Meta-analysis of the association between significant factors and the risk of DSS.

<p>Pooled ORs with corresponding 95% CIs of the published results were calculated where more than one study had investigated the marker.</p>*<p>Factor was presented as both dichotomous (frequency of higher values) and continuous (higher value) variables.</p>#<p>Factor was presented as a dichotomous (frequency of higher values) variable.</p>†<p>Factor was presented as a continuous variable.</p>a<p>adjusted odds ratio calculated after the addition of potential missing studies using the trim and fill method of Duvall and Tweedie.</p><p>Hemoconcentration was defined as an increase of hematocrit and presented as both dichotomous (frequency of higher values) and continuous (higher value) variables.</p><p>Neurological signs (any signs) were defined as patients had any signs of convulsion, decreased consciousness, drowsiness, and lethargy.</p><p>A particular dengue serotype infection was defined as a dichotomous variable versus infection with another DENV serotype (e.g., DENV-2 vs. non-DENV-2). Only studies investigated all four strains were included for the analysis.</p

Meta-regression analysis between the proportion of DSS among DHF/DSS cases and year of recruitment.

<p>All studies (A). Sub-regression analysis of all studies except three studies in South America (B), 49 studies in Southeast Asia (C), 16 studies in South Asia (D), seven studies in Caribbean countries (E), and 23 studies in Thailand (F). The logit event rate was calculated as follow: logit event rate = ln[event rate/(1 − event rate)]. The Y-axis on the right shows the proportion of DSS patients amongst DHF/DSS patients. Each circle represents a data set in the meta-analysis, and the size of the circle is proportional to study weighting.</p

Association between DSS and Hct level

<p>(A) or platelet count (B). Each symbol represents each category of Hct or platelet in each included study. Straight lines are the fitted first order polynomial models.</p

Meta-analysis of DENV-2 serotype including subgroup analysis in each country (A) and all countries beside Thailand (B).

<p>(A) Meta-analysis forest plot showing the pooled odd ratio of individual countries (orange symbol) and overall countries (red symbol) for association of DSS with 95% confidence intervals using mixed effect models. (B) The pooled odds ratio in subgroup analysis of all countries excluding Thailand indicated that DENV-2 was not significantly associated with DSS in these areas. The size of the symbol is proportional to study.</p

Flow diagram of the search and review process.

<p>Flow diagram of the search and review process.</p

Meta-regression analysis between children's age and DSS association over year of recruitment in South East Asia.

<p>(A) Difference in mean age between DSS and DHF groups; (B) Average age of DSS children over year of recruitment in South East Asia; (C) Average age of DHF children over year of recruitment in South East Asia. Each circle represents a data set in the meta-analysis, and the size of the circle is proportional to study weighting.</p

The duration of febrile episodes in enteric fever patients infected with <i>S.</i> Typhi organisms with a range of MICs to ofloxacin.

<p>Kaplan Meir curve showing the proportion of patients remaining febrile (>38°C) after the start of treatment with ofloxacin. Data is composed from fever clearance times of 540 children and adults with uncomplicated enteric fever recruited to seven randomised clinical trial and treated with oral ofloxacin. The curves are divided according to the ofloxacin MIC of the infecting isolates and are highlighted on the diagram.</p

Summary of TLR4 polymorphisms associated with infectious diseases.

<p>Summary of TLR4 polymorphisms associated with infectious diseases.</p