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    erythema multiforme like rash in a patient sensitive to ofloxacin

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    and increase matrix metalloproteinases-1 of dermal 10. Farrell AM. Acquired perforating dermatosis in renal and broblasts in three-dimensional cultures. J Dermatol Sci diabetic patients. Lancet 1997; 349: 895–896. 2000; 24: 99–104. 11. Golub LM, Ramamurthy NS, McNamara TF, Greenwald 9. Ryan ME, Usman A, Ramamurthy NS, Golub LM, RA, Rifkin BR. Tetracyclines inhibit connective tissue Greenwald RA. Excessive matrix metalloproteinase activbreakdown: new therapeutic implications for an old family ity in diabetes: inhibition by tetracycline analogues with of drugs. Crit Rev Oral Biol Med 1991; 2: 297–321. zinc reactivity. Curr Med Chem 2001; 8: 305–316
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