186 research outputs found

    Solid-State and Gas-Phase Structures and Energetic Properties of the Dangerous Methyl and Fluoromethyl Nitrates

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    Reichel M, Krumm B, Vishnevskiy Y, et al. Solid-State and Gas-Phase Structures and Energetic Properties of the Dangerous Methyl and Fluoromethyl Nitrates. Angewandte Chemie (International ed. in English). 2019;58(51):18557-18561.An improved synthesis of the simplest nitric acid ester, methyl nitrate, and a new synthesis of fluoromethyl nitrate use the metathesis of the corresponding iodomethanes with silver nitrate. Both compounds were identified by spectroscopy and the structures determined for in situ grown crystals by X-ray diffraction as well as in the gas phase by electron diffraction. Fluorination leads to structures with shorter C-O and N-O bonds, has an energetically destabilizing effect and increases friction sensitivity, but decreases detonation performance. © 2019 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA

    Oxytocin and Vasopressin Involved in Restraint Water-Immersion Stress Mediated by Oxytocin Receptor and Vasopressin 1b Receptor in Rat Brain

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    Aims: Vasopressin (AVP) and oxytocin (OT) are considered to be related to gastric functions and the regulation of stress response. The present study was to study the role of vasopressinergic and oxytocinergic neurons during the restraint waterimmersion stress. Methods: Ten male Wistar rats were divided into two groups, control and RWIS for 1h. The brain sections were treated with a dual immunohistochemistry of Fos and oxytocin (OT) or vasopressin (AVP) or OT receptor or AVP 1b receptor (V1bR). Results: (1) Fos-immunoreactive (Fos-IR) neurons dramatically increased in the hypothalamic paraventricular nucleus (PVN), the supraoptic nucleus (SON), the neucleus of solitary tract (NTS) and motor nucleus of the vagus (DMV) in the RWIS rats; (2) OT-immunoreactive (OT-IR) neurons were mainly observed in the medial magnocellular part of the PVN and the dorsal portion of the SON, while AVP-immunoreactive (AVP-IR) neurons mainly distributed in the magnocellular part of the PVN and the ventral portion of the SON. In the RWIS rats, Fos-IR neurons were indentified in 31 % of OT-IR neurons and 40 % of AVP-IR neurons in the PVN, while in the SON it represented 28%, 53 % respectively; (3) V 1bR-IR and OTR-IR neurons occupied all portions of the NTS and DMV. In the RWIS rats, more than 10 % of OTR-IR and V1bR-IR neurons were activated in the DMV, while lower ratio in the NTS. Conclusion: RWIS activates both oxytocinergic and vasopressinergic neurons in the PVN and SON, which may project to th

    A comprehensive overview of radioguided surgery using gamma detection probe technology

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    The concept of radioguided surgery, which was first developed some 60 years ago, involves the use of a radiation detection probe system for the intraoperative detection of radionuclides. The use of gamma detection probe technology in radioguided surgery has tremendously expanded and has evolved into what is now considered an established discipline within the practice of surgery, revolutionizing the surgical management of many malignancies, including breast cancer, melanoma, and colorectal cancer, as well as the surgical management of parathyroid disease. The impact of radioguided surgery on the surgical management of cancer patients includes providing vital and real-time information to the surgeon regarding the location and extent of disease, as well as regarding the assessment of surgical resection margins. Additionally, it has allowed the surgeon to minimize the surgical invasiveness of many diagnostic and therapeutic procedures, while still maintaining maximum benefit to the cancer patient. In the current review, we have attempted to comprehensively evaluate the history, technical aspects, and clinical applications of radioguided surgery using gamma detection probe technology

    La gestione e la valorizzazione dei musei della ceramica delle due sponde dell'Adriatico - The management and the qualification of museums devoted to ceramics of the two shores of the Adriatic

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    l'obiettivo conoscitivo specifico ha riguardato l’analisi del grado di evoluzione in senso manageriale delle istituzioni museali indagate . E’ apparso infatti significativo poter svolgere una simile riflessione con riferimento ad un campione che è omogeneo sotto il profilo settoriale e che è composto da musei che hanno rapporti tra di loro. Ossia, un campione nell’ambito del quale vi è una rilevante circolazione di idee e di informazioni. Pur non potendo infatti affermarsi che si sia in presenza di una rete formalizzata, nondimeno si tratta di musei che, sia pure in modo diverso, hanno aderito ad un medesimo progetto internazionale ed a carattere pluriennale, testimoniando in tal modo l’esistenza di legami personali ed istituzionali. Risulta dunque interessante verificare come, in un contesto connotato da elementi di omogeneità e di circolazione delle idee e delle informazioni, i musei stiano definendo i propri percorsi di miglioramento gestionale ed organizzativo. Il campione sottoposto ad indagine consente inoltre di realizzare tali riflessioni in un’ottica di comparazione internazionale, riferendosi a musei situati in Paesi posti sulle due sponde dell’Adriatico. Oltre ai principali musei della ceramica del versante centro-orientale del nostro Paese, sono infatti state analizzate esperienze gestionali ed organizzative proprie di musei della Serbia (Belgrado) e della Croazia (Zagabria, Pola e Zara). Appare quindi interessante verificare anche quali siano i gradi di omogeneità e di eterogeneità dei modelli organizzativi e gestionali assunti a riferimento in contesti nazionali ed istituzionali differenti, provenienti altresì da esperienze storiche e sociali assai diverse. A tale scopo, gli aspetti che sono stati indagati nell’ambito di questo paragrafo saranno: la forma di gestione prescelta; i sistemi di misurazione adottati; il grado di sviluppo del sistema di programmazione e controllo; l’orientamento verso i visitatori e le relative modalità

    Formation a la detection du ganglion sentinelle dans le cancer du sein et le melanome Villejuif, 1-2 fevrier 2001

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    SIGLEAvailable from INIST (FR), Document Supply Service, under shelf-number : Y 33163 / INIST-CNRS - Institut de l'Information Scientifique et TechniqueInstitut Gustave Roussy (IGR), 94 - Villejuif (France). Dept. de Chirurgie Generale CarcinologiqueFRFranc
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