Results of MODS for 137 patients presenting with suspected TBM by final diagnosis.

<p>Results of MODS for 137 patients presenting with suspected TBM by final diagnosis.</p

Sensitivity of all techniques analysed by sample (n = 63), patient (n = 57) and HIV status. Specificity of all techniques in all cases was 100%.

<p>Sensitivity of all techniques analysed by sample (n = 63), patient (n = 57) and HIV status. Specificity of all techniques in all cases was 100%.</p

Cumulative percentage of positive cultures by day for MODS, MGIT and LJ culture.

<p>Cumulative percentage of positive cultures by day for MODS, MGIT and LJ culture.</p

<i>Cryptococcus neoformans</i> in MODS plate at ×400 magnification with inverted microscope.

<p><i>Cryptococcus neoformans</i> in MODS plate at ×400 magnification with inverted microscope.</p

Flowchart of patients presenting to Hospital for Tropical Diseases with suspected TBM during the study showing results for standard microbiological investigations (MGIT/LJ/ZN smear) and MODS on CSF samples.

<p>Flowchart of patients presenting to Hospital for Tropical Diseases with suspected TBM during the study showing results for standard microbiological investigations (MGIT/LJ/ZN smear) and MODS on CSF samples.</p

<i>M. tuberculosis</i> characteristic cording in MODS plate at ×400 magnification with inverted microscope.

<p><i>M. tuberculosis</i> characteristic cording in MODS plate at ×400 magnification with inverted microscope.</p

Features of 80 newly presenting patients with a final diagnosis other than TBM.

<p>HSV = herpes simplex virus, CXR = Chest X-ray, CT = computerised tomography, Cr Ag = cryptococcus neoformans antigen, (+) = positive, Neg = negative.</p

Features of 57 newly presenting patients with a final diagnosis of TBM.

<p>CXR = chest X-ray, CT = computerised tomography <u>of the</u> brain, TBM = tuberculous meningitis, + = positive, neg = negative, AFB = Acid fast bacilli, PTB = pulmonary tuberculosis.</p

Summary of 61 follow-up samples from 27 HIV-positive patients with HIV associated TBM on >7 days TB therapy*.

*<p>TB therapy = rifampicin, isoniazid, pyrazinamide, ethambutol for 3 months, followed by rifampicin and isoniazid for 6 months. All patients also received adjunctive dexamethsone therapy.</p

rs17525495 is associated with susceptibility to bacterial meningitis.

<p>^<i>a</i>frequency</p><p>^<i>b</i>cytosine</p><p>^<i>c</i>thymine</p><p>^<i>d</i>additive model</p><p>^<i>e</i>odds ratio (95% confidence interval)</p><p>^<i>f</i>general model; a genotypic model where one genotype group (e.g. CC group) is baseline</p><p>^<i>g</i>estimates of odds for general model, comparing baseline (CC) to CT</p><p>^<i>h</i>estimates of odds for general model comparing baseline (CC) to TT</p><p>^<i>i</i>recessive model</p><p>^<i>j</i>Hardy Weinberg Equilibrium</p><p>^<i>k</i>definite. NB: data for dominant and heterozygote advantage model were not significant and are not shown here.</p><p>rs17525495 is associated with susceptibility to bacterial meningitis.</p