Challenging challenges : a metaphysical redress of van den Haag's retributive axiom : Unequal justice over equal injustice

Includes abstract. Includes bibliographical references

Regret Aversion and False Reference Points in Residential Real Estate

This study empirically exams the combination of regret aversion and false reference points in a residential real estate context. Survey respondents were put in a hypothetical situation, where they had purchased an investment property several years ago. Hindsight knowledge about a foregone all time high was introduced. As hypothesized, respondents on average expressed higher regret if they had actively failed to sell at the all time high (commission scenario) than if they had simply been unaware of the potential gain (omission scenario). Women were found to be more susceptible to regret aversion and false reference points than men.

SModelS v1.0: a short user guide

SModelS is a tool for the automatic interpretation of simplified-model results from the LHC. Version 1.0 of the code is now publicly available. This document provides a quick user guide for installing and running SModelS v1.0.Comment: The code is available for download at http://smodels.hephy.at

Scrub Typhus in the Republic of Palau, Micronesia

In October 2001, an outbreak of febrile illness began in the southwest islands group of the Republic of Palau. Through October 2003, a total of 15 southwest islanders experienced fever >39.5°C and abdominal distress, both lasting >7days. Orientia tsutsugamushi, the agent of scrub typhus, was subsequently identified as the cause

Quality and speed in linear-scan register allocation

A linear-scan algorithm directs the global allocation of register candidates to registers based on a simple linear sweep over the program being compiled. This approach to register allocation makes sense for systems, such as those for dynamic compilation, where compilation speed is important. In contrast, most commercial and research optimizing compilers rely on a graph-coloring approach to global register allocation. In this paper, we compare the performance of a linear-scan method against a modern graph-coloring method. We implement both register allocators within the Machine SUIF extension of the Stanford SUIF compiler system. Experimental results show that linear scan is much faster than coloring on benchmarks with large numbers of register candidates. We also describe improvements to the linear-scan approach that do not change its linear character, but allow it to produce code of a quality near to that produced by graph coloring.Engineering and Applied Science

Quality and speed in linear-scan register allocation

A linear-scan algorithm directs the global allocation of register candidates to registers based on a simple linear sweep over the program being compiled. This approach to register allocation makes sense for systems, such as those for dynamic compilation, where compilation speed is important. In contrast, most commercial and research optimizing compilers rely on a graph-coloring approach to global register allocation. In this paper, we compare the performance of a linear-scan method against a modern graph-coloring method. We implement both register allocators within the Machine SUIF extension of the Stanford SUIF compiler system. Experimental results show that linear scan is much faster than coloring on benchmarks with large numbers of register candidates. We also describe improvements to the linear-scan approach that do not change its linear character, but allow it to produce code of a quality near to that produced by graph coloring.Engineering and Applied Science

Acute Administration of Non-Classical Estrogen Receptor Agonists Attenuates Ischemia-Induced Hippocampal Neuron Loss in Middle-Aged Female Rats

Pretreatment with 17beta-estradiol (E2) is profoundly neuroprotective in young animals subjected to focal and global ischemia. However, whether E2 retains its neuroprotective efficacy in aging animals, especially when administered after brain insult, is largely unknown.We examined the neuroprotective effects of E2 and two agonists that bind to non-classical estrogen receptors, G1 and STX, when administered after ischemia in middle-aged rats after prolonged ovarian hormone withdrawal. Eight weeks after ovariectomy, middle-aged female rats underwent 10 minutes of global ischemia by four vessel occlusion. Immediately after reperfusion, animals received a single infusion of either E2 (2.25 microg), G1 (50 microg) or STX (50 microg) into the lateral ventricle (ICV) or a single systemic injection of E2 (100 microg/kg). Surviving pyramidal neurons in the hippocampal CA1 were quantified 1 week later. E2 and both agonists that target non-classical estrogen receptors (G1 and STX) administered ICV at the time of reperfusion provided significant levels of neuroprotection, with 55-60% of CA1 neurons surviving vs 15% survival in controls. A single systemic injection of a pharmacological dose of E2 also rescued approximately 50% of CA1 pyramidal neurons destined to die. To determine if E2 and G1 have similar mechanisms of action in hippocampal neurons, we compared the ability of E2 and G1 to modify CA1 pyramidal neuron responses to excitatory inputs from the Schaffer collaterals recorded in hippocampal slices derived from female rats not subjected to global ischemia. E2 and G1 (10 nM) significantly potentiated pyramidal neuron responses to excitatory inputs when applied to hippocampal slices.These findings suggest (1) that middle-aged female rats retain their responsiveness to E2 even after a long period of hormone withdrawal, (2) that non-classical estrogen receptors may mediate the neuroprotective actions of E2 when given after ischemia, and (3) that the neuroprotective efficacy of estrogens may be related to their modulation of synaptic activity in hippocampal slices