Semaphorin 3A Contributes to Distal Pulmonary Epithelial Cell Differentiation and Lung Morphogenesis

altered distal lung structure.) littermate controls. mice that survived the immediate perinatal period. Furthermore, Sema3A deletion was linked with enhanced postnatal alveolar septal cell death.These data suggest that Sema3A modulates distal pulmonary epithelial cell development and alveolar septation. Defining how Sema3A influences structural plasticity of the developing lung is a critical first step for determining if this pathway can be exploited to develop innovative strategies for repair after acute or chronic lung injury

Probing Ganymede's atmosphere with HST Lyα\alpha images in transit of Jupiter

We report results from far-ultraviolet observations by the Hubble Space Telescope of Jupiter's largest moon Ganymede transiting across the planet's dayside hemisphere. {Within} a targeted campaign on 9 September 2021 two exposures were taken during one transit passage to probe for attenuation of Jupiter's hydrogen Lyman-$\alpha$ dayglow above the moon limb. The background dayglow is slightly attenuated over an extended region around Ganymede, with stronger attenuation in the second exposure when Ganymede was near the planet's center. In the first exposure when the moon was closer to Jupiter's limb, the effects from the Ganymede corona are hardly detectable, likely because the Jovian Lyman-$\alpha$ dayglow is spectrally broader and less intense at this viewing geometry. The obtained vertical H column densities of around $(1-2)\times 10^{12}$~cm$^{-2}$ are consistent with previous results. Constraining angular variability around Ganymede's disk, we derive an upper limit on a local H$_2$O column density of $(2-3)\times 10^{16}$~cm$^{-2}$, such as could arise from outgassing plumes in regions near the observed moon limb

Constraints on Europa's water group torus from HST/COS observations

In-situ plasma measurements as well as remote mapping of energetic neutral atoms around Jupiter provide indirect evidence that an enhancement of neutral gas is present near the orbit of the moon Europa. Simulations suggest that such a neutral gas torus can be sustained by escape from Europa's atmosphere and consists primarily of molecular hydrogen, but the neutral gas torus has not yet been measured directly through emissions or in-situ. Here we present observations by the Cosmic Origins Spectrograph of the Hubble Space Telescope (HST/COS) from 2020 and 2021, which scanned the equatorial plane between 8 and 10 planetary radii west of Jupiter. No neutral gas emissions are detected. We derive upper limits on the emissions and compare these to modelled emissions from electron impact and resonant scattering using a Europa torus Monte Carlo model for the neutral gases. The comparison supports the previous findings that the torus is dilute and primarily consists of molecular hydrogen. A detection of sulfur ion emissions radially inward of the Europa orbit is consistent with emissions from the extended Io torus and with sulfur ion fractional abundances as previously detected

Non-perturbative effects and the refined topological string

The partition function of ABJM theory on the three-sphere has non-perturbative corrections due to membrane instantons in the M-theory dual. We show that the full series of membrane instanton corrections is completely determined by the refined topological string on the Calabi-Yau manifold known as local P1xP1, in the Nekrasov-Shatashvili limit. Our result can be interpreted as a first-principles derivation of the full series of non-perturbative effects for the closed topological string on this Calabi-Yau background. Based on this, we make a proposal for the non-perturbative free energy of topological strings on general, local Calabi-Yau manifolds.Comment: 38 pages, 5 figure

Final results from the Palo Verde Neutrino Oscillation Experiment

The analysis and results are presented from the complete data set recorded at Palo Verde between September 1998 and July 2000. In the experiment, the \nuebar interaction rate has been measured at a distance of 750 and 890 m from the reactors of the Palo Verde Nuclear Generating Station for a total of 350 days, including 108 days with one of the three reactors off for refueling. Backgrounds were determined by (a) the $swap$ technique based on the difference between signal and background under reversal of the positron and neutron parts of the correlated event and (b) making use of the conventional reactor-on and reactor-off cycles. There is no evidence for neutrino oscillation and the mode \nuebar\to\bar\nu_x was excluded at 90% CL for \dm>1.1\times10^{-3} eV$^2$ at full mixing, and \sinq>0.17 at large \dm.Comment: 11 pages, 8 figure

Mid-ultraviolet Hubble Observations of Europa and the Global Surface Distribution of SO₂

We present spatially resolved reflectance spectra of Europa’s surface in the wavelength range of 210–315 nm obtained by the Hubble Space Telescope Imaging Spectrograph in 2018 and 2019. These data provide the first high-quality, near-global spectral observations of Europa from 210 to 240 nm. They show that the reflectance of Europa’s leading, trailing, anti-Jovian, and sub-Jovian hemispheres is ∼5% near 210 nm, with varying spectral slopes across the mid-UV. This low albedo, even on the more “pristine” leading hemisphere, indicates a lack of the signature far-UV spectral edge characteristic of water ice. We detected and mapped a strong absorption feature at 280 nm that is consistent with an S–O bond that has previously been attributed to SO2 on the surface, hypothesized to be formed through radiolytic processing of Iogenic sulfur ions that have been preferentially emplaced on Europa’s trailing hemisphere by Jupiter’s magnetic field. Our models show that small inclusions of SO2 (0.1%) within the water ice are sufficient to produce the 280 nm feature without producing a feature at 4.07 μm, which has not been observed in ground-based spectral observations of Europa. This data set is the first to produce a spatially resolved, near-global map of the assumed SO2 feature, which is primarily concentrated near the apex of the trailing hemisphere and correlated with large-scale darker regions in both the visible and the ultraviolet. This distribution is consistent with “cold” exogenic sulfur ion bombardment on Europa