due to its modularity and compatibility for use in a mobile rig. An optimization approach was used in order to determine the number of membrane units needed at each well for each of the twenty-eight days. Results show that the use of TMD for flowback treatment is economically competitive with conventional disposal methods. The application of this framework can be scaled to any number of wells, allowing for efficient and accurate allocation of mobile units to meet desired treatment thresholds

    PHAR 329.01: Microbes and Medicines

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    Open Lumbosacral Dislocation: A Case Report

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    Open injuries in the lumbar spine are rare. We describe a 20-year-old woman who presented with persistent weaknesses due to an associated lumbar plexus injury. She underwent surgical treatment of lumbosacral dislocation with prompt reduction with debridement and stabilization. At 7 months postoperatively, her symptoms showed signs of recovery. We believe the immediate reduction of the dislocation prevented permanent neurological injury, and stabilization helped healing and early mobilization. In keeping with the classical teaching of open fracture treatment, prioritizing early initiation of intravenous antibiotics and prompt debridement and stabilization may have helped decrease the long-term morbidity and overall sequelae of this unique and devastating injury

    The anatomy of exhumed river-channel belts: Bedform to belt‐scale river kinematics of the Ruby Ranch Member, Cretaceous Cedar Mountain Formation, Utah, USA

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    Many published interpretations of ancient fluvial systems have relied on observations of extensive outcrops of thick successions. This paper, in contrast, demonstrates that a regional understanding of palaeoriver kinematics, depositional setting and sedimentation rates can be interpreted from local sedimentological measurements of bedform and barform strata. Dune and bar strata, channel planform geometry and bed topography are measured within exhumed fluvial strata exposed as ridges in the Ruby Ranch Member of the Cretaceous Cedar Mountain Formation, Utah, USA. The ridges are composed of lithified stacked channel belts, representing at least five or six re‐occupations of a single‐strand channel. Lateral sections reveal well‐preserved barforms constructed of subaqueous dune cross‐sets. The topography of palaeobarforms is preserved along the top surface of the outcrops. Comparisons of the channel‐belt centreline to local palaeotransport directions indicate that channel planform geometry was preserved through the re‐occupations, rather than being obscured by lateral migration. Rapid avulsions preserved the state of the active channel bed and its individual bars at the time of abandonment. Inferred minimum sedimentation durations for the preserved elements, inferred from cross‐set thickness distributions and assumed bedform migration rates, vary within a belt from one to ten days. Using only these local sedimentological measurements, the depositional setting is interpreted as a fluvial megafan, given the similarity in river kinematics. This paper provides a systematic methodology for the future synthesis of vertical and planview data, including the drone‐equipped 2020 Mars Rover mission, to exhumed fluvial and deltaic strata

    A Novel, Contactless, Portable “Spot-Check” Device Accurately Measures Respiratory Rate

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    Respiratory rate (RR) is an important vital sign used in the assessment of acutely ill patients. It is also used as to predict serious deterioration in a patient's clinical condition. Convenient electronic devices exist for measurement of pulse, blood pressure, oxygen saturation and temperature. Although devices which measure RR exist, none has entered everyday clinical practice. We developed a contactless portable respiratory rate monitor (CPRM) and evaluated the agreement in respiratory rate measurements between existing methods and our new device. The CPRM uses thermal anemometry to measure breath signals during inspiration and expiration. RR data were collected from 52 healthy adult volunteers using respiratory inductance plethysmography (RIP) bands (established contact method), visual counting of chest movements (established non-contact method) and the CPRM (new method), simultaneously. Two differently shaped funnel attachments were evaluated for each volunteer. Data showed good agreement between measurements from the CPRM and the gold standard RIP, with intra-class correlation coefficient (ICC): 0.836, mean difference 0.46 and 95% limits of agreement of -5.90 to 6.83. When separate air inlet funnels of the CPRM were analysed, stronger agreement was seen with an elliptical air inlet; ICC 0.908, mean difference 0.37 with 95% limits of agreement -4.35 to 5.08. A contactless device for accurately and quickly measuring respiratory rate will be an important triage tool in the clinical assessment of patients. More testing is needed to explore the reasons for outlying measurements and to evaluate in the clinical setting

    Directed Energy Planetary Defense

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    Directed Energy (DE) systems offer the potential for true planetary defense from small to km class threats. Directed energy has evolved dramatically recently and is on an extremely rapid ascent technologically. It is now feasible to consider DE systems for threats from asteroids and comets. DE-STAR (Directed Energy System for Targeting of Asteroids and exploration) is a phased-array laser directed energy system intended for illumination, deflection and compositional analysis of asteroids [1]. It can be configured either as a stand-on or a distant stand-off system. A system of appropriate size would be capable of projecting a laser spot onto the surface of a distant asteroid with sufficient flux to heat a spot on the surface to approximately 3,000 K, adequate to vaporize solid rock. Mass ejection due to vaporization creates considerable reactionary thrust to divert the asteroid from its orbit. DESTARLITE is a smaller stand-on system that utilizes the same technology as the larger standoff system, but with a much smaller laser for a dedicated mission to a specific asteroid. DESTARLITE offers a very power and mass efficient approach to planetary defense. As an example, a DE-STARLITE system that fits within the mass and size constraints of the Asteroid Redirect Mission (ARM) system in a small portion of the SLS block 1 launch capability is capable of deflecting an Apophis class (325 m diameter) asteroid with sufficient warning. A DESTARLITE using the full SLS block 1 launch mass can deflect any known threat

    Evaluation of Content and Accessibility of Orthopaedic Trauma Fellowship Websites

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    Background: Residents frequently use the internet to find material on fellowship programs. The Orthopaedic Trauma Association (OTA) website serves as a central hub for information on an orthopaedic trauma fellowship (OTF). This study aims to evaluate the accessibility, content, and perceived importance of OTF websites. Methods: We reviewed the 49 OTFs accredited by the OTA fellowship database as of January 2014. We searched for corresponding OTF websites by using the provided OTA hyperlinks and conducting a separate Google search of program location and institution. Links to websites of general orthopaedic programs were not counted. Content of OTF websites was analyzed by noting the presence or absence of specific items in fellow education (11 items) and recruitment (5 items). Results: Of 49 OTFs, a total of 39 (80%) websites specific to the fellowship were identified by searching the OTA database and Google browser. Seven (14%) programs listed on the OTA database provided links directly to fellowship programs. Most programs (28; 57%) did not provide links to specific OTFs or provided non-functional links on the OTA website. Of the 39 accessible OTF websites, a total of 24 (61%) had complete information regarding recruitment and 14 (36%) provided complete details on education. Conclusions: Most accredited OTFs do not adequately use the internet to provide easily accessible and complete information. Further details (especially regarding the role, education, and schedule) would help prospective candidates in thoroughly evaluating programs. The discrepancy in content and accessibility can hinder prospective fellows from appropriately investigating fellowship programs

    Comparison of Intraoperative Fluoroscopy to Postoperative Weight-Bearing Radiographs Obtained 4 to 6 Weeks After Bunion Repair With A Chevron Osteotomy

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    Background: During operative treatment of bunions, an attempt is made to correct the hallux valgus angle (HVA) and the intermetatarsal angle (IMA). In this study, the HVA and the IMA were measured using intraoperative C-arm fluoroscopic images obtained during surgical treatment of a bunion with chevron osteotomy. These angles were again measured using weight-bearing radiographs obtained 4 to 6 weeks postoperatively. Methods: At our institution, we reviewed medical records of patients who underwent a bunion repair with chevron osteotomy between January 2013 and October 2017. A total of 26 feet from 24 patients were included. Three authors (ALP, TMH, and RAM) measured the HVA and IMA using intraoperative fluoroscopic images and postoperative weight-bearing radiographs (4 measurements per foot; total, 104 measurements). The authors were blinded to their previous angular measurements and to measurements made by the others. An intraclass correlation coefficient was calculated for the HVA and IMA measurements between groups (ie, intraoperative fluoroscopic images and postoperative radiographs) to determine interobserver reliability. We compared the angles measured by the authors between groups and used a paired t test for statistical evaluation. Results: Interobserver difference of the HVA and IMA was low between intraoperative fluoroscopic images and postoperative weight-bearing radiographs (0.98 and 0.79; 0.78 and 0.95, respectively). The measured IMAs were relatively consistent between groups (6.21° and 6.37°, respectively); only two patients had a difference \u3e 3°. There was a greater difference in HVAs between groups (11.5° and 14.2°, respectively). In 11 feet, the HVA was \u3e 5° (range, 5.3-12.7°) in the postoperative radiograph compared to the fluoroscopic image. In one foot, we noted a 7° decrease of the HVA on the postoperative radiograph. The average difference of HVA between groups was 2.6° (P \u3c 0.0001), whereas the IMA was 0.16° (P = 0.002). Conclusions: Interobserver measurements of the HVA and IMA were reliable on both the intraoperative fluoroscopic images and the postoperative weightbearing radiographs. The IMA was similar between groups; however, the HVA was often greater on the postoperative weight-bearing radiographs
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