171 research outputs found
Increased Incidence of Urethane Induced Lung Adenomata by Autosensitized Lymphocytes
The present work investigates the influence of autosensitized lymphocytes on the carcinogenic response of the host. Urethane treated SWR mice received 6 fortnightly injections of lymphocytes sensitized in vitro against syngeneic fibroblasts. An increased incidence of lung adenomata was found in these mice compared with controls injected with unsensitized lymphoid cells or with lymphoid cells sensitized against unrelated transplantation antigens. Autosensitized lymphocytes also modified the response of host lymphoid cells to concanavalin A or to stimulation in a mixed lymphocyte culture assay. These results indicate that autoimmune lymphocytes may increase susceptibility of a host to the induction of tumours
Caryocar brasiliense camb protects against genomic and oxidative damage in urethane-induced lung carcinogenesis
Increased reactivity of responding cells in the mixed lymphocyte reaction by a thymic humoral factor.
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